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    dadA [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945752, updated on 11-Sep-2024

    Summary

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    Official Symbol
    dadA
    Primary source
    ECOCYC:EG11407
    Locus tag
    b1189
    See related
    ASAP:ABE-0003995
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    dadR; ECK1177
    Summary
    dadR is the name that was assigned to cis-acting regulatory mutations in the dadA promoter region. [More information is available at EcoGene: EG11407]. The enzyme is composed of two non-identical subunits, the gene dadA codes for the smaller unit and an unidentified gene for the larger. [More information is available at EcoCyc: EG11407].
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    Genomic context

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    Sequence:
    NC_000913.3 (1237571..1238869)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional dual regulator FadR Neighboring gene PF04293 family protein YcgB Neighboring gene alanine racemase 2 Neighboring gene protein YmgM Neighboring gene putative K(+):H(+) antiporter

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic studies of D-alanine-dehydrogenase-less mutants of Escherichia coli K12. Franklin FC, et al. Genet Res, 1981 Oct. PMID 7035293
    2. Solubilisation of D-amino acid dehydrogenase of Escherichia coli K12 and its re-binding to envelope preparations. Jones H, et al. Biochimie, 1983 Mar. PMID 6133564
    3. Effects of solubilisation on some properties of the membrane-bound respiratory enzyme D-amino acid dehydrogenase of Escherichia coli. Jones H, et al. FEBS Lett, 1983 Jan 24. PMID 6131836
    4. Regulation of expression of the dadA gene encoding D-amino acid dehydrogenase in Escherichia coli: analysis of dadA-lac fusions and direction of dadA transcription. Wild J, et al. Mol Gen Genet, 1982. PMID 6126797
    5. Purification and properties of D-amino acid dehydrogenase, an inducible membrane-bound iron-sulfur flavoenzyme from Escherichia coli B. Olsiewski PJ, et al. J Biol Chem, 1980 May 25. PMID 6102989

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables D-amino-acid dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables D-amino-acid dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables D-amino-acid dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in D-alanine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in D-alanine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in D-alanine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in D-amino acid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-alanine oxidation to pyruvate via D-alanine IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    D-amino acid dehydrogenase
    NP_415707.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1237571..1238869
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      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415707.1 D-amino acid dehydrogenase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415707.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A7A6XQY3
      Conserved Domains (1) summary
      PRK00711
      Location:1 → 415
      PRK00711; D-amino acid dehydrogenase
    Nucleotide Protein
    Heading Accession and Version

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