aclacinomycin - PMC

Maroof Hasan, Charles S. Fermaintt, Ningguo Gao, Tomomi Sakai, Takuya Miyazaki, Sixin Jiang, Quan-Zhen Li, John P. Atkinson, Herbert C. Morse, III, Mark A. Lehrman, Nan Yan

Immunity. Author manuscript; available in PMC 2016 Sep 15.

Published in final edited form as: Immunity. 2015 Sep 15; 43(3): 463–474. Published online 2015 Aug 25. doi: 10.1016/j.immuni.2015.07.022

PMCID:: PMC4575271

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Redox-Regulated Pathway of Tyrosine Phosphorylation Underlies NF-κB Induction by an Atypical Pathway Independent of the 26S Proteasome

Sarah Cullen, Subramaniam Ponnappan, Usha Ponnappan

Biomolecules. 2015 Mar; 5(1): 95–112. Published online 2015 Feb 9. doi: 10.3390/biom5010095

PMCID:: PMC4384113

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DNase-active TREX1 frame-shift mutants induce serologic autoimmunity in mice

Tomomi Sakai, Takuya Miyazaki, Dong-Mi Shin, Yong-Soo Kim, Chen-Feng Qi, Robert Fariss, Jeeva Munasinghe, Hongsheng Wang, Alexander L. Kovalchuk, Parul H. Kothari, Charles S. Fermaintt, John P. Atkinson, Fred W. Perrino, Nan Yan, Herbert C. Morse, III

J Autoimmun. Author manuscript; available in PMC 2017 Aug 16.

Published in final edited form as: J Autoimmun. 2017 Jul; 81: 13–23. Published online 2017 Mar 18. doi: 10.1016/j.jaut.2017.03.001

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Decitabine priming prior to low-dose chemotherapy improves patient outcomes in myelodysplastic syndromes-RAEB: a retrospective analysis vs. chemotherapy alone

Li Ye, Yanling Ren, Xinping Zhou, Chen Mei, Liya Ma, Xingnong Ye, Juying Wei, Weilai Xu, Haitao Meng, Wenbin Qian, Wenyuan Mai, Yinjun Lou, Gaixiang Xu, Jiejing Qian, Yejiang Lou, Yingwan Luo, Lili Xie, Peipei Lin, Chao Hu, Jie Jin, Hongyan Tong

J Cancer Res Clin Oncol. 2017; 143(5): 873–882. Published online 2017 Jan 20. doi: 10.1007/s00432-016-2331-0

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High-density lipoprotein as a potential carrier for delivery of a lipophilic antitumoral drug into hepatoma cells

Bin Lou, Xue-Ling Liao, Man-Ping Wu, Pei-Fang Cheng, Chun-Yan Yin, Zheng Fei

World J Gastroenterol. 2005 Feb 21; 11(7): 954–959. Published online 2005 Feb 21. doi: 10.3748/wjg.v11.i7.954

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In vitro interaction of lithotripter shock waves and cytotoxic drugs.

S. Gambihler, M. Delius

Br J Cancer. 1992 Jul; 66(1): 69–73. doi: 10.1038/bjc.1992.218

PMCID:: PMC1977919

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CATALYTIC ACTIVITY OF THE PROTEASOME FINE-TUNES BRG1-MEDIATED CHROMATIN REMODELING TO REGULATE THE EXPRESSION OF INFLAMMATORY GENES

Sarah J. Cullen, Subramaniam Ponnappan, Usha Ponnappan

Mol Immunol. Author manuscript; available in PMC 2010 Dec 1.

Published in final edited form as: Mol Immunol. 2009 Dec; 47(2-3): 600–605. Published online 2009 Oct 1. doi: 10.1016/j.molimm.2009.09.008

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Effect of Adriamycin on DNA, RNA and Protein Biosyntheses in Mouse Tissues, in Connection with Its Cardiotoxicity

Yasuyuki Sazuka, Hisayuki Tanizawa, Yoshio Takino

Jpn J Cancer Res. 1989 Oct; 80(10): 1000–1005. doi: 10.1111/j.1349-7006.1989.tb01640.x

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HAA方案治疗复发难治性急性髓系白血病64例疗效观察

范翠华, 俞文娟, 麦文渊, 孟海涛, 钱文斌, 佟红艳, 黄健, 毛丽萍, 索珊珊, 金洁

Zhonghua Xue Ye Xue Za Zhi. 2016 Feb; 37(2): 100–104. Chinese. doi: 10.3760/cma.j.issn.0253-2727.2016.02.003

