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Select item 106183881.

Tautomeric equilibrium and spectroscopic properties of 8-azaguanine revealed by quantum chemistry methods

Maciej Maciejczyk, Maciej Pyrka

Eur Biophys J. 2023; 52(6-7): 545–557. Published online 2023 Jul 28. doi: 10.1007/s00249-023-01672-x

PMCID:: PMC10618388

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Select item 98713252.

Identification of selective hepatitis delta virus ribozyme inhibitors by high-throughput screening of small molecule libraries

Eirini D. Tseligka, Stéphanie Conzelmann, Yves Cambet, Tifany Schaer, Francesco Negro, Sophie Clément

JHEP Rep. 2023 Mar; 5(3): 100652. Published online 2022 Dec 17. doi: 10.1016/j.jhepr.2022.100652

PMCID:: PMC9871325

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Select item 5476823.

Incorporation of 8-Azaguanine and Guanine by Cladosporium resinae

R. L. Smith, Joan C. Harrill

Appl Microbiol. 1968 Oct; 16(10): 1454–1456. doi: 10.1128/am.16.10.1454-1456.1968

PMCID:: PMC547682

Summary Page Browse PDF–387K

Select item 3147834.

EFFECT OF 8-AZAGUANINE ON GROWTH AND VIABILITY OF BACILLUS MEGATERIUM

R. Mangalo, J. T. Wachsman

J Bacteriol. 1962 Jan; 83(1): 27–34. doi: 10.1128/jb.83.1.27-34.1962

PMCID:: PMC314783

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Select item 62741825.

Site-Selective Ribosylation of Fluorescent Nucleobase Analogs Using Purine-Nucleoside Phosphorylase as a Catalyst: Effects of Point Mutations

Alicja Stachelska-Wierzchowska, Jacek Wierzchowski, Agnieszka Bzowska, Beata Wielgus-Kutrowska

Molecules. 2016 Jan; 21(1): 44. Published online 2015 Dec 28. doi: 10.3390/molecules21010044

PMCID:: PMC6274182

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USE OF 8-AZAGUANINE FOR THE ISOLATION OF AUXOTROPHIC MUTANTS OF BACILLUS MEGATERIUM

J. T. Wachsman, R. Mangalo

J Bacteriol. 1962 Jan; 83(1): 35–37. doi: 10.1128/jb.83.1.35-37.1962

PMCID:: PMC314784

Summary Page Browse PDF–385K

Select item 71091237.

Nitric oxide as a source for bacterial triazole biosynthesis

Guiyun Zhao, Yuan-Yang Guo, Shunyu Yao, Xinjie Shi, Longxian Lv, Yi-Ling Du

Nat Commun. 2020; 11: 1614. Published online 2020 Mar 31. doi: 10.1038/s41467-020-15420-8

PMCID:: PMC7109123

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DIFFERENTIATION OF PATHOGENIC AND SAPROPHYTIC LEPTOSPIRES WITH 8-AZAGUANINE

Russell C. Johnson, Palmer Rogers

J Bacteriol. 1964 Dec; 88(6): 1618–1623. doi: 10.1128/jb.88.6.1618-1623.1964

PMCID:: PMC277463

Summary Page Browse PDF–782K

Select item 22247029.

Chemical and Morphological Studies of Bacterial Spore Formation : III. The Effect of 8-Azaguanine on Spore and Parasporal Protein Formation in Bacillus cereus var. Alesti

I. Elizabeth Young, Philip C. Fitz-James

J Biophys Biochem Cytol. 1959 Dec 1; 6(3): 499–506. doi: 10.1083/jcb.6.3.499

PMCID:: PMC2224702

Summary PDF–627K

Select item 31613810.

Effect of 8-Azaguanine on the Transition from Vegetative Growth to Presporulation in Bacillus cereus

D. P. Stahly, V. R. Srinivasan, H. Orin Halvorson

J Bacteriol. 1966 May; 91(5): 1875–1882. doi: 10.1128/jb.91.5.1875-1882.1966

Correction in:: J Bacteriol. 1966 Aug; 92(2): 528.

PMCID:: PMC316138

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Select item 27708911.

ACCUMULATION OF RIBONUCLEIC ACID IN BACTERIAL NUCLEAR PREPARATIONS DURING TREATMENT OF WHOLE CELLS WITH 8-AZAGUANINE, TETRACYCLINES, AND OTHER INHIBITORS

David H. Ezekiel

J Bacteriol. 1964 Apr; 87(4): 755–760. doi: 10.1128/jb.87.4.755-760.1964

PMCID:: PMC277089

Summary Page Browse PDF–740K

Select item 121282412.

8-Azaguanine Resistance in Mammalian Cells I. Hypoxanthine-Guanine Phosphoribosyltransferase

F. D. Gillin, D. J. Roufa, A. L. Beaudet, C. T. Caskey

Genetics. 1972 Oct; 72(2): 239–252. doi: 10.1093/genetics/72.2.239

PMCID:: PMC1212824

Summary PDF–847K

Select item 627005113.

