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    APL1 ADP glucose pyrophosphorylase large subunit 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 832042, updated on 7-Sep-2023

    Summary

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    Gene symbol
    APL1
    Gene description
    ADP glucose pyrophosphorylase large subunit 1
    Primary source
    Araport:AT5G19220
    Locus tag
    AT5G19220
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ADG2; ADP GLUCOSE PYROPHOSPHORYLASE 2; ADP glucose pyrophosphorylase large subunit 1; ADPG PYROPHOSPHORYLASE; T24G5.120; T24G5_120
    Summary
    Encodes the large subunit of ADP-glucose pyrophosphorylase which catalyzes the first, rate limiting step in starch biosynthesis. The large subunit plays a regulatory role whereas the small subunit (ApS) is the catalytic isoform. Four isoforms (ApL1-4) have been identified. ApL1 is the major large subunit isoform present in leaves. Mutational analysis of APS1 suggests that APL1 and APL2 can compensate for loss of APS1 catalytic activity,suggesting both have catalytic as well as regulatory functions.
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    Genomic context

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    Location:
    chromosome: 5
    Exon count:
    15
    Sequence:
    Chromosome: 5; NC_003076.8 (6463824..6466831, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene NAD(P)-binding Rossmann-fold superfamily protein Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein Neighboring gene ncRNA Neighboring gene Glycoprotein membrane precursor GPI-anchored Neighboring gene Glycoprotein membrane precursor GPI-anchored

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulatory properties of ADP glucose pyrophosphorylase are required for adjustment of leaf starch synthesis in different photoperiods. Mugford ST, et al. Plant Physiol, 2014 Dec. PMID 25293961, Free PMC Article
    2. Two Arabidopsis ADP-glucose pyrophosphorylase large subunits (APL1 and APL2) are catalytic. Ventriglia T, et al. Plant Physiol, 2008 Sep. PMID 18614708, Free PMC Article
    3. Redox Conformation-Specific Protein-Protein Interactions of the 2-Cysteine Peroxiredoxin in Arabidopsis. Liebthal M, et al. Antioxidants (Basel), 2020 Jun 11. PMID 32545358, Free PMC Article
    4. The oligomeric stromal proteome of Arabidopsis thaliana chloroplasts. Peltier JB, et al. Mol Cell Proteomics, 2006 Jan. PMID 16207701
    5. Quantitative proteomics of a chloroplast SRP54 sorting mutant and its genetic interactions with CLPC1 in Arabidopsis. Rutschow H, et al. Plant Physiol, 2008 Sep. PMID 18633119, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. may contribute to ADP-glucose synthesis
      Title: Two Arabidopsis ADP-glucose pyrophosphorylase large subunits (APL1 and APL2) are catalytic.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_121927.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables glucose-1-phosphate adenylyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glycogen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in starch biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast envelope HDA PubMed 
    located_in chloroplast stroma HDA PubMed 

    General protein information

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    Preferred Names
    ADP glucose pyrophosphorylase large subunit 1
    NP_197423.1
    • ADP glucose pyrophosphorylase large subunit 1 (APL1); FUNCTIONS IN: glucose-1-phosphate adenylyltransferase activity; INVOLVED IN: cellulose biosynthetic process, biosynthetic process, glycogen biosynthetic process; LOCATED IN: chloroplast, chloroplast stroma, chloroplast envelope; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Glucose-1-phosphate adenylyltransferase (InterPro:IPR011831), ADP-glucose pyrophosphorylase, conserved site (InterPro:IPR005836), Nucleotidyl transferase (InterPro:IPR005835); BEST Arabidopsis thaliana protein match is: ADPGLC-PPase large subunit (TAIR:AT1G27680.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      6463824..6466831 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_121927.3 → NP_197423.1  ADP glucose pyrophosphorylase large subunit 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_197423.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04929, P55229, Q9SXS1
      UniProtKB/TrEMBL
      A0A178UL90, A0A5S9Y5H2
      Conserved Domains (3) summary
      cd04651
      Location:390 → 516
      LbH_G1P_AT_C; Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and ...
      PLN02241
      Location:87 → 522
      PLN02241; glucose-1-phosphate adenylyltransferase
      pfam00483
      Location:93 → 367
      NTP_transferase; Nucleotidyl transferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P55229.3

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