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CPO carboxypeptidase O [ Homo sapiens (human) ]

Gene ID: 130749, updated on 8-Dec-2018

Summary

Official Symbol
CPOprovided by HGNC
Official Full Name
carboxypeptidase Oprovided by HGNC
Primary source
HGNC:HGNC:21011
See related
Ensembl:ENSG00000144410 MIM:609563
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene is a member of the metallocarboxypeptidase gene family. [provided by RefSeq, Jan 2011]
Expression
Biased expression in small intestine (RPKM 9.1) and thyroid (RPKM 0.3) See more
Orthologs

Genomic context

See CPO in Genome Data Viewer
Location:
2q33.3
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (206792477..206971064)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (207804278..207834198)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene malate dehydrogenase 1B Neighboring gene FAST kinase domains 2 Neighboring gene microRNA 3130-1 Neighboring gene microRNA 3130-2 Neighboring gene Kruppel like factor 7 Neighboring gene microRNA 2355 Neighboring gene microRNA 7845

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
NHGRI GWA Catalog

General gene information

Markers

Homology

Clone Names

  • MGC138281, MGC138283

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metallocarboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metallocarboxypeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
anchored component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
carboxypeptidase O
Names
metallocarboxypeptidase C
metallocarboxypeptidase O
NP_775100.1
XP_016858861.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028078.1 RefSeqGene

    Range
    5001..34921
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_173077.2NP_775100.1  carboxypeptidase O precursor

    See identical proteins and their annotated locations for NP_775100.1

    Status: REVIEWED

    Source sequence(s)
    AJ422118, BC112078
    Consensus CDS
    CCDS2372.1
    UniProtKB/Swiss-Prot
    Q8IVL8
    Related
    ENSP00000272852.2, ENST00000272852.3
    Conserved Domains (1) summary
    cd06247
    Location:47344
    M14_CPO; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase O subgroup

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    206792477..206971064
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017003372.2XP_016858861.1  carboxypeptidase O isoform X1

    UniProtKB/Swiss-Prot
    Q8IVL8
    Conserved Domains (1) summary
    cd06247
    Location:47344
    M14_CPO; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase O subgroup
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