Sexual hormones and aging - PMC

Rocco S. Calabrò, Alberto Cacciola, Daniele Bruschetta, Demetrio Milardi, Fabrizio Quattrini, Francesca Sciarrone, Gianluca la Rosa, Placido Bramanti, Giuseppe Anastasi

Brain Behav. 2019 Dec; 9(12): e01389. Published online 2019 Sep 30. doi: 10.1002/brb3.1389

PMCID:: PMC6908863

Abstract Article PDF–844K

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Standards of Care for the Health of Transgender and Gender Diverse People, Version 8

E. Coleman, A. E. Radix, W. P. Bouman, G. R. Brown, A. L. C. de Vries, M. B. Deutsch, R. Ettner, L. Fraser, M. Goodman, J. Green, A. B. Hancock, T. W. Johnson, D. H. Karasic, G. A. Knudson, S. F. Leibowitz, H. F. L. Meyer-Bahlburg, S. J. Monstrey, J. Motmans, L. Nahata, T. O. Nieder, S. L. Reisner, C. Richards, L. S. Schechter, V. Tangpricha, A. C. Tishelman, M. A. A. Van Trotsenburg, S. Winter, K. Ducheny, N. J. Adams, T. M. Adrián, L. R. Allen, D. Azul, H. Bagga, K. Başar, D. S. Bathory, J. J. Belinky, D. R. Berg, J. U. Berli, R. O. Bluebond-Langner, M.-B. Bouman, M. L. Bowers, P. J. Brassard, J. Byrne, L. Capitán, C. J. Cargill, J. M. Carswell, S. C. Chang, G. Chelvakumar, T. Corneil, K. B. Dalke, G. De Cuypere, E. de Vries, M. Den Heijer, A. H. Devor, C. Dhejne, A. D’Marco, E. K. Edmiston, L. Edwards-Leeper, R. Ehrbar, D. Ehrensaft, J. Eisfeld, E. Elaut, L. Erickson-Schroth, J. L. Feldman, A. D. Fisher, M. M. Garcia, L. Gijs, S. E. Green, B. P. Hall, T. L. D. Hardy, M. S. Irwig, L. A. Jacobs, A. C. Janssen, K. Johnson, D. T. Klink, B. P. C. Kreukels, L. E. Kuper, E. J. Kvach, M. A. Malouf, R. Massey, T. Mazur, C. McLachlan, S. D. Morrison, S. W. Mosser, P. M. Neira, U. Nygren, J. M. Oates, J. Obedin-Maliver, G. Pagkalos, J. Patton, N. Phanuphak, K. Rachlin, T. Reed, G. N. Rider, J. Ristori, S. Robbins-Cherry, S. A. Roberts, K. A. Rodriguez-Wallberg, S. M. Rosenthal, K. Sabir, J. D. Safer, A. I. Scheim, L. J. Seal, T. J. Sehoole, K. Spencer, C. St. Amand, T. D. Steensma, J. F. Strang, G. B. Taylor, K. Tilleman, G. G. T’Sjoen, L. N. Vala, N. M. Van Mello, J. F. Veale, J. A. Vencill, B. Vincent, L. M. Wesp, M. A. West, J. Arcelus

Int J Transgend Health. 2022; 23(Suppl 1): S1–S259. Published online 2022 Sep 6. doi: 10.1080/26895269.2022.2100644

Correction in:: Int J Transgend Health. 2022; 23(Suppl 1): S259–S261.

PMCID:: PMC9553112

Abstract Article PDF–12M

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Aromatase Inhibition Eliminates Sexual Receptivity Without Enhancing Weight Gain in Ovariectomized Marmoset Monkeys

Marissa Kraynak, Molly M Willging, Alex L Kuehlmann, Amita A Kapoor, Matthew T Flowers, Ricki J Colman, Jon E Levine, David H Abbott

J Endocr Soc. 2022 Jun 1; 6(6): bvac063. Published online 2022 Apr 22. doi: 10.1210/jendso/bvac063

PMCID:: PMC9113444

Abstract Article PDF–4.3M

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Psychobiological Factors of Sexual Functioning in Aging Women – Findings From the Women 40+ Healthy Aging Study

Laura Mernone, Serena Fiacco, Ulrike Ehlert

Front Psychol. 2019; 10: 546. Published online 2019 Mar 13. doi: 10.3389/fpsyg.2019.00546

PMCID:: PMC6424880

Abstract Article PDF–1.0M

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The Italian Society of Andrology and Sexual Medicine (SIAMS), along with ten other Italian Scientific Societies, guidelines on the diagnosis and management of erectile dysfunction

G. Corona, D. Cucinotta, G. Di Lorenzo, A. Ferlin, V. A. Giagulli, L. Gnessi, A. M. Isidori, M. I. Maiorino, P. Miserendino, A. Murrone, R. Pivonello, V. Rochira, G. M. Sangiorgi, G. Stagno, C. Foresta, A. Lenzi, M. Maggi, E. A. Jannini

