pam16 presequence translocase associated motor 16 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pam16provided by ZNC
Official Full Name: presequence translocase associated motor 16provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1776
See related: Ensembl:ENSDARG00000102822 AllianceGenome:ZFIN:ZDB-GENE-040426-1776
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: magmas; timm16; zgc:73356
Summary: Predicted to be involved in protein import into mitochondrial matrix. Predicted to act upstream of or within protein transport. Predicted to be located in mitochondrial inner membrane. Predicted to be part of TIM23 mitochondrial import inner membrane translocase complex. Human ortholog(s) of this gene implicated in spondylometaphyseal dysplasia Megarbane-Dagher-Melike type. Orthologous to human PAM16 (presequence translocase associated motor 16). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (12345276..12352795, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (12192333..12199852, complement)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in protein import into mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein import into mitochondrial matrix	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of TIM23 mitochondrial import inner membrane translocase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of TIM23 mitochondrial import inner membrane translocase complex	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mitochondrial import inner membrane translocase subunit tim16

Names: magmas-like protein; mitochondria-associated granulocyte macrophage CSF signaling molecule; mitochondria-associated protein involved in granulocyte-macrophage colony-stimulating factor signal transduction; presequence translocase-associated motor 16 homolog; presequence translocated-associated motor subunit pam16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200804.2 → NP_957098.2 mitochondrial import inner membrane translocase subunit tim16

Status: VALIDATED

Source sequence(s)

CT033841

UniProtKB/Swiss-Prot

Q6PBL0

UniProtKB/TrEMBL

A0A0R4IJF5, A0A8M1PF25

Related

ENSDARP00000133623.1, ENSDART00000165013.2

Conserved Domains (1) summary

cl02542
Location:1 → 118

DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...