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    nAChRa7 nicotinic acetylcholine receptor alpha7 subunit [ Apis mellifera (honey bee) ]

    Gene ID: 406148, updated on 20-Nov-2023

    Summary

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    Gene symbol
    nAChRa7
    Gene description
    nicotinic acetylcholine receptor alpha7 subunit
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Apis mellifera
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea; Anthophila; Apidae; Apis
    Also known as
    GB19257; GB53053; Apisa7-1
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    Genomic context

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    Location:
    chromosome: LG14
    Exon count:
    13
    Annotation release Status Assembly LG Location
    104 current Amel_HAv3.1 (GCF_003254395.2) LG14 NC_037651.1 (1798027..2042183)
    103 previous assembly Amel_4.5 (GCF_000002195.4) LG14 NC_007083.3 (1149292..1304393)

    Linkage Group LG14 - NC_037651.1Genomic Context describing neighboring genes Neighboring gene B-cell receptor-associated protein 31 Neighboring gene uncharacterized LOC113219219 Neighboring gene NADH dehydrogenase (ubiquinone) B16.6 subunit Neighboring gene nicotinic acetylcholine receptor beta1 Neighboring gene furin-like protease 1 Neighboring gene multiple inositol polyphosphate phosphatase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Apisalpha2, Apisalpha7-1 and Apisalpha7-2: three new neuronal nicotinic acetylcholine receptor alpha-subunits in the honeybee brain. Thany SH, et al. Gene, 2005 Jan 3. PMID 15656979
    2. Expression patterns of nicotinic subunits α2, α7, α8, and β1 affect the kinetics and pharmacology of ACh-induced currents in adult bee olfactory neuropiles. Dupuis JP, et al. J Neurophysiol, 2011 Oct. PMID 21734106
    3. Insights into social insects from the genome of the honeybee Apis mellifera. Honeybee Genome Sequencing Consortium. Nature, 2006 Oct 26. PMID 17073008, Free PMC Article
    4. ProtoBee: hierarchical classification and annotation of the honey bee proteome. Kaplan N, et al. Genome Res, 2006 Nov. PMID 17065614, Free PMC Article
    5. Finding the missing honey bee genes: lessons learned from a genome upgrade. Elsik CG, et al. BMC Genomics, 2014 Jan 30. PMID 24479613, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Comparison of Kenyon cells with adult antennal lobe cells revealed the supplementary presence of subunit alpha7, which may explain the kinetic & pharmacological differences in ACh-induced currents from these 2 cell types.
      Title: Expression patterns of nicotinic subunits α2, α7, α8, and β1 affect the kinetics and pharmacology of ACh-induced currents in adult bee olfactory neuropiles.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables acetylcholine-gated monoatomic cation-selective channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nervous system process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nicotinic acetylcholine receptor alpha7 subunit
    Names
    nAChRalpha7
    neuronal nicotinic acetylcholine receptor alpha7-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011621.1 → NP_001011621.1  nicotinic acetylcholine receptor alpha7 subunit precursor

      See identical proteins and their annotated locations for NP_001011621.1

      Status: PROVISIONAL

      Source sequence(s)
      AY500239
      UniProtKB/TrEMBL
      A0A0H3V199, A0A7M6UUB9, A0A8B6WZ14, A0A8U0WQ95, Q6RFT1
      Conserved Domains (3) summary
      TIGR00860
      Location:4 → 549
      LIC; Cation transporter family protein
      pfam02931
      Location:24 → 231
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:238 → 544
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    RefSeqs of Annotated Genomes: Apis mellifera Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Amel_HAv3.1 Primary Assembly

    Genomic

    1. NC_037651.1 Reference Amel_HAv3.1 Primary Assembly

      Range
      1798027..2042183
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_026444870.1 → XP_026300655.1  nicotinic acetylcholine receptor alpha7 subunit isoform X1

      UniProtKB/TrEMBL
      A0A0H3V199, A0A7M7MTA7, A0A8B8H9F3
      Conserved Domains (2) summary
      TIGR00860
      Location:4 → 560
      LIC; Cation transporter family protein
      cd18997
      Location:49 → 230
      LGIC_ECD_nAChR; extracellular domain of nicotinic acetylcholine receptor

    2. XM_026444873.1 → XP_026300658.1  nicotinic acetylcholine receptor alpha7 subunit isoform X3

      UniProtKB/TrEMBL
      A0A0H3V199, A0A7M7MTP0, A0A8B8HAH5
      Conserved Domains (2) summary
      TIGR00860
      Location:1 → 476
      LIC; Cation transporter family protein
      cd18997
      Location:1 → 146
      LGIC_ECD_nAChR; extracellular domain of nicotinic acetylcholine receptor

    3. XM_026444871.1 → XP_026300656.1  nicotinic acetylcholine receptor alpha7 subunit isoform X2

      UniProtKB/TrEMBL
      A0A0H3V199, A0A7M7MTB2, A0A8B8H9F4
      Conserved Domains (1) summary
      cl27321
      Location:14 → 498
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Molecular Biology Databases
    Research Materials