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Summary
In Vitro Assay Dipeptidyl Peptidase IV. Fibroblast Activation Protein and Prolyl Oligopeptidase from US Patent US11707539: "FAP-targeted radiopharmaceuticals and imaging agents, and uses related thereto"
Assay data:89 Active, 7 Activity ≤ 1 nM, 89 Activity ≤ 1 µM, 89 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
EnPlex (purified enzyme activity assay) from US Patent US11559537: "Combination therapies using caspase-1 dependent anticancer agents and PGE2 antagonists"
Assay data:49 Active, 10 Activity ≤ 1 nM, 47 Activity ≤ 1 µM, 50 Tested
Pharmacological Activity Assay from US Patent US11337973: "Substituted [1,2,4]triazolo[4,3-A]pyrazines as prolyl endopeptidase inhibitors"
Assay data:28 Active, 12 Activity ≤ 1 nM, 28 Activity ≤ 1 µM, 28 Tested
Enzymatic Assay from US Patent US9346814: "FAP inhibitors"
Assay data:45 Active, 32 Activity ≤ 1 µM, 49 Tested
POP Inhibition Assays from US Patent US10125097: "1- [1-(benzoyl)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carbonitrile derivatives"
Assay data:18 Active, 16 Activity ≤ 1 µM, 18 Tested
Inhibition of human PREP expressed in N2A cells assessed as decrease in alpha-synuclein dimerization by measuring decrease in luminescence at 10 uM measured after 4 hrs by protein fragment complementation assay relative to control
Assay data:20 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of PREP (unknown origin) using AMC substrate by fluorometric assay
Assay data:47 Active, 3 Activity ≤ 1 nM, 37 Activity ≤ 1 µM, 50 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of recombinant human His-tagged Prolyl oligopeptidase expressed in Escherichia coli expression system preincubated with enzyme for 15 mins followed by addition of ZGP-AMC substrate measured after 1 hr by fluorescence assay
Assay data:1 Tested
Inhibition of recombinant human Prolyl oligopeptidase expressed in Escherichia coli expression system using (Z)-Gly-Pro-p-nitroanilide as substrate preincubated with enzyme for 5 mins followed by substrate addition and measured for 30 mins by spectrophotometric analysis
Assay data:23 Tested
Inhibition of full length recombinant human POP expressed in Escherichia coli BL21 cells using Z-Gly-Pro-AMC as substrate measured for 5 mins
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of recombinant human POP assessed as affinity constant K(-2) pre-incubated for 2 hrs before addition of ZGP-pNA substrate and measured every 30 secs for first 60 mins followed by every 2 mins for next 5 hrs by dilution assay
Inhibition of recombinant human POP assessed as affinity constant K2 pre-incubated for 2 hrs before addition of ZGP-pNA substrate and measured every 30 secs for first 60 mins followed by every 2 mins for next 5 hrs by dilution assay
Inhibition of recombinant human POP pre-incubated for 2 hrs before addition of ZGP-pNA substrate by absorbance assay
Inhibition of recombinant human POP assessed as residence time pre-incubated for 30 mins before addition of ZGP-pNA substrate by absorbance assay
Assay data:5 Tested
Inhibition of recombinant human POP assessed as dissociation rate constant pre-incubated for 30 mins before addition of ZGP-pNA substrate by absorbance assay
Assay data:3 Tested
Inhibition of recombinant human POP assessed as association rate constant pre-incubated for 30 mins before addition of ZGP-pNA substrate by absorbance assay
Inhibition of recombinant human POP assessed as affinity constant of second step of inhibition pre-incubated for 2 hrs before addition of ZGP-pNA substrate and measured every 30 secs for first 60 mins followed by every 2 mins for next 5 hrs by dilution assay
Assay data:4 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
Inhibition of recombinant human POP assessed as affinity constant of first step of the binding event pre-incubated for 2 hrs before addition of ZGP-pNA substrate and measured every 30 secs for first 60 mins followed by every 2 mins for next 5 hrs by dilution assay
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of recombinant human POP pre-incubated for 30 mins before addition of ZGP-pNA substrate by absorbance assay
Assay data:9 Active, 1 Activity ≤ 1 nM, 8 Activity ≤ 1 µM, 11 Tested
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