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    PPC2 phosphoenolpyruvate carboxylase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818860, updated on 7-Sep-2023

    Summary

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    Gene symbol
    PPC2
    Gene description
    phosphoenolpyruvate carboxylase 2
    Primary source
    Araport:AT2G42600
    Locus tag
    AT2G42600
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATPPC2; F14N22.13; F14N22_13; phosphoenolpyruvate carboxylase 2
    Summary
    Encodes one of four Arabidopsis phosphoenolpyruvate carboxylase proteins.
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    Genomic context

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    Location:
    chromosome: 2
    Exon count:
    11
    Sequence:
    Chromosome: 2; NC_003071.7 (17734302..17739167, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene TRICHOME BIREFRINGENCE-LIKE 39 Neighboring gene tetratricopetide-repeat thioredoxin-like 3 Neighboring gene general regulatory factor 9 Neighboring gene LIGHT-DEPENDENT SHORT HYPOCOTYLS-like protein (DUF640) Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phosphoenolpyruvate Carboxylase in Arabidopsis Leaves Plays a Crucial Role in Carbon and Nitrogen Metabolism. Shi J, et al. Plant Physiol, 2015 Mar. PMID 25588735, Free PMC Article
    2. Phosphoenolpyruvate carboxylase (PEPC) and PEPC-kinase (PEPC-k) isoenzymes in Arabidopsis thaliana: role in control and abiotic stress conditions. Feria AB, et al. Planta, 2016 Oct. PMID 27306451
    3. Tandem affinity purification and mass spectrometric analysis of ubiquitylated proteins in Arabidopsis. Saracco SA, et al. Plant J, 2009 Jul. PMID 19292762, Free PMC Article
    4. Redox Conformation-Specific Protein-Protein Interactions of the 2-Cysteine Peroxiredoxin in Arabidopsis. Liebthal M, et al. Antioxidants (Basel), 2020 Jun 11. PMID 32545358, Free PMC Article
    5. Hydroponic isotope labelling of entire plants (HILEP) for quantitative plant proteomics; an oxidative stress case study. Bindschedler LV, et al. Phytochemistry, 2008 Jul. PMID 18538804

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phosphoenolpyruvate carboxylase (PEPC) activity was decreased in shoots and roots of ppc2 and ppc3 mutants, and phosphate starvation increased the expression of all PEPC and phosphoenolpyruvate carboxylase kinase genes in shoots, but only PPC3 and PPCK2 in roots.
      Title: Phosphoenolpyruvate carboxylase (PEPC) and PEPC-kinase (PEPC-k) isoenzymes in Arabidopsis thaliana: role in control and abiotic stress conditions.
    2. PEPC in leaves plays a crucial role in modulating the balance of carbon and nitrogen metabolism in Arabidopsis.
      Title: Phosphoenolpyruvate Carboxylase in Arabidopsis Leaves Plays a Crucial Role in Carbon and Nitrogen Metabolism.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001336987.1
    NM_180041.5
    NM_180042.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables phosphoenolpyruvate carboxylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within leaf development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in tricarboxylic acid cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apoplast HDA PubMed 
    located_in chloroplast HDA PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    phosphoenolpyruvate carboxylase 2
    NP_850372.4
    • phosphoenolpyruvate carboxylase 2 (PPC2); FUNCTIONS IN: phosphoenolpyruvate carboxylase activity, catalytic activity; INVOLVED IN: tricarboxylic acid cycle; LOCATED IN: cytosol, apoplast, chloroplast, plasma membrane; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Pyruvate/Phosphoenolpyruvate kinase, catalytic core (InterPro:IPR015813), Phosphoenolpyruvate carboxylase, active site (InterPro:IPR018129), Phosphoenolpyruvate carboxylase (InterPro:IPR001449), Phosphoenolpyruvate carboxylase, C-terminal region (InterPro:IPR021135); BEST Arabidopsis thaliana protein match is: phosphoenolpyruvate carboxylase 1 (TAIR:AT1G53310.3); Has 6860 Blast hits to 6799 proteins in 1908 species: Archae - 27; Bacteria - 2656; Metazoa - 4; Fungi - 0; Plants - 1774; Viruses - 0; Other Eukaryotes - 2399 (source: NCBI BLink).
    NP_850373.4
    • phosphoenolpyruvate carboxylase 2 (PPC2); FUNCTIONS IN: phosphoenolpyruvate carboxylase activity, catalytic activity; INVOLVED IN: tricarboxylic acid cycle; LOCATED IN: cytosol, apoplast, chloroplast, plasma membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Pyruvate/Phosphoenolpyruvate kinase, catalytic core (InterPro:IPR015813), Phosphoenolpyruvate carboxylase, active site (InterPro:IPR018129), Phosphoenolpyruvate carboxylase (InterPro:IPR001449), Phosphoenolpyruvate carboxylase, C-terminal region (InterPro:IPR021135); BEST Arabidopsis thaliana protein match is: phosphoenolpyruvate carboxylase 1 (TAIR:AT1G53310.3); Has 6860 Blast hits to 6799 proteins in 1908 species: Archae - 27; Bacteria - 2656; Metazoa - 4; Fungi - 0; Plants - 1774; Viruses - 0; Other Eukaryotes - 2399 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      17734302..17739167 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_180041.5 → NP_850372.4  phosphoenolpyruvate carboxylase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850372.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q5GM68, Q8GVE9, Q9SIN0
      UniProtKB/TrEMBL
      A0A178VV64, A0A5S9X6E1
      Conserved Domains (1) summary
      pfam00311
      Location:163 → 963
      PEPcase; Phosphoenolpyruvate carboxylase

    2. NM_001336987.1 → NP_001324501.1  phosphoenolpyruvate carboxylase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q5GM68, Q8GVE9, Q9SIN0
      UniProtKB/TrEMBL
      A0A178VV64, A0A5S9X6E1
      Conserved Domains (1) summary
      pfam00311
      Location:163 → 963
      PEPcase; Phosphoenolpyruvate carboxylase

    3. NM_180042.5 → NP_850373.4  phosphoenolpyruvate carboxylase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850373.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q5GM68, Q8GVE9, Q9SIN0
      UniProtKB/TrEMBL
      A0A178VV64, A0A5S9X6E1
      Conserved Domains (1) summary
      pfam00311
      Location:163 → 963
      PEPcase; Phosphoenolpyruvate carboxylase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5GM68.2

    Gene LinkOut

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