BioAssays, Active for PubChem Compound (Select 3006531) - PubChem BioAssay - NCBI

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Select item 18762781.

Inhibition of MEK2 (unknown origin)

Source:: ChEMBL

Protein Target:: Dual specificity mitogen-activated protein kinase kinase 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1876278

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 18762772.

Inhibition of MEK1 (unknown origin)

Source:: ChEMBL

Protein Target:: Dual specificity mitogen-activated protein kinase kinase 1

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1876277

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 18761973.

Antiviral activity against Influenza A virus (MB1 H5N1)

Source:: ChEMBL

Assay data:1 Active, 1 Tested

AID:: 1876197

Summary Compounds, Active PubMed Citation

Select item 18761964.

Antiviral activity against Influenza A virus (RB1 H1N1)

Source:: ChEMBL

Assay data:1 Active, 1 Tested

AID:: 1876196

Summary Compounds, Active PubMed Citation

Select item 18760295.

Antiviral activity against influenza A virus (H1N1v) infected in human A549 cells

Source:: ChEMBL

Assay data:1 Active, 1 Tested

AID:: 1876029

Summary Compounds, Active PubMed Citation

Select item 18760276.

Inhibition of MEK2 (unknown origin)

Source:: ChEMBL

Protein Target:: Dual specificity mitogen-activated protein kinase kinase 2

Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested

AID:: 1876027

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 18760267.

Inhibition of MEK1 (unknown origin)

Source:: ChEMBL

Protein Target:: Dual specificity mitogen-activated protein kinase kinase 1

Assay data:3 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested

AID:: 1876026

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 17458558.

NCATS anti-infectives library activity on the primary C. elegans qHTS viability assay

Source:: National Center for Advancing Translational Sciences (NCATS)

Assay data:48 Active, 86 Activity ≤ 1 µM, 637 Tested

AID:: 1745855

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Depositor

Select item 16711909.

Primary qHTS assay for inhibitors of human arachidonate 12S-lipoxygenase (ALOX12): Round 2

Source:: National Center for Advancing Translational Sciences (NCATS)

Protein Target:: Polyunsaturated fatty acid lipoxygenase ALOX12

Assay data:6069 Active, 5332 Activity ≤ 1 µM, 575118 Tested

AID:: 1671190

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Target

Select item 163753810.

Inhibition of recombinant full length human N-terminal GST-tagged C-terminal His6-tagged MEK1 expressed in Escherichia coli using myelin basic protein as substrate in presence of activated BRAF and ERK2 by ELISA

Source:: ChEMBL

Protein Target:: Dual specificity mitogen-activated protein kinase kinase 1

Assay data:9 Active, 2 Activity ≤ 1 µM, 13 Tested

AID:: 1637538

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 156912911.

Inhibition of recombinant N-terminal GST-tagged human BRAF (433-726 residues) expressed in baculovirus infected sf21 insect cells/recombinant human full length N-terminal GST-tagged MEK1 expressed in Escherichia coli cascading pathway assessed as reduction in MEK1 phosphorylation incubated for 2 hrs by HTRF assay relative to control

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 µM, 19 Tested

AID:: 1569129

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 156912512.

Antiproliferative activity against human A375 cells assessed as cell viability incubated for 72 hrs by cell titer-glo luminescent cell viability assay (Rvb = > 100 uM)

Source:: ChEMBL

Assay data:2 Active, 7 Tested

AID:: 1569125

Summary Compounds, Active PubMed Citation

Select item 156912313.

Antiproliferative activity against human HL60 cells assessed as cell viability incubated for 72 hrs by cell titer-glo luminescent cell viability assay (Rvb = > 100 uM)

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 µM, 7 Tested

AID:: 1569123

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 134706314.

Diffuse intrinsic pontine glioma (SU-DIPG-IV) cell line screen of MIPE4.0 library: viability qHTS assay using CellTiter-Glo

Source:: NIH/NCATS RNAi

Assay data:585 Active, 1912 Tested

AID:: 1347063

Summary Compounds, Active Related BioAssays by Depositor

Select item 130661015.

Inhibition of N-terminal GST-tagged human BRAF/MEK1/RAF1 Y340D/Y341D double mutant measured after 2 hrs in presence of ATP by TR-FRET assay

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase B-raf

Assay data:20 Active, 14 Activity ≤ 1 µM, 29 Tested

AID:: 1306610

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 130660816.

Inhibition of N-terminal GST-tagged human MEK1/ERK1/RAF1 Y340D/Y341D double mutant measured after 2 hrs in presence of ATP by TR-FRET assay

Source:: ChEMBL

Assay data:2 Active, 1 Activity ≤ 1 µM, 20 Tested

AID:: 1306608

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 130661717.

Induction of MEK1/2 phosphorylation in human rhabdomyosarcoma cells infected with EV71 BC08 GU475127 at 30 uM pre-treated for 1 hr followed by viral infection measured after 24 hrs by western blotting analysis

Source:: ChEMBL

Protein Targets:: Dual specificity mitogen-activated protein kinase kinase 1; ...
Total:: 2

Assay data:1 Active, 1 Tested

AID:: 1306617

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 130661518.

Inhibition of MEK1 phosphorylation in human rhabdomyosarcoma cells infected with EV71 BC08 GU475127 assessed as inhibition of ERK1/2 phosphorylation at 30 uM pre-treated for 1 hr followed by viral infection measured after 24 hrs by western blotting analysis

Source:: ChEMBL

Protein Target:: Dual specificity mitogen-activated protein kinase kinase 1

Assay data:1 Active, 1 Tested

AID:: 1306615

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 126048719.

Inhibition of ERK in cultured rat retinal ganglion cells exposed to oxygen glucose deprivation condition for 3 hrs assessed as protection against TRPM7-mediated cell death at by propidium iodide uptake assay

Source:: ChEMBL

Protein Targets:: Mitogen-activated protein kinase 1; ...
Total:: 2

Assay data:1 Active, 1 Tested

AID:: 1260487

Summary Compounds, Active Related BioAssays by Target

Select item 106713320.

Inhibition of MEK-mediated ERK1/2 phosphorylation in mouse RAS-3T3 cells at 10 to 40 uM by Western-blot analysis

Source:: ChEMBL

Assay data:1 Active, 1 Tested

AID:: 1067133

Summary Compounds, Active PubMed Citation

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Proteins (7)
BioAssays with protein sequences specified as targets

BioActivity

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BioAssays with compounds reported as validated chemical probes

Active Compounds (64)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (12)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (38)
BioAssays with the active concentration of tested reagents less than 1 micromolar

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Confirmatory (44)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (1)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose

Assay Project (7)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

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Literature Extraction (52)
BioAssays extracted from the literature
NIH MLP (9)
BioAssays deposited by the NIH Molecular Libraries Program
Other (3)
BioAssays deposited by other experimentalists

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