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| Status |
Public on May 03, 2016 |
| Title |
DGAT1 regulates retinol-dependent regulatory T cell generation and mediates autoimmune encephalomyelitis |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
This file contains gene microarray data from FACS purified mouse memory phenotype CD4+ T cells (CD44hiCD45RBloCD25-), which were isolated from lymph node and spinal cord tissues of mice with experimental autoimmune encephalomyelitis (EAE), a widely studied model of human multiple sclerosis (MS). Memory phenotype CD4+ T cells infiltrating the CNS during EAE expressed high levels of mRNA for Dgat1 encoding diacylglycerol-O-acyltransferase-1 (DGAT1). We studied the biology of DGAT1 in EAE models and in assays of T cell differentiation and function.
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| Overall design |
We analyzed transcript expression data from memory phenotype CD4+ T cells derived from draining lymph nodes (n=3) and spinal cords (n=3) of mice with acute symptomatic EAE .
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| Contributor(s) |
Graham KL |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
May 02, 2016 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Kareem Graham |
| E-mail(s) |
kareemlgraham@gmail.com
|
| Organization name |
Emory University
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| Department |
Physiology
|
| Street address |
615 Michael Street, Room 601
|
| City |
Atlanta |
| State/province |
GA |
| ZIP/Postal code |
30322 |
| Country |
USA |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA320220 |
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