Entry - *609563 - CARBOXYPEPTIDASE O; CPO - OMIM

 
 
* 609563

CARBOXYPEPTIDASE O; CPO


HGNC Approved Gene Symbol: CPO

Cytogenetic location: 2q33.3     Genomic coordinates (GRCh38): 2:206,939,518-206,969,474 (from NCBI)


TEXT

▼ Cloning and Expression

By searching databases for sequences similar to CPA1 (114850) and CPB1 (114852), Wei et al. (2002) identified a partial CPO cDNA encoding a carboxypeptidase catalytic domain with all residues involved in zinc coordination and substrate catalysis. The predicted active site differs from that of other carboxypeptidases, and the enzyme likely cleaves C-terminal acidic amino acids.


▼ Mapping

By genomic sequence analysis, Wei et al. (2002) mapped the CPO gene to chromosome 2.


▼ REFERENCES

  1. Wei, S., Segura, S., Vendrell, J., Aviles, F. X., Lanoue, E., Day, R., Feng, Y., Fricker, L. D. Identification and characterization of three members of the human metallocarboxypeptidase gene family. J. Biol. Chem. 277: 14954-14964, 2002. [PubMed: 11836249, related citations] [Full Text]


Creation Date:
Patricia A. Hartz : 8/31/2005
Edit History:
mgross : 08/31/2005

* 609563

CARBOXYPEPTIDASE O; CPO


HGNC Approved Gene Symbol: CPO

Cytogenetic location: 2q33.3     Genomic coordinates (GRCh38): 2:206,939,518-206,969,474 (from NCBI)


TEXT

Cloning and Expression

By searching databases for sequences similar to CPA1 (114850) and CPB1 (114852), Wei et al. (2002) identified a partial CPO cDNA encoding a carboxypeptidase catalytic domain with all residues involved in zinc coordination and substrate catalysis. The predicted active site differs from that of other carboxypeptidases, and the enzyme likely cleaves C-terminal acidic amino acids.


Mapping

By genomic sequence analysis, Wei et al. (2002) mapped the CPO gene to chromosome 2.


REFERENCES

  1. Wei, S., Segura, S., Vendrell, J., Aviles, F. X., Lanoue, E., Day, R., Feng, Y., Fricker, L. D. Identification and characterization of three members of the human metallocarboxypeptidase gene family. J. Biol. Chem. 277: 14954-14964, 2002. [PubMed: 11836249] [Full Text: https://doi.org/10.1074/jbc.M112254200]


Creation Date:
Patricia A. Hartz : 8/31/2005

Edit History:
mgross : 08/31/2005



NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: April 26, 2024