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| Status |
Public on Mar 21, 2024 |
| Title |
A complex pattern of gene expression in tissue affected by viperid snake envenoming: the emerging role of autophagy-related genes |
| Platform organism |
Homo sapiens |
| Sample organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Cellular and inflammatory events were evaluated in mouse muscle after snake venoms Daboia russelii and Bothrops asper injection over time. A murine model of muscle necrosis based on venom injection was used to investigate up to 800 genes involved in fibrosis diseases and tissue regeneration using the multiplex RNA panel Fibrosis V2 from NanoString technology.
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| Overall design |
In this study we have used the Nanostring technology to evaluate the patterns of gene expression in mouse skeletal muscle 1 hr, 6 hr and 24 hr after injection of the venoms of Bothrops asper and Daboia russelii, two medically relevant species in Latin America and Asia, respectively, with somewhat different clinical manifestations. We focused our analysis on genes related to extracellular matrix (ECM) metabolism, immune system, programmed cell death, and autophagy.
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| Contributor(s) |
de Oliveira A, Rucavado A, Escalante T, Gutiérrez JM, Fox JW |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Nov 19, 2023 |
| Last update date |
Mar 21, 2024 |
| Contact name |
Ana Karina de Olliiveirra |
| E-mail(s) |
ankaoliv@gmail.com
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| Phone |
434-924-1753
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| Organization name |
UVA
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| Department |
Department of Pathology
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| Lab |
Spatial Biology Core
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| Street address |
1340 Jefferson Park Avenue
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| City |
Charlottesville |
| State/province |
VA |
| ZIP/Postal code |
22908 |
| Country |
USA |
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| Platforms (1) |
| GPL31258 |
NanoString nCounter human fibrosis panel [NS_HS_FIBROSIS_V2.0 or V2.1] |
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| Samples (20)
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| Relations |
| BioProject |
PRJNA1042831 |
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