J Endocrinol Invest. 2023; 46(6): 1241–1274. Published online 2023 Jan 25. doi: 10.1007/s40618-023-02015-5

PMCID:: PMC9876440

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International Society for the Study of Women's Sexual Health Clinical Practice Guideline for the Use of Systemic Testosterone for Hypoactive Sexual Desire Disorder in Women

Sharon J. Parish, James A. Simon, Susan R. Davis, Annamaria Giraldi, Irwin Goldstein, Sue W. Goldstein, Noel N. Kim, Sheryl A. Kingsberg, Abraham Morgentaler, Rossella E. Nappi, Kwangsung Park, Cynthia A. Stuenkel, Abdulmaged M. Traish, Linda Vignozzi

J Womens Health (Larchmt) April 2021; 30(4): 474–491. Published online 2021 Apr 19. doi: 10.1089/jwh.2021.29037

PMCID:: PMC8064950

Abstract Article PDF–599K

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Effects of velvet antler polypeptide on sexual behavior and testosterone synthesis in aging male mice

Zhi-Jun Zang, Hong-Feng Tang, Ying Tuo, Wei-Jie Xing, Su-Yun Ji, Yong Gao, Chun-Hua Deng

Asian J Androl. 2016 Jul-Aug; 18(4): 613–619. Published online 2015 Nov 24. doi: 10.4103/1008-682X.166435

PMCID:: PMC4955189

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Sexual Disorders and Quality of Life in Parkinson's Disease

Claudia Marques Santa Rosa Malcher, Kleber Roberto da Silva Gonçalves Oliveira, Milena Coelho Fernandes Caldato, Bruno Lopes dos Santos Lobato, Janari da Silva Pedroso, Marco de Tubino Scanavino

Sex Med. 2021 Feb; 9(1): 100280. Published online 2021 Jan 8. doi: 10.1016/j.esxm.2020.10.008

PMCID:: PMC7930860

Abstract Article PDF–466K

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Physical Intimacy Is an Important Part of Sexual Activities: Korean Older Adults Study

Ho Seok Chung, Gyeong Hun Kim, Min-Ho Shin, Kwangsung Park

Sex Med. 2020 Dec; 8(4): 643–649. Published online 2020 Aug 6. doi: 10.1016/j.esxm.2020.06.011

PMCID:: PMC7691871

Abstract Article PDF–278K

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Sexual Dysfunctions Among People Living With HIV With Long-Term Treatment With Antiretroviral Therapy

Marco De Tubino Scanavino, Emi Mori, Vera Vichr Nisida, Vivian I. Avelino-Silva, Maria Luiza Sant'ana do Amaral, Bruna Messina, Aluisio Cotrim Segurado

Sex Med. 2022 Oct; 10(5): 100542. Published online 2022 Jul 21. doi: 10.1016/j.esxm.2022.100542

PMCID:: PMC9537266

Abstract Article PDF–328K

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Changes in Androgen Receptor, Estrogen Receptor alpha, and Sexual Behavior with Aging and Testosterone in Male Rats

Di Wu, Andrea C. Gore

Horm Behav. Author manuscript; available in PMC 2011 Jul 1.

Published in final edited form as: Horm Behav. 2010 Jul; 58(2): 306–316. Published online 2010 Mar 16. doi: 10.1016/j.yhbeh.2010.03.001

PMCID:: PMC2879440

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The impact of the COVID-19 pandemic-related quarantine on female sexual behavior: a cross-sectional study in China

Guangyong Li, Puguang Yu, Fen Zhang, Yanlong Xu, Gaiyan Zhou, Xuekang Zhan, Yu Gao, Xiaoli Du, Hetao Liu, Rui He

Sci Rep. 2022; 12: 19421. Published online 2022 Nov 12. doi: 10.1038/s41598-022-23974-4

PMCID:: PMC9653494

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Zebrafish sexual behavior: role of sex steroid hormones and prostaglandins

Ajay Pradhan, Per-Erik Olsson

Behav Brain Funct. 2015; 11: 23. Published online 2015 Aug 13. doi: 10.1186/s12993-015-0068-6

PMCID:: PMC4575480

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Sexual hormones regulate the redox status and mitochondrial function in the brain. Pathological implications

Margalida Torrens-Mas, Daniel-Gabriel Pons, Jorge Sastre-Serra, Jordi Oliver, Pilar Roca

Redox Biol. 2020 Apr; 31: 101505. Published online 2020 Mar 14. doi: 10.1016/j.redox.2020.101505

PMCID:: PMC7212485

Abstract Article PDF–902K

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Hormonal Contraceptives, Female Sexual Dysfunction, and Managing Strategies: A Review

Nerea M. Casado-Espada, Rubén de Alarcón, Javier I. de la Iglesia-Larrad, Berta Bote-Bonaechea, Ángel L. Montejo

