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    wcaD colanic acid polymerase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946550, updated on 2-May-2024

    Summary

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    Gene symbol
    wcaD
    Gene description
    colanic acid polymerase
    Primary source
    ASAP:ABE-0006809
    Locus tag
    b2056
    See related
    ECOCYC:G7101
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2050
    Summary
    The ortholog of WcaD in Escherichia coli O157:H7 is involved in colanic acid synthesis . [More information is available at EcoCyc: G7101].
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    Genomic context

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    Sequence:
    NC_000913.3 (2129661..2130878, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene colanic acid biosynthesis acetyltransferase WcaF Neighboring gene GDP-Fuc:2/3-O-Ac-alpha-L-Fuc-(1->3)-alpha-D-Glc-PP-Und alpha-(1,4)-fucosyltransferase Neighboring gene colanic acid biosynthesis galactosyltransferase WcaC Neighboring gene colanic acid biosynthesis acetyltransferase WcaB Neighboring gene UDP-glucuronate:2-O-Ac-beta-D-Gal-(1->3)-alpha-L-Fuc-(1->4)-2/3-O-Ac-alpha-L-Fuc-(1->3)-beta-D-Glc-PP-Und beta-(1,3)-glucuronosyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Insertion mutagenesis of wca reduces acid and heat tolerance of enterohemorrhagic Escherichia coli O157:H7. Mao Y, et al. J Bacteriol, 2001 Jun. PMID 11371548, Free PMC Article
    2. Biosynthesis and assembly of capsular polysaccharides in Escherichia coli. Whitfield C. Annu Rev Biochem, 2006. PMID 16756484
    3. Development of a biofilm production-deficient Escherichia coli strain as a host for biotechnological applications. Sung BH, et al. Appl Environ Microbiol, 2006 May. PMID 16672475, Free PMC Article
    4. Temporal gene-expression in Escherichia coli K-12 biofilms. Domka J, et al. Environ Microbiol, 2007 Feb. PMID 17222132
    5. Organization of the Escherichia coli K-12 gene cluster responsible for production of the extracellular polysaccharide colanic acid. Stevenson G, et al. J Bacteriol, 1996 Aug. PMID 8759852, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Gene Ontology Provided by EcoCyc

    Process Evidence Code Pubs
    acts_upstream_of_or_within colanic acid metabolic process IGC
    Inferred from Genomic Context
    more info
    		 PubMed 
    involved_in lipopolysaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in slime layer polysaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    colanic acid polymerase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2129661..2130878 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416560.1 colanic acid polymerase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416560.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A7L5V5R0, G1UG13
      Conserved Domains (1) summary
      TIGR04010
      Location:1 → 404
      WcaD; putative colanic acid polymerase WcaD
    Nucleotide Protein
    Heading Accession and Version

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