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Summary
Reaction Biology 33P Hotspot assay from US Patent US20240010634: "PYRIMIDINYL SULFONAMIDES AS INHIBITORS OF ACK1/TNK2 TYROSINE KINASE"
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Selectivity interaction (Z?-LYTE assay (SelectScreen Invitrogen)) EUB0000690a TNK2
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Selectivity interaction (Kinase panel (KiNativ method in HeLa cells)) EUB0000122b TNK2
Assay data:1 Tested
SummaryRelated BioAssays by Target
Selectivity interaction (KinaseProfiler? (Millipore)) EUB0000640a TNK2
Selectivity interaction (Enzymatic assay) EUB0000609a TNK2
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of ACK1 (unknown origin)
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of ACK1 (unknown origin) assessed as residual activity at 1 uM by radiometric 33 PanQuinase assay relative to control
Inhibition of TNK2 (unknown origin)
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of TNK2 (unknown origin) assessed as residual activity at 10 uM incubated for 1 hr by KinomeScan analysis relative to control
TNK2 DiscoveRx kinase panel
ACK1(h) Kinase panel
Inhibition of ACK1 (unknown origin) at 1 uM
Inhibition of ACK1 (unknown origin) at 0.1 uM using Poly (Glu,Tyr) 4:1 as substrate incubated for 1 hr in presence of ATP by ELISA relative to control
Binding affinity to wild-type human partial length TNK2 (S159 to D474 residues) expressed in bacterial expression system assessed as residual binding level at 100 nM by Kinomescan method relative to control
Inhibition Assay from US Patent US10464919: "Tricyclic derivative compound, method for preparing same, and pharmaceutical composition comprising same"
Assay data:103 Active, 2 Activity ≤ 1 nM, 103 Activity ≤ 1 µM, 103 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Enzyme-Linked Immunosorbent Assay from US Patent US10336734: "Inhibitors of ACK1/TNK2 tyrosine kinase"
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
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