3-4-5TRIFLUORONITROBENZENE - PMC

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The following term was not found in PMC: 5TRIFLUORONITROBENZENE.

Select item 53442551.

Design, Synthesis and Biochemical Evaluation of Novel Selective Estrogen Receptor Ligand Conjugates Incorporating an Endoxifen-Combretastatin Hybrid Scaffold

Niall O. Keely, Miriam Carr, Bassem Yassin, Gloria Ana, David G. Lloyd, Daniela Zisterer, Mary J. Meegan

Biomedicines. 2016 Sep; 4(3): 15. Published online 2016 Jul 20. doi: 10.3390/biomedicines4030015

PMCID:: PMC5344255

Article PDF–2.2M

Select item 90245212.

4-Heteroaryl Substituted Amino-3,5-Dicyanopyridines as New Adenosine Receptor Ligands: Novel Insights on Structure-Activity Relationships and Perspectives

Daniela Catarzi, Flavia Varano, Erica Vigiani, Sara Calenda, Fabrizio Melani, Katia Varani, Fabrizio Vincenzi, Silvia Pasquini, Natascia Mennini, Giulia Nerli, Diego Dal Ben, Rosaria Volpini, Vittoria Colotta

Pharmaceuticals (Basel) 2022 Apr; 15(4): 478. Published online 2022 Apr 14. doi: 10.3390/ph15040478

PMCID:: PMC9024521

Article PDF–9.7M

Select item 60174803.

Synthesis of Polyheterocyclic Pyrrolo[3,4-b]pyridin-5-ones via a One-Pot (Ugi-3CR/aza Diels-Alder/N-acylation/aromatization/S_N2) Process. A Suitable Alternative towards Novel Aza-Analogues of Falipamil

Angel Zamudio-Medina, Ailyn N. García-González, Genesis K. Herrera-Carrillo, Daniel Zárate-Zárate, Adriana Benavides-Macías, Joaquín Tamariz, Ilich A. Ibarra, Alejandro Islas-Jácome, Eduardo González-Zamora

Molecules. 2018 Apr; 23(4): 763. Published online 2018 Mar 27. doi: 10.3390/molecules23040763

PMCID:: PMC6017480

Article PDF–27M

Select item 101304764.

PI3Kα Translocation Mediates Nuclear PtdIns(3,4,5)P₃ Effector Signaling in Colorectal Cancer

Michelle Palmieri, Bruno Catimel, Dmitri Mouradov, Anuratha Sakthianandeswaren, Eugene Kapp, Ching-Seng Ang, Nicholas A. Williamson, Cameron J. Nowell, Michael Christie, Jayesh Desai, Peter Gibbs, Antony W. Burgess, Oliver M. Sieber

Mol Cell Proteomics. 2023 Apr; 22(4): 100529. Published online 2023 Mar 16. doi: 10.1016/j.mcpro.2023.100529

PMCID:: PMC10130476

Article PDF–5.8M

Select item 86249985.

Synthesis and Antiproliferative Evaluation of 3-Chloroazetidin-2-ones with Antimitotic Activity: Heterocyclic Bridged Analogues of Combretastatin A-4

Azizah M. Malebari, Shu Wang, Thomas F. Greene, Niamh M. O’Boyle, Darren Fayne, Mohemmed Faraz Khan, Seema M. Nathwani, Brendan Twamley, Thomas McCabe, Daniela M. Zisterer, Mary J. Meegan

Pharmaceuticals (Basel) 2021 Nov; 14(11): 1119. Published online 2021 Oct 31. doi: 10.3390/ph14111119

PMCID:: PMC8624998

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Select item 90324716.

Discovery of 5,7-Dimethoxy-2-(3,4,5-trimethoxyphenoxy)-chromen-4-one with Lipid Lowering Effects in Hepatocytes

Yi-Han Chang, Chia-Hung Yen, Chih-Chung Lai, Hsuan-Yu Lai, Hsin-Yi Hung

Pharmaceuticals (Basel) 2022 Apr; 15(4): 449. Published online 2022 Apr 4. doi: 10.3390/ph15040449

PMCID:: PMC9032471

Article PDF–1.5M

Select item 56782817.