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A phase II study of chidamide, cytarabine, aclarubicin, granulocyte colony-stimulating factor, and donor lymphocyte infusion for relapsed acute myeloid leukemia and myelodysplastic syndrome after allogeneic hematopoietic stem cell transplantation

Yan Wei, Lijun Wang, Chengying Zhu, Honghua Li, Jian Bo, Ran Zhang, Ning Lu, Yongli Wu, Xiaoning Gao, Liping Dou, Daihong Liu, Chunji Gao

Med Oncol. 2023; 40(2): 77. Published online 2023 Jan 10. doi: 10.1007/s12032-022-01911-9

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Divergent evolution of an atypical S-adenosyl-l-methionine–dependent monooxygenase involved in anthracycline biosynthesis

Thadée Grocholski, Pedro Dinis, Laila Niiranen, Jarmo Niemi, Mikko Metsä-Ketelä

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Comparative genome features and secondary metabolite biosynthetic potential of Kutzneria chonburiensis and other species of the genus Kutzneria

Manee Chanama, Pinidphon Prombutara, Suchart Chanama

Sci Rep. 2023; 13: 8794. Published online 2023 May 31. doi: 10.1038/s41598-023-36039-x

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Expression, Purification, and Characterization of AknX Anthrone Oxygenase, Which Is Involved in Aklavinone Biosynthesis in Streptomyces galilaeus

Jin-young Chung, Isao Fujii, Shigeharu Harada, Ushio Sankawa, Yutaka Ebizuka

J Bacteriol. 2002 Nov; 184(22): 6115–6122. doi: 10.1128/JB.184.22.6115-6122.2002

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Characterization of rhodosaminyl-transfer by the AknS/AknT glycosylation complex and its use in reconstituting the biosynthetic pathway of Aclacinomycin A

Catherine Leimkuhler, Micha Fridman, Tania Lupoli, Suzanne Walker, Christopher T. Walsh, Daniel Kahne

J Am Chem Soc. Author manuscript; available in PMC 2008 Nov 6.

Published in final edited form as: J Am Chem Soc. 2007 Aug 29; 129(34): 10546–10550. Published online 2007 Aug 8. doi: 10.1021/ja072909o

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Effect of anticancer agents neothramycin, aclacinomycin, FK-565 and FK-156 on the release of interleukin-2 and interleukin-1 in vitro

Khalid Ahmed, John L. Turk

Cancer Immunol Immunother. 1989 Feb; 28(2): 87–92. doi: 10.1007/BF00199107

PMCID:: PMC11038598

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Figure 2

Biosynthetic Pathway of Aclacinomycin A. a) Proposed biosynthetic patway: AknS/AknT transfers TDP-L-rhodosamine to aklavinone 4 to give rhodosaminyl-aklavinone 5. AknK then transfers TDP-2-deoxy-L-fucose followed by TDP-L-rhodinose which is then oxidized to yield Aclacinomycin A. b) HPLC analysis of AknS/T transfer of TDP- L-rhodosamine to aklavinone 4 to give rhodosaminylaklavinone 5.

Characterization of rhodosaminyl-transfer by the AknS/AknT glycosylation complex and its use in reconstituting the biosynthetic pathway of Aclacinomycin A

J Am Chem Soc. ;129(34):10546-10550.
Figure 1

Scanning electron micrograph of RGD-ACM liposomes.
Notes: Magnification 50,000×. (A) RGD-ACM liposomes and (B) non-modified ACM liposomes.
Abbreviations: ACM, aclacinomycin A; RGD, arginine-glycine-aspartic acid.

RGD-modified liposomes enhance efficiency of aclacinomycin A delivery: evaluation of their effect in lung cancer

Drug Des Devel Ther. 2015;9:4613-4620.
Figure 2

In vitro release of ACM-loaded liposomes in phosphate-buffered saline (pH 7.4, n=3).
Notes: Gray line indicates free ACM; light blue line indicates ACM liposomes, red line indicates RGD-ACM liposomes.
Abbreviations: ACM, aclacinomycin A; RGD, arginine-glycine-aspartic acid.

RGD-modified liposomes enhance efficiency of aclacinomycin A delivery: evaluation of their effect in lung cancer

Drug Des Devel Ther. 2015;9:4613-4620.
Figure 4

Mean plasma ACM concentration in rats after intravenous administration (8 mg/kg) of the two formulations (n=6). The blue line indicates RGD-ACM liposomes and the red line indicates ACM liposomes.
Abbreviations: ACM, aclacinomycin A; RGD, arginine-glycine-aspartic acid.

RGD-modified liposomes enhance efficiency of aclacinomycin A delivery: evaluation of their effect in lung cancer

Drug Des Devel Ther. 2015;9:4613-4620.