FOLT1 folate transporter 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Gene symbol: FOLT1
Gene description: folate transporter 1
Primary source: Araport:AT5G66380
Locus tag: AT5G66380
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATFOLT1; folate transporter 1; K1F13.3; K1F13_3
Summary: Encodes a folate transporter that is located in the chloroplast envelope and is able to mediate exogenous folate uptake when expressed in E. coli. However, this is not the sole folate transporter for chloroplasts as null mutants of this gene have no discernible phenotype when grown under folate-sufficient conditions and contained wild-type levels of folates in leaves.
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Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Arabidopsis non-host resistance PSS30 gene enhances broad-spectrum disease resistance in the soybean cultivar Williams 82.
Title: Arabidopsis non-host resistance PSS30 gene enhances broad-spectrum disease resistance in the soybean cultivar Williams 82.
AtFOLT1, an Arabidopsis homolog of the mammalian mitochondrial folate transporter, mediates folate import into chloroplasts
Title: Folate metabolism in plants: an Arabidopsis homolog of the mammalian mitochondrial folate transporter mediates folate import into chloroplasts.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

NM_126036.4

Function	Evidence Code	Pubs
enables folic acid transmembrane transporter activity	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within folic acid transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nucleotide transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chloroplast	IDA Inferred from Direct Assay more info	PubMed
located_in chloroplast envelope	IDA Inferred from Direct Assay more info	PubMed
NOT located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISM Inferred from Sequence Model more info

NP_569032.1

folate transporter 1 (FOLT1); CONTAINS InterPro DOMAIN/s: Mitochondrial substrate carrier (InterPro:IPR001993), Mitochondrial substrate/solute carrier (InterPro:IPR018108), Adenine nucleotide translocator 1 (InterPro:IPR002113); BEST Arabidopsis thaliana protein match is: NAD+ transporter 2 (TAIR:AT1G25380.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).