cytoxan - PMC

David J Tunnicliffe, Suetonia C Palmer, Lorna Henderson, Philip Masson, Jonathan C Craig, Allison Tong, Davinder Singh‐Grewal, Robert S Flanc, Matthew A Roberts, Angela C Webster, Giovanni FM Strippoli, Cochrane Kidney and Transplant Group

Cochrane Database Syst Rev. 2018; 2018(6): CD002922. Published online 2018 Jun 29. doi: 10.1002/14651858.CD002922.pub4

PMCID:: PMC6513226

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Keratinocyte Growth Factor Reduces Injury and Leads to Early Recovery from Cyclophosphamide Bladder Injury

Sridhar T. Narla, Daniel S. Bushnell, Caitlin M. Schaefer, Mehdi Nouraie, Carlton M. Bates

Am J Pathol. 2020 Jan; 190(1): 108–124. doi: 10.1016/j.ajpath.2019.09.015

PMCID:: PMC6943803

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Minocycline, a putative neuroprotectant, co-administered with doxorubicin-cyclophosphamide chemotherapy in a xenograft model of triple-negative breast cancer

Lauren E. Himmel, Maryam B. Lustberg, A. Courtney DeVries, Ming Poi, Ching-Shih Chen, Samuel K. Kulp

Exp Toxicol Pathol. Author manuscript; available in PMC 2017 Oct 1.

Published in final edited form as: Exp Toxicol Pathol. 2016 Oct; 68(9): 505–515. Published online 2016 Aug 21. doi: 10.1016/j.etp.2016.08.001

PMCID:: PMC5203928

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Cyclophosphamide versus methylprednisolone for treating neuropsychiatric involvement in systemic lupus erythematosus

Virginia Fernandes Moça Trevisani, Aldemar A Castro, João Ferreira Neves Neto, Álvaro N Atallah, Cochrane Musculoskeletal Group

Cochrane Database Syst Rev. 2013 Feb; 2013(2): CD002265. Published online 2013 Feb 28. doi: 10.1002/14651858.CD002265.pub3

PMCID:: PMC6823222

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Kinase-independent inhibition of cyclophosphamide-induced pathways protects the ovarian reserve and prolongs fertility

Giovanna Bellusci, Luca Mattiello, Valentina Iannizzotto, Sarah Ciccone, Emiliano Maiani, Valentina Villani, Marc Diederich, Stefania Gonfloni

Cell Death Dis. 2019 Oct; 10(10): 726. Published online 2019 Sep 27. doi: 10.1038/s41419-019-1961-y

PMCID:: PMC6765024

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D-Tryptophan-6 analog of luteinizing hormone-releasing hormone as a protective agent against testicular damage caused by cyclophosphamide in baboons.

R W Lewis, K J Dowling, A V Schally

Proc Natl Acad Sci U S A. 1985 May; 82(9): 2975–2979. doi: 10.1073/pnas.82.9.2975

PMCID:: PMC397689

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Early viral reactivation despite excellent immune reconstitution following haploidentical Bone marrow transplant with post-transplant cytoxan for sickle cell disease

Dilan A. Patel, Nathalie Dhedin, Heidi Chen, Leena Karnik, Katie Gatwood, Katie Culos, Sanjay Mohan, Brian G. Engelhardt, Carrie Kitko, Jim Connelly, Gowri Satyanarayana, Madan Jagasia, Josu De La Fuente, Adetola Kassim

Transpl Infect Dis. Author manuscript; available in PMC 2023 Jun 12.

Published in final edited form as: Transpl Infect Dis. 2020 Feb; 22(1): e13222. Published online 2019 Dec 19. doi: 10.1111/tid.13222

PMCID:: PMC10260348

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Role of ERK signaling in bladder urothelium in response to cyclophosphamide injury

Sridhar Tatarao Narla, Joanne Lindsey Duara, Daniel Scott Bushnell, Mehdi Nouraie, Jacqueline Holden, Katherine Pfister, Peter C. Lucas, Sunder Sims‐Lucas, Carlton Matthew Bates

Physiol Rep. 2022 Jul; 10(14): 10.14814/phy2.15378. Published online 2022 Jul 19. doi: 10.14814/phy2.15378

PMCID:: PMC9296905

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Mechanisms of Graft-versus-Host Disease Prevention by Post-transplantation Cyclophosphamide: An Evolving Understanding

Natalia S. Nunes, Christopher G. Kanakry

Front Immunol. 2019; 10: 2668. Published online 2019 Nov 29. doi: 10.3389/fimmu.2019.02668

PMCID:: PMC6895959

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The critical early proinflammatory events associated with idiopathic pneumonia syndrome in irradiated murine allogeneic recipients are due to donor T cell infusion and potentiated by cyclophosphamide.

A Panoskaltsis-Mortari, P A Taylor, T M Yaeger, O D Wangensteen, P B Bitterman, D H Ingbar, D A Vallera, B R Blazar

J Clin Invest. 1997 Sep 1; 100(5): 1015–1027. doi: 10.1172/JCI119612

PMCID:: PMC508276

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The Role of Antioxidants in Ameliorating Cyclophosphamide-Induced Cardiotoxicity

Muluken Altaye Ayza, Kaleab Alemayehu Zewdie, Bekalu Amare Tesfaye, Dawit Zewdu Wondafrash, Abera Hadgu Berhe

Oxid Med Cell Longev. 2020; 2020: 4965171. Published online 2020 May 10. doi: 10.1155/2020/4965171

PMCID:: PMC7238386

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CNS penetration of cyclophosphamide and metabolites in mice bearing Group 3 medulloblastoma and non-tumor bearing mice

Olivia Campagne, Abigail Davis, Bo Zhong, Sreenath Nair, Victoria Haberman, Yogesh T. Patel, Laura Janke, Martine F. Roussel, Clinton F. Stewart

J Pharm Pharm Sci. Author manuscript; available in PMC 2020 Aug 7.

