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    ADK1 adenosine kinase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820140, updated on 6-Oct-2023

    Summary

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    Gene symbol
    ADK1
    Gene description
    adenosine kinase 1
    Primary source
    Araport:AT3G09820
    Locus tag
    AT3G09820
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    adenosine kinase 1; ADENOSINE KINASE 1; ATADK1
    Summary
    Involved in the salvage synthesis of adenylates and methyl recycling
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    Genomic context

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    Location:
    chromosome: 3
    Exon count:
    12
    Sequence:
    Chromosome: 3; NC_003074.8 (3011780..3014944)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene ubiquitin 8 Neighboring gene SNARE-like superfamily protein Neighboring gene isocitrate dehydrogenase VI Neighboring gene Protein kinase superfamily protein Neighboring gene cell division cycle 48

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Adenosine kinase deficiency is associated with developmental abnormalities and reduced transmethylation. Moffatt BA, et al. Plant Physiol, 2002 Mar. PMID 11891238, Free PMC Article
    2. Inhibition of SNF1-related protein kinase1 activity and regulation of metabolic pathways by trehalose-6-phosphate. Zhang Y, et al. Plant Physiol, 2009 Apr. PMID 19193861, Free PMC Article
    3. Adenosine kinase of Arabidopsis. Kinetic properties and gene expression. Moffatt BA, et al. Plant Physiol, 2000 Dec. PMID 11115893, Free PMC Article
    4. Nuclear targeting of methyl-recycling enzymes in Arabidopsis thaliana is mediated by specific protein interactions. Lee S, et al. Mol Plant, 2012 Jan. PMID 21976714
    5. Proteomic survey of copper-binding proteins in Arabidopsis roots by immobilized metal affinity chromatography and mass spectrometry. Kung CC, et al. Proteomics, 2006 May. PMID 16526091

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The nuclear targeting of ADK1 and SAHH1 is mediated by their interaction with cap MT.
      Title: Nuclear targeting of methyl-recycling enzymes in Arabidopsis thaliana is mediated by specific protein interactions.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_111817.4
    NM_202540.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables adenosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables adenosine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables copper ion binding HDA PubMed 
    Process Evidence Code Pubs
    involved_in AMP salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within adenosine salvage TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within response to trehalose-6-phosphate IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apoplast HDA PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane HDA PubMed 
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    adenosine kinase 1
    NP_187593.1
    • adenosine kinase 1 (ADK1); FUNCTIONS IN: adenosine kinase activity, copper ion binding; INVOLVED IN: response to cadmium ion, response to trehalose-6-phosphate stimulus, adenosine salvage; LOCATED IN: cytosol, apoplast, plasma membrane, chloroplast, membrane; EXPRESSED IN: 33 plant structures; EXPRESSED DURING: 17 growth stages; CONTAINS InterPro DOMAIN/s: Carbohydrate/purine kinase (InterPro:IPR011611), Carbohydrate/puine kinase, PfkB, conserved site (InterPro:IPR002173), Adenosine kinase (InterPro:IPR001805); BEST Arabidopsis thaliana protein match is: adenosine kinase 2 (TAIR:AT5G03300.1); Has 9226 Blast hits to 9220 proteins in 1884 species: Archae - 142; Bacteria - 5715; Metazoa - 365; Fungi - 203; Plants - 345; Viruses - 0; Other Eukaryotes - 2456 (source: NCBI BLink).
    NP_974269.1
    • adenosine kinase 1 (ADK1); FUNCTIONS IN: adenosine kinase activity, copper ion binding; INVOLVED IN: response to cadmium ion, response to trehalose-6-phosphate stimulus, adenosine salvage; LOCATED IN: cytosol, apoplast, plasma membrane, membrane; EXPRESSED IN: 33 plant structures; EXPRESSED DURING: 17 growth stages; CONTAINS InterPro DOMAIN/s: Carbohydrate/purine kinase (InterPro:IPR011611), Carbohydrate/puine kinase, PfkB, conserved site (InterPro:IPR002173), Adenosine kinase (InterPro:IPR001805); BEST Arabidopsis thaliana protein match is: adenosine kinase 2 (TAIR:AT5G03300.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      3011780..3014944
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_111817.4 → NP_187593.1  adenosine kinase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187593.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3LFB3, Q9SF85
      UniProtKB/TrEMBL
      A0A178VJX9, A0A5S9XB83
      Conserved Domains (2) summary
      PLN02548
      Location:13 → 344
      PLN02548; adenosine kinase
      PTZ00247
      Location:10 → 343
      PTZ00247; adenosine kinase; Provisional

    2. NM_202540.1 → NP_974269.1  adenosine kinase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974269.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VJX9, A0A5S9XB83
      Conserved Domains (1) summary
      PLN02548
      Location:8 → 302
      PLN02548; adenosine kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SF85.1

    Gene LinkOut

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