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    Dp DP transcription factor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36461, updated on 26-Apr-2024

    Summary

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    Official Symbol
    Dpprovided by FlyBase
    Official Full Name
    DP transcription factorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0011763
    Locus tag
    Dmel_CG4654
    See related
    AllianceGenome:FB:FBgn0011763
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    49Fk; CG4654; dDp; dDP; dDP1; DDP1; DmDP; Dmel\CG4654; dp; DP; Dp1; DP1; l(2)49Fk; l(2)vr10; TFPD2; vr10
    Summary
    Enables DNA binding activity. Contributes to DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in several processes, including dorsal/ventral axis specification, ovarian follicular epithelium; intrinsic apoptotic signaling pathway in response to DNA damage; and positive regulation of nurse cell apoptotic process. Located in nucleus. Part of Myb complex and Rb-E2F complex. Is expressed in several structures, including embryonic/larval muscle system; extended germ band embryo; gut section; imaginal disc; and testis. Orthologous to several human genes including TFDP1 (transcription factor Dp-1) and TFDP2 (transcription factor Dp-2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    49F10-49F11; 2-68 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (13222433..13228202)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (9109938..9115707)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene F-box synaptic protein Neighboring gene long non-coding RNA:CR43918 Neighboring gene Peroxin 13 Neighboring gene fates-shifted

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptional dysregulation by a nucleus-localized aminoacyl-tRNA synthetase associated with Charcot-Marie-Tooth neuropathy. Bervoets S, et al. Nat Commun, 2019 Nov 6. PMID 31695036, Free PMC Article
    2. Loss of dE2F compromises mitochondrial function. Ambrus AM, et al. Dev Cell, 2013 Nov 25. PMID 24286825, Free PMC Article
    3. DNA-binding and trans-activation properties of Drosophila E2F and DP proteins. Dynlacht BD, et al. Proc Natl Acad Sci U S A, 1994 Jul 5. PMID 8022787, Free PMC Article
    4. E2F/Dp inactivation in fat body cells triggers systemic metabolic changes. Zappia MP, et al. Elife, 2021 Jul 12. PMID 34251339, Free PMC Article
    5. E2F/DP Prevents Cell-Cycle Progression in Endocycling Fat Body Cells by Suppressing dATM Expression. Guarner A, et al. Dev Cell, 2017 Dec 18. PMID 29233476, Free PMC Article

    See all (245) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These findings identify a key function of E2F/Dp in skeletal muscle required for animal viability, and illustrate how the cell cycle regulator is repurposed in post-mitotic cells.
      Title: E2F function in muscle growth is necessary and sufficient for viability in Drosophila.
    2. results suggest that E2F/DP complexes are essential for all genomic targeting of RBF1
      Title: RBF binding to both canonical E2F targets and noncanonical targets depends on functional dE2F/dDP complexes.
    3. Dampened transcriptional activation by E2F1-DP and Myb-MuvB is important to repress mitosis and coordinate the endocycle transcription
      Title: Dampened activity of E2F1-DP and Myb-MuvB transcription factors in Drosophila endocycling cells.
    4. dDP is required for normal cell proliferation, for optimal DNA synthesis, and for efficient G2/M progression.
      Title: dDP is needed for normal cell proliferation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to DNA-binding transcription factor activity, RNA polymerase II-specific IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to sequence-specific DNA binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in dorsal/ventral axis specification, ovarian follicular epithelium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in eggshell chorion gene amplification TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in endomitotic cell cycle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nurse cell apoptotic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of nurse cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Myb complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Rb-E2F complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription regulator complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DP transcription factor
    Names
    CG4654-PA
    CG4654-PB
    CG4654-PC
    Dp-PA
    Dp-PB
    Dp-PC
    dimerization partner
    lethal(2)49Fk

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      13222433..13228202
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057691.4 → NP_477039.1  DP transcription factor, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477039.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B8A3X4, O17472, O44080, Q24318, Q86PE0, Q8ML56, Q9V6M0
      Related
      FBpp0086853
      Conserved Domains (3) summary
      cd14458
      Location:248 → 294
      DP_DD; coiled coil [structural motif]
      pfam02319
      Location:167 → 243
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam08781
      Location:255 → 388
      DP; Transcription factor DP

    2. NM_001274020.1 → NP_001260949.1  DP transcription factor, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260949.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KEQ0
      Conserved Domains (3) summary
      cd14458
      Location:220 → 266
      DP_DD; coiled coil [structural motif]
      pfam02319
      Location:139 → 215
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam08781
      Location:227 → 360
      DP; Transcription factor DP

    3. NM_165974.3 → NP_725267.1  DP transcription factor, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725267.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24318
      Related
      FBpp0086854
      Conserved Domains (3) summary
      cd14458
      Location:244 → 290
      DP_DD; coiled coil [structural motif]
      pfam02319
      Location:163 → 239
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam08781
      Location:251 → 384
      DP; Transcription factor DP
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KEQ0 A0A0B4KEQ0
    Q24318.2 Q24318
    Q7KPZ3 Q7KPZ3

    Gene LinkOut

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