J Clin Med. 2019 Jun; 8(6): 908. Published online 2019 Jun 25. doi: 10.3390/jcm8060908

PMCID:: PMC6617135

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Hormonal Regulation of Oligodendrogenesis I: Effects across the Lifespan

Kimberly L. P. Long, Jocelyn M. Breton, Matthew K. Barraza, Olga S. Perloff, Daniela Kaufer

Biomolecules. 2021 Feb; 11(2): 283. Published online 2021 Feb 14. doi: 10.3390/biom11020283

PMCID:: PMC7918364

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Cognitive Impairment, Sexual Activity and Physical Tenderness in Community-Dwelling Older Adults: A Cross-Sectional Exploration

Rosanne Freak-Poli, Silvan Licher, Joanne Ryan, M. Arfan Ikram, Henning Tiemeier

Gerontology. 2018 Oct; 64(6): 589–602. Published online 2018 Aug 23. doi: 10.1159/000490560

PMCID:: PMC6262681

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Select item 1025269720.

Sex and Brain: The Role of Sex Chromosomes and Hormones in Brain Development and Parkinson’s Disease

Francesca Terrin, Annachiara Tesoriere, Nicoletta Plotegher, Luisa Dalla Valle

Cells. 2023 Jun; 12(11): 1486. Published online 2023 May 27. doi: 10.3390/cells12111486

PMCID:: PMC10252697

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Figure 2

Models for life span extension by UPRmt and hormesis. Mitochondria (indicated in green) contain multiple mitochondrial genomes (black circles). A mitochondrial genome mutation (indicated by X) causes UPRmt and loss of membrane potential. These changes signal marking by Ref(2)P (indicated with red squares) and activation of the PINK/PARKIN pathway for fission of mitochondria and destruction by the autophagy pathway (cartooned in orange). Degradation products are recycled for use in biogenesis of new mitochondria. Induction of the UPRmt in young animals (hormesis) would inhibit the production of toxic metabolites including hormones and age pigment. Hormones promote sexual differentiation and the deleterious effects of many genes (through sexual antagonistic plieotropy, SAP). Sexual differentiation and SAP in turn inhibit mitochondrial turnover and maintenance, resulting in aging, oxidative stress and a toxic aging-associated UPRmt.

Mitochondrial maintenance failure in aging and role of sexual dimorphism

Arch Biochem Biophys. ;576:17-31.
Figure 3

Cardiac GRK2 protein levels are modulated by sexual hormones in rats. Cardiac lysates from female ovariectomized (OVX) animals and OVX rats, supplemented with 17β-estradiol (OVX + E2), were subjected to WB with antibodies against GRK2 and GAPDH, n = 5–6 (A) or to mRNA extraction and qPCR to assess adrbk1 levels (normalized to rpl32 and 18 s) n = 5–10 (B). Representative immunoblots and densitometric analysis are shown, results are represented as means ± SEM, statistical analyses were performed using one-way ANOVA followed by Bonferroni’s post-hoc test (A,B) * p < 0.05.

Cardiac GRK2 Protein Levels Show Sexual Dimorphism during Aging and Are Regulated by Ovarian Hormones

Cells. 2021 Mar;10(3):673.
Figure 5

Model for sex-specific regulation of mitochondrial maintenance pathways. Chromosomal sex determines the on/off state of the master regulator of dosage compensation (DC) the “Switch-Gene”: Sxl in Drosophila, sdc-2 in C. elegans, and Xist in humans. This sets DC to either the male (M) or female (F) state. Chromosomal sex also directs the expression the dsx-like gene in either the male or female state, which in turn regulates somatic sexual differentiation. Females exhibit relatively greater IIS and p53 activity (indicated in pink). Males exhibit relatively greater Foxo activity (indicated in blue). In C. elegans, DC negatively regulates expression of the X-linked gene akt-2, which is a positive regulator of IIS (indicated in green). In mammals, the gonadal hormones testosterone and estrogen activate a MAPK/PI3K/AKT/TOR signaling pathway that can activate IIS and potentially inhibit autophagy (indicated in orange).

Mitochondrial maintenance failure in aging and role of sexual dimorphism

Arch Biochem Biophys. ;576:17-31.
Figure 8

Serum total and free testosterone were assayed in young and middle-aged male rats before and after castration and hormone treatment. Hormones from intact young and middle-aged rats are shown in panels A and C. Hormones in the four groups 17 days after castration and treatment are shown in panels B and D. There was a significant main effect of testosterone treatment on total and free testosterone in samples collected at euthanasia (P < 0.001 for both). The bars represent the mean ± SEM. Abbreviations: T, testosterone; V, vehicle; MA, middle-aged.

Changes in Androgen Receptor, Estrogen Receptor alpha, and Sexual Behavior with Aging and Testosterone in Male Rats

Horm Behav. ;58(2):306-316.