Enzymatic Synthesis of Highly Fluorescent 8-Azapurine Ribosides Using a Purine Nucleoside Phosphorylase Reverse Reaction: Variable Ribosylation Sites

Alicja Stachelska-Wierzchowska, Jacek Wierzchowski, Beata Wielgus-Kutrowska, Goran Mikleušević

Molecules. 2013 Oct; 18(10): 12587–12598. Published online 2013 Oct 11. doi: 10.3390/molecules181012587

PMCID:: PMC6270051

Article PDF–414K

Select item 41125814.

Quantitative forward mutation assay in Salmonella typhimurium using 8-azaguanine resistance as a genetic marker.

T R Skopek, H L Liber, J J Krolewski, W G Thilly

Proc Natl Acad Sci U S A. 1978 Jan; 75(1): 410–414. doi: 10.1073/pnas.75.1.410

PMCID:: PMC411258

Summary Page Browse PDF–938K

Select item 25204015.

Defective Guanine Uptake in an 8-Azaguanine-resistant Mutant of Salmonella typhimurium

Jayendra H. Thakar, Gurudutt P. Kalle

J Bacteriol. 1968 Feb; 95(2): 458–464. doi: 10.1128/jb.95.2.458-464.1968

PMCID:: PMC252040

Summary Page Browse PDF–918K

Select item 16544616.

Characterisation of methionine adenosyltransferase from Mycobacterium smegmatis and M. tuberculosis

Bradley J Berger, Marvin H Knodel

BMC Microbiol. 2003; 3: 12. Published online 2003 Jun 16. doi: 10.1186/1471-2180-3-12

PMCID:: PMC165446

Article PDF–406K

Select item 209516317.

Effect of 8-Azaguanine on the Synthesis of Vaccinia Virus

J. Cogniaux-Le Clerc

Br J Exp Pathol. 1962 Dec; 43(6): 587–595.

Correction in:: Br J Exp Pathol. 1963 Feb; 44(1): ix.2.

PMCID:: PMC2095163

Summary Page Browse PDF–952K

Select item 38853118.

Expression of Purine Overproduction in a Series of 8-Azaguanine-Resistant Diploid Human Lymphoblast Lines

Julia E. Lever, George Nuki, J. Edwin Seegmiller

Proc Natl Acad Sci U S A. 1974 Jul; 71(7): 2679–2683. doi: 10.1073/pnas.71.7.2679

PMCID:: PMC388531

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Select item 54735519.

Use of 8-azaguanine to differentiate leptospires isolated from Iowa surface waters.

J L Braun, W F McCulloch

Appl Microbiol. 1968 Jan; 16(1): 174–175. doi: 10.1128/am.16.1.174-175.1968

PMCID:: PMC547355

Summary Page Browse PDF–228K

Select item 888360420.

Blocking I—Ag⁷ class II major histocompatibility complex by drug-like small molecules alleviated Sjögren’s syndrome in NOD mice

Shivai Gupta, Danmeng Li, David A. Ostrov, Cuong Q. Nguyen

Life Sci. Author manuscript; available in PMC 2022 Feb 28.

Published in final edited form as: Life Sci. 2022 Jan 1; 288: 120182. Published online 2021 Nov 27. doi: 10.1016/j.lfs.2021.120182

PMCID:: PMC8883604

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PMC Images search for 8-azaguanine【药】

FIGURE 5

Proposed biosynthetic pathway to 8-azaguanine.

Identification of 8-Azaguanine Biosynthesis–Related Genes Provides Insight Into the Enzymatic and Non-enzymatic Biosynthetic Pathway for 1,2,3-Triazole

Front Bioeng Biotechnol. 2020;8:603514.
FIGURE 1

(A) The structures of 8-azaguanine (1) and guanine. (B) Organizations of the 8-azg biosynthetic gene clusters and the comparison with ptn gene cluster.

Identification of 8-Azaguanine Biosynthesis–Related Genes Provides Insight Into the Enzymatic and Non-enzymatic Biosynthetic Pathway for 1,2,3-Triazole

Front Bioeng Biotechnol. 2020;8:603514.
Fig. 1Biosynthetic investigation of 8-azaguanine (1).

a The structures of 1,2,3-triazole, 8-azaguanine (1) and guanine. b The biosynthetic gene cluster (ptn cluster) of 8-azaguanine. c Heterologous expression and in vivo reconstitution of the 1 biosynthetic pathway in S. albus J1074. The extracted ion chromatograms (EIC) for 1 (m/z 151, [M−H]⁻), 2 (m/z 152, [M−H]⁻), 3 (m/z 283, [M−H]⁻) from LC-MS analysis were presented. Note: three independent tests were taken, the ratio of 1 to 2 varies from batches to batches, which could be attributed to the fluctuation of host metabolism, as 2 derives from 1 by a host enzyme (guanine deaminase). d LC-HR-ESI-MS analysis of 8-azaguanine (1) and 8-azaxanthine (2) from stable isotope-labeled precursors feeding experiments. e Isotope-labeling pattern of 1 and 2 based on results from (d).

Nitric oxide as a source for bacterial triazole biosynthesis

Nat Commun. 2020;11:1614.
Figure 6

The structures of 8-azaguanine and azathioprine. From right to left: the adenine portion of ATP, 8-azaguanine, and azathioprine.

Characterisation of methionine adenosyltransferase from Mycobacterium smegmatis and M. tuberculosis

BMC Microbiol. 2003;3:12-12.

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