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    ROPGEF5 ROP guanine nucleotide exchange factor 5 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 830479, updated on 15-Feb-2024

    Summary

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    Gene symbol
    ROPGEF5
    Gene description
    ROP guanine nucleotide exchange factor 5
    Primary source
    Araport:AT5G05940
    Locus tag
    AT5G05940
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATROPGEF5; K18J17.10; K18J17_10; ROP (rho of plants) guanine nucleotide exchange factor 5; ROP guanine nucleotide exchange factor 5; ROP GUANINE NUCLEOTIDE EXCHANGE FACTOR 5
    Summary
    Encodes a member of KPP-like gene family, homolog of KPP (kinase partner protein) gene in tomato. Also a member of the RopGEF (guanine nucleotide exchange factor) family, containing the novel PRONE domain (plant-specific Rop nucleotide exchanger), which is exclusively active towards members of the Rop subfamily.
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    Genomic context

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    Location:
    chromosome: 5
    Exon count:
    6
    Sequence:
    Chromosome: 5; NC_003076.8 (1785845..1788600)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene deoxyhypusine synthase Neighboring gene guanylyl cyclase 1 Neighboring gene tRNA-Asp Neighboring gene maternal effect embryo arrest 60 Neighboring gene Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Members of a novel class of Arabidopsis Rho guanine nucleotide exchange factors control Rho GTPase-dependent polar growth. Gu Y, et al. Plant Cell, 2006 Feb. PMID 16415208, Free PMC Article
    2. A new family of RhoGEFs activates the Rop molecular switch in plants. Berken A, et al. Nature, 2005 Aug 25. PMID 15980860
    3. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714
    4. Multi-omics network-based functional annotation of unknown Arabidopsis genes. Depuydt T, et al. Plant J, 2021 Nov. PMID 34562334

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    NM_120676.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    ROP guanine nucleotide exchange factor 5
    NP_196213.2
    • ROP guanine nucleotide exchange factor 5 (ROPGEF5); CONTAINS InterPro DOMAIN/s: Rop nucleotide exchanger, PRONE (InterPro:IPR005512); BEST Arabidopsis thaliana protein match is: RHO guanyl-nucleotide exchange factor 7 (TAIR:AT5G02010.1); Has 303 Blast hits to 301 proteins in 15 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 303; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      1785845..1788600
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      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001342847.1 → NP_001332731.1  ROP guanine nucleotide exchange factor 5 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1R7T3I0

    2. NM_120676.3 → NP_196213.2  ROP guanine nucleotide exchange factor 5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_196213.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4K295, Q9FI92
      UniProtKB/TrEMBL
      A0A5S9Y2L3
      Conserved Domains (1) summary
      pfam03759
      Location:101 → 472
      PRONE; PRONE (Plant-specific Rop nucleotide exchanger)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4K295.1

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