PMC

a, Body weight unchanged in 11- to 13-week-olds; P = 0.394 (WT n = 23 (11 male/12 female); HET n = 42 (25 male/17 female); KO n = 25 (14 male/11 female)). b, c, No difference in body weight grouped or divided by sex was observed among 11- to 13-week-old mice; (a) grouped body weight; P = 0.394; (b) female body weight; P = 0.6732; (c) male body weight; P = 0.240. d, Body weight is slightly decreased in Kctd13 mutants; P = 0.008 (WT n = 88 (40 male/48 female); HET n = 86 (28 male/58 female); KO n = 82 (36 male/46 female)). e–g, Brain weight not affected in 11- to 14-week-olds; (e) grouped brain weight, P = 0.112 (WT n = 23 (11 male/12 female); HET n = 42 (25 male/17 female); KO n = 25 (14 male/11 female)); (f) female brain weight, P = 0.328; (g) male brain weight; P = 0.322. h–j, No difference in the ratio of brain to body weight was observed among 11- to 14-week-old mice; (h) grouped ratio of brain to body weight; P = 0.2952; (i) female ratio of brain to body weight; P = 0.998620; (j) male ratio of brain to body weight; P = 0.128485. Same cohort and n values as in e–g above. Box (interquartile range), whiskers (5th–95th percentile confidence intervals), line (median) in box and whisker plots.

A, body weight of rats in the whole experimental period; B, increased body weight ratio of treatment period; C, increased body weight ratio of recovery period. The data are expressed as means ± SD (*P<0.05; **P<0.01).

The kidney to body weight ratio was measured as the average weight of both kidneys per 100 g body weight. (a) Kidney to body weight ratio for animals treated with increasing doses of CM. (b) Kidney to body weight ratio for animals pretreated with sildenafil citrate (6.0 mg/kg; single dose or q8 h).

(a) Body weight, (b) Heart weight, (c) Heart weight/ body weight ratio, (d) Lung weight and (e) Lung weight/ body weight ratio at 12 weeks of age in the WKY + normal-salt group (WKY+NS), WKY + high-salt group (WKY+HS), SHR + normal-salt group (SHR+NS) and SHR + high-salt group (SHR+HS). Data represent the means ± SEM (n = 7). **: p < 0.01, *: p < 0.05.