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    MLH3 MUTL protein homolog 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829704, updated on 7-Sep-2023

    Summary

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    Gene symbol
    MLH3
    Gene description
    MUTL protein homolog 3
    Primary source
    Araport:AT4G35520
    Locus tag
    AT4G35520
    See related
    TAIR:AT4G35520
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATMLH3; F8D20.30; F8D20_30; MUTL protein homolog 3
    Summary
    DNA mismatch repair protein similar to MutL. Required for normal levels of meiotic crossovers
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    Genomic context

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    See MLH3 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    24
    Sequence:
    Chromosome: 4; NC_003075.7 (16865304..16871527)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Protein kinase superfamily protein Neighboring gene PHD finger-like protein Neighboring gene uncharacterized protein Neighboring gene phosphatidylinositolglycan-like protein Neighboring gene ncRNA Neighboring gene POLLEN-EXPRESSED TRANSCRIPTION FACTOR 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Reduced meiotic crossovers and delayed prophase I progression in AtMLH3-deficient Arabidopsis. Jackson N, et al. EMBO J, 2006 Mar 22. PMID 16467846, Free PMC Article
    2. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    NM_001342354.1
    NM_001342358.1
    NM_001342359.1
    NM_001342360.1
    NM_119717.7

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent DNA damage sensor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mismatched DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mismatch repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mismatch repair complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    MUTL protein homolog 3
    NP_001320143.1
    • MUTL protein homolog 3 (MLH3); FUNCTIONS IN: mismatched DNA binding, ATP binding; INVOLVED IN: mismatch repair, reciprocal meiotic recombination; LOCATED IN: chromosome; EXPRESSED IN: inflorescence; CONTAINS InterPro DOMAIN/s: DNA mismatch repair protein, N-terminal (InterPro:IPR014763), MutL, C-terminal, dimerisation (InterPro:IPR014790), DNA mismatch repair protein (InterPro:IPR002099), DNA mismatch repair, conserved site (InterPro:IPR014762), ATPase-like, ATP-binding domain (InterPro:IPR003594); BEST Arabidopsis thaliana protein match is: DNA mismatch repair protein, putative (TAIR:AT4G02460.1); Has 8909 Blast hits to 6784 proteins in 2360 species: Archae - 138; Bacteria - 6148; Metazoa - 581; Fungi - 681; Plants - 158; Viruses - 0; Other Eukaryotes - 1203 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      16865304..16871527
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001342355.1 → NP_001328252.1  MUTL protein homolog 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178V761, A0A1P8B445

    2. NM_001342356.1 → NP_001328253.1  MUTL protein homolog 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178V7B3, A0A1P8B434

    3. NM_001342357.1 → NP_001328256.1  MUTL protein homolog 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B439, A0A654FVR9

    4. NM_001342354.1 → NP_001320143.1  MUTL protein homolog 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4JN26, O81785
      UniProtKB/TrEMBL
      A0A654FVR9

    5. NM_001342358.1 → NP_001328251.1  MUTL protein homolog 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B465, A0A654FVR9

    6. NM_001342359.1 → NP_001328254.1  MUTL protein homolog 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B429, A0A654FVR9

    7. NM_119717.7 → NP_195277.6  MUTL protein homolog 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B406

    8. NM_001342360.1 → NP_001328255.1  MUTL protein homolog 3 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B459
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4JN26.2

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