|
| Status |
Public on Feb 24, 2019 |
| Title |
Altered cell signaling in the absence of Dynamin function: a transcriptomic approach from yeast to humans (human) |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Dynamins are large multidomain GTPases involved in membrane scission. We have investigated the transcriptional consequences of deleting DNM2 by siRNA in HeLa cells. Interestingly, DNM2 depletion causes strong transcriptional defects.
Data suggest that DNM2 playes an essential regulatory role connecting several membrane-related processes including endocytosis, lipid homeostasis and different signal transduction pathways.
|
| |
|
| Overall design |
HeLa cells were transfected with control siRNA (siControl) or siRNA against DNM2 (siDNM2) and samples were taken after 24 h or 72 h. Three independent samples were taken from each condition.
|
| |
|
| Contributor(s) |
Dominguez-Sanchez MS, Alfonso-Perez T, Morillo-Huesca M, Perez-Alegre M, Andujar E, Bachetti V, Garcia-Dominguez M, Reyes C |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Feb 24, 2016 |
| Last update date |
Feb 25, 2019 |
| Contact name |
Eloisa Andujar |
| E-mail(s) |
eloisa.andujar@cabimer.es
|
| Phone |
954467828
|
| Organization name |
CABIMER-CSIC
|
| Department |
GENOMICS UNIT
|
| Street address |
Avda Americo vespucio s/n
|
| City |
Sevilla |
| State/province |
Sevilla |
| ZIP/Postal code |
41092 |
| Country |
Spain |
| |
|
| Platforms (1) |
| GPL6244 |
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version] |
|
| Samples (12)
|
|
| Relations |
| BioProject |
PRJNA313064 |
Less...
More...