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    abcg2d ATP binding cassette subfamily G member 2 (JR blood group) [ Danio rerio (zebrafish) ]

    Gene ID: 735310, updated on 11-Apr-2024

    Summary

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    Official Symbol
    abcg2dprovided by ZNC
    Official Full Name
    ATP binding cassette subfamily G member 2 (JR blood group)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050517-38
    See related
    Ensembl:ENSDARG00000016818 AllianceGenome:ZFIN:ZDB-GENE-050517-38
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable ABC-type xenobiotic transporter activity and ATP binding activity. Predicted to act upstream of or within transmembrane transport. Predicted to be located in mitochondrial membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in gout; hematologic cancer (multiple); renal cell carcinoma; and toxic encephalopathy. Orthologous to human ABCG2 (ATP binding cassette subfamily G member 2 (Junior blood group)). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    chromosome: 1
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (50564405..50592738, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (49921254..49946800, complement)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101885315 Neighboring gene polycystic kidney disease 2 Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent 1Kb Neighboring gene HECT and RLD domain containing E3 ubiquitin protein ligase 56.1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Characterization and localization of side population (SP) cells in zebrafish kidney hematopoietic tissue. Kobayashi I, et al. Blood, 2008 Feb 1. PMID 17932252
    2. A novel ABC transporter: the first insight into zebrafish (Danio rerio) ABCH1. Popovic M, et al. Mar Environ Res, 2010. PMID 19926124
    3. Tanshinone I, a new EZH2 inhibitor restricts normal and malignant hematopoiesis through upregulation of MMP9 and ABCG2. Huang Y, et al. Theranostics, 2021. PMID 34093860, Free PMC Article
    4. Evolution of the vertebrate ABC gene family: analysis of gene birth and death. Annilo T, et al. Genomics, 2006 Jul. PMID 16631343
    5. Evolution of the ATP-binding cassette (ABC) transporter superfamily in vertebrates. Dean M, et al. Annu Rev Genomics Hum Genet, 2005. PMID 16124856

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables efflux transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables riboflavin transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ATP-binding cassette sub-family G member 2; broad substrate specificity ATP-binding cassette transporter ABCG2d
    Names
    ATP-binding cassette transporter sub-family G member 2d
    ATP-binding cassette, sub-family G (WHITE), member 2d

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042772.1 → NP_001036237.1  broad substrate specificity ATP-binding cassette transporter ABCG2d

      See identical proteins and their annotated locations for NP_001036237.1

      Status: PROVISIONAL

      Source sequence(s)
      DQ223861
      UniProtKB/TrEMBL
      A0A8M1N9B0, Q2Q444
      Related
      ENSDARP00000024285.6, ENSDART00000022733.7
      Conserved Domains (3) summary
      TIGR01166
      Location:65 → 246
      cbiO; cobalt transport protein ATP-binding subunit
      cd03213
      Location:37 → 271
      ABCG_EPDR; Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily
      pfam01061
      Location:382 → 567
      ABC2_membrane; ABC-2 type transporter

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      50564405..50592738 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009294223.3 → XP_009292498.3  ATP-binding cassette sub-family G member 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M3B3I6
      Conserved Domains (1) summary
      cl28180
      Location:56 → 658
      PRK10535; macrolide transporter ATP-binding /permease protein; Provisional
    Nucleotide Protein
    Heading Accession and Version

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