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| Status |
Public on Sep 01, 2012 |
| Title |
Deciphering Gene Expression Program of MAP3K1 in Mouse Eyelid Morphogenesis |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Embryonic eyelid closure is a critical step of mammalian ocular surface development involving the forward movement and ultimate fusion of the upper and lower eyelids. Although its underlying mechanism of action is not fully understood, a functional mitogen-activated protein kinase kinase kinase 1 (MAP3K1) is essentially required for eyelid closure.
We used microarray to characterize the central role that MAP3K1 plays in embryonic eyelid closure.
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| Overall design |
We used Laser Capture Microdissection (LCM) to obtain highly enriched eyelid leading edge and inner eyelid cells from E15.5 wild type and MAP3K1-deficient fetuses and analyze genome-wide expression profiles.
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| Contributor(s) |
Jin C, Chen J, Meng Q, Carreira V, Tam N, Geh E, Karyala S, Ho S, Zhou X, Medvedovic M, Xia Y |
| Citation(s) |
23201579, 24498290 |
| Submission date |
Jul 10, 2012 |
| Last update date |
Oct 23, 2019 |
| Contact name |
Mario Medvedovic |
| Organization name |
University of Cincinnati
|
| Department |
Department of Environmental Health
|
| Lab |
Laboratory for Statistical Genomics and Systems Biology
|
| Street address |
3223 Eden Av. ML 56
|
| City |
Cincinnati |
| State/province |
OH |
| ZIP/Postal code |
45267-0056 |
| Country |
USA |
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| Platforms (1) |
| GPL13712 |
[MoEx-1_0-st] Affymetrix Mouse Exon 1.0 ST Array [Alternative CDF: BrainArray version 14: MoEx10stv1_Mm_ENTREZG] |
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| Samples (11)
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| Relations |
| BioProject |
PRJNA170306 |
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