PTEN Regulates PI(3,4)P₂ Signaling Downstream of Class I PI3K

Mouhannad Malek, Anna Kielkowska, Tamara Chessa, Karen E. Anderson, David Barneda, Pınar Pir, Hiroki Nakanishi, Satoshi Eguchi, Atsushi Koizumi, Junko Sasaki, Véronique Juvin, Vladimir Y. Kiselev, Izabella Niewczas, Alexander Gray, Alexandre Valayer, Dominik Spensberger, Marine Imbert, Sergio Felisbino, Tomonori Habuchi, Soren Beinke, Sabina Cosulich, Nicolas Le Novère, Takehiko Sasaki, Jonathan Clark, Phillip T. Hawkins, Len R. Stephens

Mol Cell. 2017 Nov 2; 68(3): 566–580.e10. doi: 10.1016/j.molcel.2017.09.024

PMCID:: PMC5678281

Article

Select item 93909198.

Angiotensin-(3–4) normalizes the elevated arterial blood pressure and abnormal Na⁺/energy handling associated with chronic undernutrition by counteracting the effects mediated by type 1 angiotensin II receptors

Amaury Pereira-Acácio, João P. M. Veloso-Santos, Luiz F. Nossar, Gloria Costa-Sarmento, Humberto Muzi-Filho, Adalberto Vieyra

PLoS One. 2022; 17(8): e0273385. Published online 2022 Aug 19. doi: 10.1371/journal.pone.0273385

PMCID:: PMC9390919

Article PDF–3.6M

Select item 110543039.

Design and Synthesis of Novel N-Benzylidene Derivatives of 3-Amino-4-imino-3,5-dihydro-4H-chromeno[2,3-d]pyrimidine under Microwave, In Silico ADME Predictions, In Vitro Antitumoral Activities and In Vivo Toxicity

Sirine Karoui, Marwa Dhiabi, Mehdi Fakhfakh, Souhir Abid, Emmanuelle Limanton, Rémy Le Guével, Thierry D. Charlier, Anthony Mainguy, Olivier Mignen, Ludovic Paquin, Houcine Ammar, Jean-Pierre Bazureau

Pharmaceuticals (Basel) 2024 Apr; 17(4): 458. Published online 2024 Apr 2. doi: 10.3390/ph17040458

PMCID:: PMC11054303

Article PDF–18M

Select item 799830910.

Structural-Based Optimizations of the Marine-Originated Meridianin C as Glucose Uptake Agents by Inhibiting GSK-3β

Shuwen Han, Chunlin Zhuang, Wei Zhou, Fener Chen

Mar Drugs. 2021 Mar; 19(3): 149. Published online 2021 Mar 12. doi: 10.3390/md19030149

PMCID:: PMC7998309

Article PDF–2.1M

Select item 1005661111.

Synthesis and Biological Evaluation of 3-Amino-4,4-Dimethyl Lithocholic Acid Derivatives as Novel, Selective, and Cellularly Active Allosteric SHP1 Activators

Huiqing Chen, Zekun Liu, Lixin Gao, Li-Fang Yu, Yubo Zhou, Jie Tang, Jia Li, Fan Yang

Molecules. 2023 Mar; 28(6): 2488. Published online 2023 Mar 8. doi: 10.3390/molecules28062488

PMCID:: PMC10056611

Article PDF–7.0M

Select item 996573112.

First X-ray Crystal Structure Characterization, Computational Studies, and Improved Synthetic Route to the Bioactive 5-Arylimino-1,3,4-thiadiazole Derivatives

Ziad Moussa, Alejandro Perez Paz, Zaher M. A. Judeh, Ahmed Alzamly, Haythem A. Saadeh, Basim H. Asghar, Sara Alsaedi, Bayan Masoud, Salama Almeqbaali, Saeda Estwani, Amna Aljaberi, Munirah M. Al-Rooqi, Saleh A. Ahmed

Int J Mol Sci. 2023 Feb; 24(4): 3759. Published online 2023 Feb 13. doi: 10.3390/ijms24043759

PMCID:: PMC9965731

Article PDF–9.7M

Select item 996220013.

Selectively Modified Lactose and N-Acetyllactosamine Analogs at Three Key Positions to Afford Effective Galectin-3 Ligands

Shuay Abdullayev, Priyanka Kadav, Purnima Bandyopadhyay, Francisco Javier Medrano, Gabriel A. Rabinovich, Tarun K. Dam, Antonio Romero, René Roy

Int J Mol Sci. 2023 Feb; 24(4): 3718. Published online 2023 Feb 13. doi: 10.3390/ijms24043718

PMCID:: PMC9962200

Article PDF–7.1M

Select item 883965814.

Design and Activity of Novel Oxadiazole Based Compounds That Target Poly(ADP-ribose) Polymerase

Divakar Vishwanath, Swamy S. Girimanchanaika, Dukanya Dukanya, Shobith Rangappa, Ji-Rui Yang, Vijay Pandey, Peter E. Lobie, Basappa Basappa

Molecules. 2022 Feb; 27(3): 703. Published online 2022 Jan 21. doi: 10.3390/molecules27030703

PMCID:: PMC8839658

Article PDF–6.4M

Select item 1014608115.

