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    PAB2 poly(A) binding protein 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829557, updated on 15-Oct-2023

    Summary

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    Gene symbol
    PAB2
    Gene description
    poly(A) binding protein 2
    Primary source
    Araport:AT4G34110
    Locus tag
    AT4G34110
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS POLY(A) BINDING 2; ATPAB2; F28A23.130; F28A23_130; PABP2; poly(A) binding protein 2; POLY(A) BINDING PROTEIN 2; POLY(A)-BINDING PROTEIN 2
    Summary
    Putative poly-A binding protein. Member of a gene family .Expressed in stele and root meristem and post-fertilization ovules.Member of the class II family of PABP proteins.
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    Genomic context

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    Location:
    chromosome: 4
    Exon count:
    9
    Sequence:
    Chromosome: 4; NC_003075.7 (16336291..16340314)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene RING/U-box superfamily protein Neighboring gene miscRNA Neighboring gene Cystathionine beta-synthase (CBS) family protein Neighboring gene ncRNA Neighboring gene UDP-glucosyl transferase 73B3 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The poly(A) binding protein is internalized in virus-induced vesicles or redistributed to the nucleolus during turnip mosaic virus infection. Beauchemin C, et al. J Virol, 2007 Oct. PMID 17670821, Free PMC Article
    2. Conserved expression of Arabidopsis thaliana poly (A) binding protein 2 (PAB2) in distinct vegetative and reproductive tissues. Palanivelu R, et al. Plant J, 2000 May. PMID 10849338
    3. Arabidopsis thaliana poly (A) binding protein 2 (PAB2) functions in yeast translational and mRNA decay processes. Palanivelu R, et al. Plant J, 2000 May. PMID 10849337
    4. Molecular characterization of PAB2, a member of the multigene family coding for poly(A)-binding proteins in Arabidopsis thaliana. Hilson P, et al. Plant Physiol, 1993 Oct. PMID 8029336, Free PMC Article
    5. Uridylation and PABP Cooperate to Repair mRNA Deadenylated Ends in Arabidopsis. Zuber H, et al. Cell Rep, 2016 Mar 22. PMID 26972004

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Poly(A) Binding Protein binds to uridylated oligo(A) tails and determines the length of U-extensions added by URT1.
      Title: Uridylation and PABP Cooperate to Repair mRNA Deadenylated Ends in Arabidopsis.
    2. Thus, Hsc70-3 and PABP2 are potentially integral components of the replicase complex and could have important roles to play in the regulation of potyviral RdRp functions.
      Title: Heat shock 70 protein interaction with Turnip mosaic virus RNA-dependent RNA polymerase within virus-induced membrane vesicles.
    3. PAB2 was partially retargeted to the nucleolus in the presence of TuMV VPg-Pro. In addition, the membrane association of PAB2 during TuMV infection resulted from the internalization of the host protein in 6K-VPg-Pro-induced vesicles.
      Title: The poly(A) binding protein is internalized in virus-induced vesicles or redistributed to the nucleolus during turnip mosaic virus infection.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_119572.7

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables mRNA binding HDA PubMed 
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables translation initiation factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA stabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of nuclear-transcribed mRNA poly(A) tail shortening IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of translational initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within translational initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    poly(A) binding protein 2
    NP_195137.5
    • poly(A) binding protein 2 (PAB2); FUNCTIONS IN: RNA binding, translation initiation factor activity; INVOLVED IN: response to salt stress, translational initiation; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 17 growth stages; CONTAINS InterPro DOMAIN/s: Polyadenylate-binding protein/Hyperplastic disc protein (InterPro:IPR002004), RNA recognition motif, RNP-1 (InterPro:IPR000504), Polyadenylate binding protein, human types 1, 2, 3, 4 (InterPro:IPR006515), Paraneoplastic encephalomyelitis antigen (InterPro:IPR002343), Nucleotide-binding, alpha-beta plait (InterPro:IPR012677); BEST Arabidopsis thaliana protein match is: poly(A) binding protein 8 (TAIR:AT1G49760.2); Has 987994 Blast hits to 947802 proteins in 35008 species: Archae - 20430; Bacteria - 568582; Metazoa - 213912; Fungi - 30250; Plants - 62241; Viruses - 64851; Other Eukaryotes - 27728 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      16336291..16340314
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119572.7 → NP_195137.5  poly(A) binding protein 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_195137.5

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P42731, Q8RXR5
      UniProtKB/TrEMBL
      A0A178UWB3, A0A5S9XYF9
      Conserved Domains (1) summary
      TIGR01628
      Location:37 → 612
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P42731.1

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