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| Status |
Public on Jan 17, 2020 |
| Title |
Characterization of Sheep Milk Extracellular Vesicle-miRNA by Sequencing and Comparison with Cow milk |
| Organisms |
Bos taurus; Ovis aries |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Milk can mediate maternal-neonatal signal transmission by the bioactive component-extracellular vesicles (EVs), which select specific types of miRNA to encapsulate. The miRNA profiling of sheep milk EVs was characterized by sequencing and compared with that of cow milk. Sheep milk EVs contained various small RNAs, including tRNA, Cis-regulatory element, rRNA, snRNA, other Rfam RNA, and miRNA, which held about 36% of all the small RNAs. Totally 84 types of miRNAs were annotated with Ovis aries by miRBase (version 22.0) in sheep milk EVs, with 75 shared types of miRNAs in all samples. Fourteen sheep milk EV-miRNAs in the top 20, occupying 98% of the total expression, were immune-related.
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| Overall design |
The miRNA profiling of sheep milk EVs was characterized by sequencing and compared with that of cow milk in our prior study.
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| Contributor(s) |
Quan S, Nan X |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Jan 16, 2020 |
| Last update date |
Jan 17, 2020 |
| Contact name |
suyu quan |
| E-mail(s) |
quansuyu@163.com, 82101179308@caas.cn
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| Organization name |
Institute of Animal Sciences, Chinese Academy of Agricultural Sciences
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| Street address |
Yuanmingyuan West Road No.2, Haidian Distric
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| City |
Beijing |
| ZIP/Postal code |
100193 |
| Country |
China |
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| Platforms (2) |
| GPL15670 |
Illumina HiSeq 2000 (Ovis aries) |
| GPL15749 |
Illumina HiSeq 2000 (Bos taurus) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA601662 |
| SRA |
SRP242194 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE143779_1_all_miRNA_counts_Cow.txt.gz |
4.5 Kb |
(ftp)(http) |
TXT |
| GSE143779_1_all_miRNA_counts_Sheep.txt.gz |
10.7 Kb |
(ftp)(http) |
TXT |
| GSE143779_2_all_miRNA_TPM_Cow.txt.gz |
8.7 Kb |
(ftp)(http) |
TXT |
| GSE143779_2_all_miRNA_TPM_Sheep.txt.gz |
17.2 Kb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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