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| Status |
Public on Nov 20, 2018 |
| Title |
Choroid Plexus Gene Expression in ApoE3 or ApoE4-Knockin Mouse Choroid Plexuses |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Laser capture microdissected choroid plexuses were obtained and expression arrays were generated to investigate gene expression in ApoE-Knockin choroid plexuses; the choroid plexus forms the cerebrospinal fluid, the cerebrospinal fliod barrier, functions as the major gateway for blood-born leukocytes to enter the brain in degenerative and inflammatory brain diseases, and the principal neuroimmune interface in the brain. We found lipid deposits in the aged choroid plexus of hyperlipidemic ApoE4-Knockin mice but none in normolipidemic ApoE4-Knockin or normolipidemic or hyperlipidemic ApoE3-Knockin control choroid plexuses. Here, we studied the functional impact and gene epressions these choroid plexuses.
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| Overall design |
6 replicates each of ApoE3 choroid plexuses or of ApoE4-Knockin mice either maintained under normal mouse chow or under high fat-diet (HFD) of aged (78 weeks old) mice were obtained and expression microarrays were generated
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| Contributor(s) |
Yin C, Habenicht A |
| Citation(s) |
30692699 |
| Submission date |
Aug 17, 2016 |
| Last update date |
Feb 19, 2019 |
| Contact name |
Andreas Johann Richard Habenicht |
| E-mail(s) |
Andreas.habenicht@med.uni-muenchen.de
|
| Organization name |
Ludwig Maximilians Universität München
|
| Department |
Medicine
|
| Lab |
Institute for Cardiovascular Disease Prevention
|
| Street address |
Pettenkoferstraße 9a
|
| City |
Munich |
| State/province |
Bavaria |
| ZIP/Postal code |
80336 |
| Country |
Germany |
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| Platforms (1) |
| GPL8321 |
[Mouse430A_2] Affymetrix Mouse Genome 430A 2.0 Array |
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| Samples (24)
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| Relations |
| BioProject |
PRJNA339308 |
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