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Select item 104570351.

The diversification of Caribbean Buxus in time and space: elevated speciation rates in lineages that accumulate nickel and spreading to other islands from Cuba in non-obligate ultramafic species

Pedro A González Gutiérrez, Susy Fuentes-Bazan, Vanessa Di Vincenzo, Rosalina Berazaín-Iturralde, Thomas Borsch

Ann Bot. 2023 Jun 6; 131(7): 1133–1147. Published online 2023 May 19. doi: 10.1093/aob/mcad063

PMCID:: PMC10457035

Abstract Article PDF–1.1M

Select item 88107872.

Buxus and Tetracentron genomes help resolve eudicot genome history

Andre S. Chanderbali, Lingling Jin, Qiaoji Xu, Yue Zhang, Jingbo Zhang, Shuguang Jian, Emily Carroll, David Sankoff, Victor A. Albert, Dianella G. Howarth, Douglas E. Soltis, Pamela S. Soltis

Nat Commun. 2022; 13: 643. Published online 2022 Feb 2. doi: 10.1038/s41467-022-28312-w

PMCID:: PMC8810787

Abstract Article PDF–8.3M

Select item 87464363.

Investigation of the Variability of Alkaloids in Buxus sempervirens L. Using Multivariate Data Analysis of LC/MS Profiles

Lara U. Szabó, Thomas J. Schmidt

Molecules. 2022 Jan; 27(1): 82. Published online 2021 Dec 23. doi: 10.3390/molecules27010082

PMCID:: PMC8746436

Abstract Article PDF–11M

Select item 52419354.

Antispasmodic, bronchodilator, vasorelaxant and cardiosuppressant effects of Buxus papillosa

Arif-ullah Khan, Shamsher Ali, Anwarul-Hassan Gilani, Manzoor Ahmed, Muhammad Iqbal Choudhary

BMC Complement Altern Med. 2017; 17: 54. Published online 2017 Jan 18. doi: 10.1186/s12906-017-1558-x

PMCID:: PMC5241935

Abstract Article PDF–1.6M

Select item 31741895.

Acetonic Extract of Buxus sempervirens Induces Cell Cycle Arrest, Apoptosis and Autophagy in Breast Cancer Cells

Ouardia Ait-Mohamed, Valentine Battisti, Véronique Joliot, Lauriane Fritsch, Julien Pontis, Souhila Medjkane, Catherine Redeuilh, Aazdine Lamouri, Christine Fahy, Mohamed Rholam, Djebbar Atmani, Slimane Ait-Si-Ali

PLoS One. 2011; 6(9): e24537. Published online 2011 Sep 15. doi: 10.1371/journal.pone.0024537

PMCID:: PMC3174189

Abstract Article PDF–1.0M

Select item 95335436.

A high-quality Buxus austro-yunnanensis (Buxales) genome provides new insights into karyotype evolution in early eudicots

Zhenyue Wang, Ying Li, Pengchuan Sun, Mingjia Zhu, Dandan Wang, Zhiqiang Lu, Hongyin Hu, Renping Xu, Jin Zhang, Jianxiang Ma, Jianquan Liu, Yongzhi Yang

BMC Biol. 2022; 20: 216. Published online 2022 Oct 4. doi: 10.1186/s12915-022-01420-1

PMCID:: PMC9533543

Abstract Article PDF–5.4M

Select item 102502727.

The influence of climate and population density on Buxus hyrcana potential distribution and habitat connectivity

Shirin Alipour, Łukasz Walas

J Plant Res. 2023; 136(4): 501–514. Published online 2023 Apr 28. doi: 10.1007/s10265-023-01457-5

PMCID:: PMC10250272

Abstract Article PDF–2.1M

Select item 74574978.

Disruption of microbial cell morphology by Buxus macowanii

B. Ngobeni, S. S. Mashele, N. J. Malebo, E. van der Watt, I. T. Manduna

BMC Complement Med Ther. 2020; 20: 266. Published online 2020 Aug 31. doi: 10.1186/s12906-020-03049-5

PMCID:: PMC7457497

Abstract Article PDF–2.1M

Select item 85373649.

Identification of Antiprotozoal Compounds from Buxus sempervirens L. by PLS-Prediction

Lara U. Szabó, Marcel Kaiser, Pascal Mäser, Thomas J. Schmidt

Molecules. 2021 Oct; 26(20): 6181. Published online 2021 Oct 13. doi: 10.3390/molecules26206181

PMCID:: PMC8537364

Abstract Article PDF–2.9M

Select item 758794110.