Published in final edited form as: J Pharm Pharm Sci. 2019; 22(1): 612–629. doi: 10.18433/jpps30608

PMCID:: PMC7413074

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Cyclophosphamide alters the tumor cell secretome to potentiate the anti-myeloma activity of daratumumab through augmentation of macrophage-mediated antibody dependent cellular phagocytosis

Serika D Naicker, Claire L Feerick, Kevin Lynch, Dawn Swan, Cian McEllistrim, Robert Henderson, Niamh A Leonard, Oliver Treacy, Alessandro Natoni, Athina Rigalou, Joana Cabral, Christopher Chiu, Kate Sasser, Thomas Ritter, Michael O’Dwyer, Aideen E Ryan

Oncoimmunology. 2021; 10(1): 1859263. Published online 2021 Jan 25. doi: 10.1080/2162402X.2020.1859263

PMCID:: PMC7849715

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L-carnitine Modulates Cognitive Impairment Induced by Doxorubicin and Cyclophosphamide in Rats; Insights to Oxidative Stress, Inflammation, Synaptic Plasticity, Liver/brain, and Kidney/brain Axes

Olivia Fayez Morid, Esther T. Menze, Mariane G. Tadros, Mina Y. George

J Neuroimmune Pharmacol. 2023; 18(3): 310–326. Published online 2023 May 4. doi: 10.1007/s11481-023-10062-1

PMCID:: PMC10577097

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Cyclophosphamide Enhances Human Tumor Growth in Nude Rat Xenografted Tumor Models

Yingjen Jeffrey Wu, Leslie L. Muldoon, Dana Thomas Dickey, Seth J. Lewin, Csanad G. Varallyay, Edward A. Neuwelt

Neoplasia. 2009 Feb; 11(2): 187–195. doi: 10.1593/neo.81352

PMCID:: PMC2631143

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The effect of cyclophosphamide on an ocular immune response. I. Primary response.

J M Hall, S Ohno, J F Pribnow

Clin Exp Immunol. 1977 Nov; 30(2): 309–316.

PMCID:: PMC1541121

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Pharmacokinetics of Cyclophosphamide after Oral and Intravenous Administration to Dogs with Lymphoma

E. Warry, R. J. Hansen, D. L. Gustafson, S. E. Lana

J Vet Intern Med. Author manuscript; available in PMC 2015 Feb 17.

Published in final edited form as: J Vet Intern Med. 2011 Jul-Aug; 25(4): 903–908. Published online 2011 May 12. doi: 10.1111/j.1939-1676.2011.0730.x

PMCID:: PMC4331015

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Figure 2

Incidence proportion of anemia by grade associated with selected regimens during the course of chemotherapy.
Abbreviations: AC, doxorubicin (Adriamycin) and cyclophosphamide (Cytoxan); TAC, docetaxel (Taxotere), doxorubicin (Adriamycin), and cyclophosphamide (Cytoxan); AC → T, doxorubicin (Adriamycin) and cyclophosphamide (Cytoxan) followed by paclitaxel (Taxol) or docetaxel (Taxotere); TC, docetaxel (Taxotere) and cyclophosphamide (Cytoxan); TCH, Taxotere, Carboplatin, Herceptin; CAPOX, capecitabine and oxaliplatin; FOLFOX, Leucovorin calcium, 5-Fluorouracil and Oxaliplatin; CARBO + TAX, carboplatin and Paclitaxel (Taxol); CARBO + VP16, Carboplatin and Etoposide; Hb, hemoglobin.

Incidence of anemia in patients diagnosed with solid tumors receiving chemotherapy, 2010–2013

Clin Epidemiol. 2016;8:61-71.
FIGURE 5

Kaplan–Meier survival curves of drug response in Cluster 1 and Cluster 2. (A) Adriamycin treatment in Cluster 1, (B) Cytoxan treatment in Cluster 1, (C) Adriamycin treatment in Cluster 2, and (D) Cytoxan treatment in Cluster 2.

Multi-View Spectral Clustering Based on Multi-Smooth Representation Fusion for Cancer Subtype Prediction

Front Genet. 2021;12:718915.
Figures 3

DC-C patients have improved T cell proliferation after cyclophosphamide. Proliferative responses were measured by CFSE. The mean for each population is shown. OVCA=ovarian cancer patients off protocol, DC-C=dendritic cell vaccine recipients with Cytoxan, DC-NC-dendritic cell vaccine recipients without Cytoxan.

Immunologic consequences of chemotherapy for ovarian cancer: Impaired responses to the influenza vaccine

Vaccine. ;31(46):10.1016/j.vaccine.2013.09.001.
Figure 6:Cytoxan improves the antitumor activity of SIRPα-Fc-VV in immune-competent osteosarcoma model.

C57BL/6 mice were injected with 5×10⁵ F420 cells s.c. into the right flank. After 9 days mice (n=10 per group) were injected i.p. with 250mg/kg cytoxan. 48 hours later, tumors were injected i.t. with 1×10⁷ PFU of SIRPα-Fc-VV or YFP-VV. PBS-injected tumors served as controls (Co). Tumor size was monitored with caliper measurements. (A) Tumor volume (dotted lines: individual mice; solid line: median). (B) Kaplan-Meier survival curves. The Wilcoxon test with Holm method for adjustment of multiple comparisons was used to determine significance.

Engineering Oncolytic Vaccinia Virus to redirect Macrophages to Tumor Cells

Adv Cell Gene Ther. ;4(2):e99.