|
| Status |
Public on Jul 04, 2020 |
| Title |
RNA expression profile comparison of HFKs expressing E6/E7 from beta-3 HPVs (49, 75, 76, 115) and from HR alpha HPV16 and beta-2 HPV38 |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Comparative analysis of RNA expression profiles of keratinocytes expressing E6/E7 from the different beta-3, with the RNA profiles of HPV16 and HPV38 E6/E7 HFKs reveals that HPV115 is the more divergent from the HR-mucosal type. Moreover beta-3 HPV 49, 75 and 76 E6/E7 HFKs show altered expression of genes involved in cell cycle regulation and DNA damage response which are also deregulated by expression of E6/E7 of HPV16.
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| |
|
| Overall design |
Total RNA obtained from Human Foreskin Keratinocytes (HFKs) expressing E6/E7 from 6 different HPV types (49, 75, 76, 115, 16, 38) compared to 2 controls (HFK and empty vector).
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| |
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| Contributor(s) |
Accardi-Gheit RM, Tommasino M, Minoni L, Le Calvez-Kelm F |
| Citation(s) |
32669468 |
| Submission date |
Jun 30, 2017 |
| Last update date |
Jul 25, 2021 |
| Contact name |
Alexis Robitaille |
| E-mail(s) |
robitaillea@students.iarc.fr
|
| Organization name |
International Agency for Research on Cancer (IARC)
|
| Department |
Section of Infections
|
| Lab |
Infections and Cancer Biology Group
|
| Street address |
150 Cours Albert Thomas
|
| City |
LYON |
| State/province |
Rhône-Alpes |
| ZIP/Postal code |
69008 |
| Country |
France |
| |
|
| Platforms (1) |
| GPL10558 |
Illumina HumanHT-12 V4.0 expression beadchip |
|
| Samples (20)
|
|
| Relations |
| BioProject |
PRJNA392656 |
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