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CPO carboxypeptidase O [ Homo sapiens (human) ]

Gene ID: 130749, updated on 16-Mar-2024

Summary

Official Symbol
CPOprovided by HGNC
Official Full Name
carboxypeptidase Oprovided by HGNC
Primary source
HGNC:HGNC:21011
See related
Ensembl:ENSG00000144410 MIM:609563; AllianceGenome:HGNC:21011
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene is a member of the metallocarboxypeptidase gene family. [provided by RefSeq, Jan 2011]
Expression
Biased expression in small intestine (RPKM 9.1) and thyroid (RPKM 0.3) See more
Orthologs
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Genomic context

See CPO in Genome Data Viewer
Location:
2q33.3
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (206939518..206969474)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (207280302..207451686)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (207804242..207834198)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17027 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17028 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:207634423-207635622 Neighboring gene malate dehydrogenase 1B Neighboring gene FAST kinase domains 2 Neighboring gene microRNA 3130-1 Neighboring gene microRNA 3130-2 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:207671457-207672284 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:207676275-207676890 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:207676891-207677508 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12270 Neighboring gene Sharpr-MPRA regulatory region 8398 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:207901421-207902246 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:207902247-207903074 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17029 Neighboring gene KLF transcription factor 7 Neighboring gene Sharpr-MPRA regulatory region 11101 Neighboring gene microRNA 2355 Neighboring gene NANOG hESC enhancer GRCh37_chr2:208007006-208007507 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:208013849-208014350 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12271 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:208028265-208028973 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:208028974-208029682 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17030 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr2:208030391-208031099 and GRCh37_chr2:208031100-208031807 Neighboring gene microRNA 7845

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
EBI GWAS Catalog

General gene information

Markers

Clone Names

  • MGC138281, MGC138283

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metallocarboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metallocarboxypeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
carboxypeptidase O
Names
metallocarboxypeptidase C
metallocarboxypeptidase O
NP_775100.1
XP_047299379.1
XP_054196562.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028078.1 RefSeqGene

    Range
    4965..34921
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_173077.3NP_775100.1  carboxypeptidase O precursor

    See identical proteins and their annotated locations for NP_775100.1

    Status: REVIEWED

    Source sequence(s)
    AC019052, AJ422118, BC112078
    Consensus CDS
    CCDS2372.1
    UniProtKB/Swiss-Prot
    Q2M277, Q7RTW7, Q8IVL8
    Related
    ENSP00000272852.2, ENST00000272852.4
    Conserved Domains (1) summary
    cd06247
    Location:47344
    M14_CPO; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase O subgroup

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    206939518..206969474
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047443423.1XP_047299379.1  carboxypeptidase O isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    207280302..207451686
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054340587.1XP_054196562.1  carboxypeptidase O isoform X2

    UniProtKB/Swiss-Prot
    Q2M277, Q7RTW7, Q8IVL8