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    eIF4G1 eukaryotic translation initiation factor 4G1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43839, updated on 26-Apr-2024

    Summary

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    Official Symbol
    eIF4G1provided by FlyBase
    Official Full Name
    eukaryotic translation initiation factor 4G1provided by FlyBase
    Primary source
    FLYBASE:FBgn0023213
    Locus tag
    Dmel_CG10811
    See related
    AllianceGenome:FB:FBgn0023213
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10811; deIF4G; Dmel\CG10811; eiF-4G; eIF-4G; eIF4g; eIF4G; Eif4G; EIF4G; EIF4G1; p200
    Summary
    Enables RNA 7-methylguanosine cap binding activity and eukaryotic initiation factor 4E binding activity. Involved in regulation of translation and translation. Located in cytosol. Part of eukaryotic translation initiation factor 4F complex. Is expressed in several structures, including adult head and gonad. Human ortholog(s) of this gene implicated in late onset Parkinson's disease. Orthologous to several human genes including EIF4G3 (eukaryotic translation initiation factor 4 gamma 3). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    102F1-102F1; 4-0 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (915297..930715, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (935923..951341, complement)

    Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene unc-13 Neighboring gene antisense RNA:CR44029 Neighboring gene pseudo Neighboring gene metabotropic Glutamate Receptor Neighboring gene eIF4E-Transporter

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The influence of microRNAs and poly(A) tail length on endogenous mRNA-protein complexes. Rissland OS, et al. Genome Biol, 2017 Oct 31. PMID 29089021, Free PMC Article
    2. How strong is the case for regulation of the initiation step of translation by elements at the 3' end of eukaryotic mRNAs? Kozak M. Gene, 2004 Dec 8. PMID 15563830
    3. Isolation and characterization of the cDNA and the gene for eukaryotic translation initiation factor 4G from Drosophila melanogaster. Hernández G, et al. Eur J Biochem, 1998 Apr 1. PMID 9578457
    4. Molecular architecture of 4E-BP translational inhibitors bound to eIF4E. Peter D, et al. Mol Cell, 2015 Mar 19. PMID 25702871
    5. Drosophila Cup is an eIF4E-binding protein that functions in Smaug-mediated translational repression. Nelson MR, et al. EMBO J, 2004 Jan 14. PMID 14685270, Free PMC Article

    See all (134) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The structures of eIF4E-eIF4G complexes reveal an extended interface to regulate translation initiation.
      Title: The Structures of eIF4E-eIF4G Complexes Reveal an Extended Interface to Regulate Translation Initiation.
    2. Phosphorylation of 4E-BP1 impairs the competition with eIF4G for eIF4E binding.
      Title: Molecular architecture of 4E-BP translational inhibitors bound to eIF4E.
    3. The eIF4G knockdown did not affect male fertility.
      Title: Loss-of-function analysis reveals distinct requirements of the translation initiation factors eIF4E, eIF4E-3, eIF4G and eIF4G2 in Drosophila spermatogenesis.
    4. Data show that in the early embryo dFMRP associates specifically with Caprin, and with eIF4G, a key regulator of translational initiation.
      Title: dFMRP and Caprin, translational regulators of synaptic plasticity, control the cell cycle at the Drosophila mid-blastula transition.
    5. A novel eIF4G homolog, Off-schedule, couples translational control to meiosis and differentiation in Drosophila spermatocytes.
      Title: A novel eIF4G homolog, Off-schedule, couples translational control to meiosis and differentiation in Drosophila spermatocytes.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c916770-916646 mobile_element_type = transposon:INE-1{}2754
    • Loc: c921870-921371 mobile_element_type = transposon:INE-1{}2770
    • Loc: c924378-924020 mobile_element_type = transposon:HB{}5410

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA 7-methylguanosine cap binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic initiation factor 4E binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation initiation factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitotic cell cycle HMP PubMed 
    involved_in translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of eukaryotic translation initiation factor 4F complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic translation initiation factor 4F complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of eukaryotic translation initiation factor 4F complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 4G1
    Names
    CG10811-PA
    CG10811-PB
    CG10811-PC
    Eukaryotic-initiation-factor-4G
    eIF-4G
    eIF4G1-PA
    eIF4G1-PB
    eIF4G1-PC
    eukaryotic
    eukaryotic initiation factor 4G
    eukaryotic translation initiation factor 4G
    translation initiation factor
    translation initiation factor 4G
    translation initiation factor eIF4G

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004353.4 Reference assembly

      Range
      915297..930715 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079901.4 → NP_524640.3  eukaryotic translation initiation factor 4G1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524640.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      O61380, Q7KQ11
      Conserved Domains (4) summary
      cd11559
      Location:1511 → 1642
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      pfam09606
      Location:1 → 199
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam02847
      Location:1309 → 1424
      MA3; MA3 domain
      pfam02854
      Location:751 → 999
      MIF4G; MIF4G domain

    2. NM_001103382.2 → NP_001096852.1  eukaryotic translation initiation factor 4G1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001096852.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DZ29
      Conserved Domains (3) summary
      cd11559
      Location:1764 → 1895
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      pfam02847
      Location:1562 → 1677
      MA3; MA3 domain
      pfam02854
      Location:1004 → 1252
      MIF4G; MIF4G domain

    3. NM_001144385.2 → NP_001137857.1  eukaryotic translation initiation factor 4G1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137857.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O61380, Q7KQ11
      Conserved Domains (4) summary
      cd11559
      Location:1511 → 1642
      W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
      pfam09606
      Location:1 → 199
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam02847
      Location:1309 → 1424
      MA3; MA3 domain
      pfam02854
      Location:751 → 999
      MIF4G; MIF4G domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8DZ29 A8DZ29
    O61380 O61380
    Q7YU50 Q7YU50

    Gene LinkOut

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