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    hnrpkl heterogeneous nuclear ribonucleoprotein K, like [ Danio rerio (zebrafish) ]

    Gene ID: 406264, updated on 25-Apr-2024

    Summary

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    Official Symbol
    hnrpklprovided by ZNC
    Official Full Name
    heterogeneous nuclear ribonucleoprotein K, likeprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1923
    See related
    Ensembl:ENSDARG00000007034 AllianceGenome:ZFIN:ZDB-GENE-040426-1923
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:56206; wu:fc19f05; wu:fc48a08; wu:fc84b09; wu:fd16g02
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in regulation of mRNA splicing, via spliceosome and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in nucleoplasm. Predicted to be part of spliceosomal complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human HNRNPK (heterogeneous nuclear ribonucleoprotein K). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    chromosome: 5
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (55603855..55625297, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (54933638..54955050, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene guanine nucleotide binding protein (G protein), alpha 14 Neighboring gene microRNA 7ba Neighboring gene guanine nucleotide binding protein (G protein), q polypeptide Neighboring gene neurotrophic tyrosine kinase, receptor, type 2b Neighboring gene uncharacterized LOC110439833 Neighboring gene potassium channel modulatory factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Mutagenesis Screen Identifies agtpbp1 and eps15L1 as Essential for T lymphocyte Development in Zebrafish. Seiler C, et al. PLoS One, 2015. PMID 26161877, Free PMC Article
    2. Evolution after Whole-Genome Duplication: Teleost MicroRNAs. Desvignes T, et al. Mol Biol Evol, 2021 Jul 29. PMID 33871629, Free PMC Article
    3. Proteome dynamics in neutrophils of adult zebrafish upon chemically-induced inflammation. Singh SK, et al. Fish Shellfish Immunol, 2014 Sep. PMID 25014315
    4. Microarray gene expression profiling during the segmentation phase of zebrafish development. Linney E, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2004 Jul. PMID 15533793
    5. The SARS-CoV-2 receptor and other key components of the Renin-Angiotensin-Aldosterone System related to COVID-19 are expressed in enterocytes in larval zebrafish. Postlethwait JH, et al. Biol Open, 2021 Mar 23. PMID 33757938, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    heterogeneous nuclear ribonucleoprotein K; heterogeneous nuclear ribonucleoprotein K, like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212991.3 → NP_998156.3  heterogeneous nuclear ribonucleoprotein K, like

      Status: VALIDATED

      Source sequence(s)
      CT708088, CU468920, EB831522
      UniProtKB/TrEMBL
      A0A8M1PG37, B8JLJ8
      Related
      ENSDARP00000116598.1, ENSDART00000133156.3
      Conserved Domains (3) summary
      cd00105
      Location:357 → 420
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd02396
      Location:123 → 187
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
      pfam08067
      Location:10 → 44
      ROKNT; ROKNT (NUC014) domain

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      55603855..55625297 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009301843.3 → XP_009300118.1  heterogeneous nuclear ribonucleoprotein K isoform X1

      UniProtKB/TrEMBL
      A0A8M3ASQ8, F6PB84
      Related
      ENSDARP00000008648.10, ENSDART00000005671.10
      Conserved Domains (3) summary
      cd00105
      Location:346 → 409
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd02396
      Location:123 → 187
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
      pfam08067
      Location:10 → 44
      ROKNT; ROKNT (NUC014) domain
    Nucleotide Protein Strain
    Heading Accession and Version

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