Target-Guided Isolation of O-tigloylcyclovirobuxeine-B from Buxussempervirens L. by Centrifugal Partition Chromatography

Lara U. Szabó, Thomas J. Schmidt

Molecules. 2020 Oct; 25(20): 4804. Published online 2020 Oct 19. doi: 10.3390/molecules25204804

PMCID:: PMC7587941

Abstract Article PDF–1.0M

Select item 454541211.

New Bioactive Lupane Triterpene Coumaroyl Esters Isolated from Buxus cochinchinensis

Li Pan, Ulyana Muñoz Acuña, Heebyung Chai, Hyun-Young Park, Tran Ngoc Ninh, Bui Van Thanh, Emilio F. Merino, Maria B. Cassera, L. Harinantenaina Rakotondraibe, Esperanza J. Carcache de Blanco, Djaja D. Soejarto, A. Douglas Kinghorn

Planta Med. Author manuscript; available in PMC 2016 Aug 1.

Published in final edited form as: Planta Med. 2015 Aug; 81(0): 1133–1140. Published online 2015 Jul 1. doi: 10.1055/s-0035-1546118

PMCID:: PMC4545412

Abstract Article PDF–1.0M

Select item 627343512.

Cytotoxicity of Triterpenoid Alkaloids from Buxus microphylla against Human Tumor Cell Lines

Shi-Tou Bai, Guo-Lei Zhu, Xing-Rong Peng, Jin-Run Dong, Mu-Yuan Yu, Jian-Chao Chen, Luo-Sheng Wan, Ming-Hua Qiu

Molecules. 2016 Sep; 21(9): 1125. Published online 2016 Aug 26. doi: 10.3390/molecules21091125

PMCID:: PMC6273435

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Select item 998628413.

Hydroalcoholic extract of Buxus sempervirens shows antiproliferative effect on melanoma, colorectal carcinoma and prostate cancer cells by affecting the autophagic flow

Anna Rita Volpe, Marco Carmignani, Patrizia Cesare

Front Pharmacol. 2023; 14: 1073338. Published online 2023 Feb 20. doi: 10.3389/fphar.2023.1073338

PMCID:: PMC9986284

Abstract Article PDF–3.9M

Select item 477176314.

Presence of Inulin-Type Fructo-Oligosaccharides and Shift from Raffinose Family Oligosaccharide to Fructan Metabolism in Leaves of Boxtree (Buxus sempervirens)

Wim Van den Ende, Marlies Coopman, Rudy Vergauwen, André Van Laere

Front Plant Sci. 2016; 7: 209. Published online 2016 Mar 1. doi: 10.3389/fpls.2016.00209

PMCID:: PMC4771763

Abstract Article PDF–636K

Select item 627115815.

Antiprotozoal Activity of Buxus sempervirens and Activity-Guided Isolation of O-tigloylcyclovirobuxeine-B as the Main Constituent Active against Plasmodium falciparum

Julia B. Althaus, Gerold Jerz, Peter Winterhalter, Marcel Kaiser, Reto Brun, Thomas J. Schmidt

Molecules. 2014 May; 19(5): 6184–6201. Published online 2014 May 15. doi: 10.3390/molecules19056184

PMCID:: PMC6271158

Abstract Article PDF–895K

Select item 425946016.

Development of polymorphic genic-SSR markers by cDNA library sequencing in boxwood, Buxus spp. (Buxaceae)

Chandra S. Thammina, Richard T. Olsen, Martha Malapi-Wight, Jo Anne Crouch, Margaret R. Pooler

Appl Plant Sci. 2014 Dec; 2(12): apps.1400095. Published online 2014 Nov 28. doi: 10.3732/apps.1400095

PMCID:: PMC4259460

Abstract Article PDF–503K

Select item 680207317.

Prokaryotic taxa play keystone roles in the soil microbiome associated with woody perennial plants in the genus Buxus

Nicholas LeBlanc, Jo Anne Crouch

Ecol Evol. 2019 Oct; 9(19): 11102–11111. Published online 2019 Aug 26. doi: 10.1002/ece3.5614

PMCID:: PMC6802073

Abstract Article PDF–1.4M

Select item 413165318.

Triterpenoid alkaloid derivatives from Buxus rugulosa

Yu-Xin Yan, Lin Zhou, Yun Sun, Jian-Chao Chen, Jia Su, Yan Li, Ming-Hua Qiu

Nat Prod Bioprospect. 2011 Oct; 1(2): 71–74. Published online 2011 Sep 21. doi: 10.1007/s13659-011-0010-z

PMCID:: PMC4131653

Abstract Article PDF–691K

Select item 822814119.

