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    Eaf6 Esa1-associated factor 6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38637, updated on 10-May-2024

    Summary

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    Official Symbol
    Eaf6provided by FlyBase
    Official Full Name
    Esa1-associated factor 6provided by FlyBase
    Primary source
    FLYBASE:FBgn0035624
    Locus tag
    Dmel_CG12756
    See related
    AllianceGenome:FB:FBgn0035624
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12756; dEaf6; Dmel\CG12756
    Summary
    Enables acetyltransferase activator activity. Involved in histone H3 acetylation and regulation of cell cycle. Part of MOZ/MORF histone acetyltransferase complex and NuA4 histone acetyltransferase complex. Is expressed in organism. Orthologous to human MEAF6 (MYST/Esa1 associated factor 6). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Eaf6 in Genome Data Viewer
    Location:
    64D6-64D6; 3-14 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (5607162..5608300, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (5600262..5601400, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Transmembrane 9 superfamily protein member 3 Neighboring gene methuselah-like 2 Neighboring gene Blimp-1 Neighboring gene lin-28

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Enok acetyltransferase complex interacts with Elg1 and negatively regulates PCNA unloading to promote the G1/S transition. Huang F, et al. Genes Dev, 2016 May 15. PMID 27198229, Free PMC Article
    2. In Vivo Silencing of Genes Coding for dTip60 Chromatin Remodeling Complex Subunits Affects Polytene Chromosome Organization and Proper Development in Drosophila melanogaster. Prozzillo Y, et al. Int J Mol Sci, 2021 Apr 26. PMID 33926075, Free PMC Article
    3. Bivalent complexes of PRC1 with orthologs of BRD4 and MOZ/MORF target developmental genes in Drosophila. Kang H, et al. Genes Dev, 2017 Oct 1. PMID 29070704, Free PMC Article
    4. In and out: histone variant exchange in chromatin. Jin J, et al. Trends Biochem Sci, 2005 Dec. PMID 16257529
    5. Drosophila SWR1 and NuA4 complexes are defined by DOMINO isoforms. Scacchetti A, et al. Elife, 2020 May 20. PMID 32432549, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables acetyltransferase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MOZ/MORF histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NuA4 histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of histone acetyltransferase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Esa1-associated factor 6
    Names
    CG12756-PA
    Eaf6-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      5607162..5608300 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139724.4 → NP_647981.1  Esa1-associated factor 6 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647981.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VRN3
      Related
      FBpp0076832
      Conserved Domains (1) summary
      pfam09340
      Location:36 → 113
      NuA4; Histone acetyltransferase subunit NuA4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VRN3.1 Q9VRN3

    Gene LinkOut

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