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    thrB homoserine kinase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947498, updated on 19-Sep-2024

    Summary

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    Official Symbol
    thrB
    Official Full Name
    homoserine kinase
    Primary source
    ECOCYC:EG10999
    Locus tag
    b0003
    See related
    ASAP:ABE-0000010
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0003
    Summary
    Homoserine kinase (ThrB) catalyzes the conversion of homoserine to O-phospho-L-homoserine en route to generating threonine. [More information is available at EcoCyc: EG10999].
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    Genomic context

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    Sequence:
    NC_000913.3 (2801..3733)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene thr operon leader peptide Neighboring gene fused aspartate kinase/homoserine dehydrogenase 1 Neighboring gene threonine synthase Neighboring gene DUF2502 domain-containing protein YaaX

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional group characterization of homoserine kinase from Escherichia coli. Huo X, et al. Arch Biochem Biophys, 1996 Jun 15. PMID 8660667
    2. Homoserine kinase of Escherichia coli: kinetic mechanism and inhibition by L-aspartate semialdehyde. Shames SL, et al. Arch Biochem Biophys, 1984 Dec. PMID 6097184
    3. Homoserine kinase from Escherichia coli K-12: properties, inhibition by L-threonine, and regulation of biosynthesis. Théze J, et al. J Bacteriol, 1974 May. PMID 4364023, Free PMC Article
    4. Evidence for an internal promoter in the Escherichia coli threonine operon. Saint Girons I, et al. J Bacteriol, 1985 Jan. PMID 3918011, Free PMC Article
    5. Homoserine kinase from Escherichia coli K12. Burr B, et al. Eur J Biochem, 1976 Mar 1. PMID 177283

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables homoserine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables homoserine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in threonine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within threonine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in threonine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    homoserine kinase
    NP_414544.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2801..3733
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414544.1 homoserine kinase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414544.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      S4VDV0
      Conserved Domains (1) summary
      TIGR00191
      Location:2 → 308
      thrB; homoserine kinase
    Nucleotide Protein
    Heading Accession and Version

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