Antiprotozoal Nor-Triterpene Alkaloids from Buxus sempervirens L.

Lara U. Szabó, Marcel Kaiser, Pascal Mäser, Thomas J. Schmidt

Antibiotics (Basel) 2021 Jun; 10(6): 696. Published online 2021 Jun 10. doi: 10.3390/antibiotics10060696

PMCID:: PMC8228141

Abstract Article PDF–1.0M

Select item 922067120.

Potential Distribution of Invasive Boxwood Blight Pathogen (Calonectriapseudonaviculata) as Predicted by Process-Based and Correlative Models

Brittany S. Barker, Leonard Coop, Chuanxue Hong

Biology (Basel) 2022 Jun; 11(6): 849. Published online 2022 Jun 1. doi: 10.3390/biology11060849

PMCID:: PMC9220671

Abstract Article PDF–16M

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Figure 4Acetonic extract of Buxus induces autophagy in MCF7 cell line.

A. Transmission electron microscopy pictures of untreated and Buxus extract-treated MCF7 cells with IC₅₀ concentration for 72 h. Black arrows show degradative autophagic vesicles. White arrows show lucent electron vesicles. B. Immunoblots of total cell extracts isolated from MCF7 (treated and untreated, as indicated) probed with different antibodies demonstrating the occurrence of autophagy. β-actin has been used as a loading control. C. Immunofluorescence targeting LC3 obtained with untreated and Buxus extract-treated MCF7 cells (IC₅₀, 72 h). Magnification ×400. Ac Bux: acetonic Buxus extract.

Acetonic Extract of Buxus sempervirens Induces Cell Cycle Arrest, Apoptosis and Autophagy in Breast Cancer Cells

PLoS One. 2011;6(9):e24537.
Fig. 1Habit and genome assembly features of Buxus and Tetracentron.

Flowering branch of Buxus sinica (a) courtesy of PiPi; and leafy shoot of Tetracentron sinense (b) courtesy of Daderot. Hi-C contact heatmaps, intragenomic synteny with syntenic blocks colored according to the Ks scale, and Circos plots for Buxus (c) and Tetracentron (d). Concentric tracks in the Circos plots, from innermost outwards, show gene, Copia, and Gypsy retrotransposon densities per 1 Mb, and chromosomes, while ribbons connect inter-chromosomal syntenic regions. Source data underlying Fig. 1c, d are provided as a Source data file.

Buxus and Tetracentron genomes help resolve eudicot genome history

Nat Commun. 2022;13:643.
Figure 1Cytotoxic effects of the acetonic extract of Buxus sempervirens L. towards breast cancer MCF7 and MCF10CA1a cells.

A. IC₅₀ determined by the dose-response curves obtained by the MTT assay. B. C. D. and E. Different cell shapes exhibited by MCF7, MCF10CA1a, T47D, MDA-MB-435 and BT-20, respectively, treated with Buxus extract at their respective IC₅₀ during 72 h. Left panel: phase contrast images; Right panel: anti-α-tubulin fluorescence staining. Control cells are treated with vehicle DMSO (magnification ×200). Ac Bux: acetonic Buxus extract.

Acetonic Extract of Buxus sempervirens Induces Cell Cycle Arrest, Apoptosis and Autophagy in Breast Cancer Cells

PLoS One. 2011;6(9):e24537.
Figure 5Acetonic extract of Buxus induces autophagy in MCF10CA1a cell line.

A. Transmission electron microscopy pictures of untreated and Buxus extract-treated MCF10CA1a cells (IC₅₀, 72 h). Black arrows show degradative autophagic vesicles. White arrows show damaged mitochondria. B. Immunoblots of total cell extracts isolated from MCF10CA1a (treated and untreated, as indicated) probed with different antibodies demonstrating the occurrence of autophagy. β-actin has been used as a loading control. C. Immunofluorescence targeting LC3 obtained with untreated and treated MCF10CA1a cells (IC₅₀, 72 h). Magnification ×400. Ac Bux: acetonic Buxus extract.

Acetonic Extract of Buxus sempervirens Induces Cell Cycle Arrest, Apoptosis and Autophagy in Breast Cancer Cells

PLoS One. 2011;6(9):e24537.

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Buxus (958)
PMC
RBM42 [Rousettus aegyptiacus]
RBM42 [Rousettus aegyptiacus]
Gene ID:107497662

Gene
NEK9 [Crocodylus porosus]
NEK9 [Crocodylus porosus]
Gene ID:109321268

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