Synthesis, Anticancer, Antimicrobial and Antioxidant Potential of Novel 4-(Substituted phenyl-1,3,4-oxadiazol/thiadiazol-2-yl)-4-(4-substituted phenyl) Azetidin-2-One Derivatives

Davinder Kumar, Navidha Aggarwal, Virender Kumar, Harsh Kumar, Aakash Deep, Shabana Bibi, Hitesh Chopra, Rakesh Kumar Marwaha, Abdulrahman Alshammari, Metab Alharbi, Abdul Hayee

Pharmaceuticals (Basel) 2023 Apr; 16(4): 517. Published online 2023 Mar 30. doi: 10.3390/ph16040517

PMCID:: PMC10146081

Article PDF–2.9M

Select item 822319516.

Discovery of ( ±)-3-(1H-pyrazol-1-yl)-6,7-dihydro-5H-[1,2,4]triazolo[3,4-b][1,3,4] thiadiazine derivatives with promising in vitro anticoronavirus and antitumoral activity

Parameshwara Chary Jilloju, Leentje Persoons, Sathish Kumar Kurapati, Dominique Schols, Steven De Jonghe, Dirk Daelemans, Rajeswar Rao Vedula

Mol Divers. 2022; 26(3): 1357–1371. Published online 2021 Jun 24. doi: 10.1007/s11030-021-10258-8

PMCID:: PMC8223195

Article PDF–2.2M

Select item 884074217.

Synthesis, Structure–Activity Relationships, and Antiviral Profiling of 1-Heteroaryl-2-Alkoxyphenyl Analogs as Inhibitors of SARS-CoV-2 Replication

Dorothée Bardiot, Laura Vangeel, Mohamed Koukni, Philippe Arzel, Marleen Zwaagstra, Heyrhyoung Lyoo, Patrick Wanningen, Shamshad Ahmad, Linlin Zhang, Xinyuanyuan Sun, Adrien Delpal, Cecilia Eydoux, Jean-Claude Guillemot, Eveline Lescrinier, Hugo Klaassen, Pieter Leyssen, Dirk Jochmans, Karolien Castermans, Rolf Hilgenfeld, Colin Robinson, Etienne Decroly, Bruno Canard, Eric J. Snijder, Martijn J. van Hemert, Frank van Kuppeveld, Patrick Chaltin, Johan Neyts, Steven De Jonghe, Arnaud Marchand

Molecules. 2022 Feb; 27(3): 1052. Published online 2022 Feb 4. doi: 10.3390/molecules27031052

PMCID:: PMC8840742

Article PDF–1.1M

Select item 663083218.

3-Vinylazetidin-2-Ones: Synthesis, Antiproliferative and Tubulin Destabilizing Activity in MCF-7 and MDA-MB-231 Breast Cancer Cells

Shu Wang, Azizah M. Malebari, Thomas F. Greene, Niamh M. O’Boyle, Darren Fayne, Seema M. Nathwani, Brendan Twamley, Thomas McCabe, Niall O. Keely, Daniela M. Zisterer, Mary J. Meegan

Pharmaceuticals (Basel) 2019 Jun; 12(2): 56. Published online 2019 Apr 11. doi: 10.3390/ph12020056

PMCID:: PMC6630832

Article PDF–7.8M

Select item 792635219.

Synthesis, Characterization and In Vitro Evaluation of Novel 5-Ene-thiazolo[3,2-b][1,2,4]triazole-6(5H)-ones as Possible Anticancer Agents

Serhii Holota, Sergiy Komykhov, Stepan Sysak, Andrzej Gzella, Andriy Cherkas, Roman Lesyk

Molecules. 2021 Feb; 26(4): 1162. Published online 2021 Feb 22. doi: 10.3390/molecules26041162

PMCID:: PMC7926352

Article PDF–2.1M

Select item 883907420.

Antimicrobial Activity and DFT Studies of a Novel Set of Spiropyrrolidines Tethered with Thiochroman-4-one/Chroman-4-one Scaffolds

Nourhène Chouchène, Amani Toumi, Sarra Boudriga, Hayet Edziri, Mansour Sobeh, Mohamed A. O. Abdelfattah, Moheddine Askri, Michael Knorr, Carsten Strohmann, Lukas Brieger, Armand Soldera

Molecules. 2022 Feb; 27(3): 582. Published online 2022 Jan 18. doi: 10.3390/molecules27030582

PMCID:: PMC8839074

Article PDF–3.2M

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