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    Tsp39D Tetraspanin 39D [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35405, updated on 26-Apr-2024

    Summary

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    Official Symbol
    Tsp39Dprovided by FlyBase
    Official Full Name
    Tetraspanin 39Dprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032943
    Locus tag
    Dmel_CG8666
    See related
    AllianceGenome:FB:FBgn0032943
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8666; Dm.Tsp39D; Dmel\CG8666
    Summary
    Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 58. Orthologous to several human genes including CD63 (CD63 molecule). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    39D1-39D1; 2-54 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (21344607..21358271)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (21344607..21358271)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR42696 Neighboring gene dimmed Neighboring gene defective transmitter release Neighboring gene Gustatory receptor 39b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptional regulation of neuropeptide and peptide hormone expression by the Drosophila dimmed and cryptocephal genes. Gauthier SA, et al. J Exp Biol, 2006 May. PMID 16651547
    2. Transcriptional Feedback Links Lipid Synthesis to Synaptic Vesicle Pools in Drosophila Photoreceptors. Tsai JW, et al. Neuron, 2019 Feb 20. PMID 30737130, Free PMC Article
    3. Involvement of CD9 and PDGFR in migration is evolutionarily conserved from Drosophila glia to human glioma. Jeibmann A, et al. J Neurooncol, 2015 Sep. PMID 26224160
    4. Genomewide analysis of the Drosophila tetraspanins reveals a subset with similar function in the formation of the embryonic synapse. Fradkin LG, et al. Proc Natl Acad Sci U S A, 2002 Oct 15. PMID 12370414, Free PMC Article
    5. The tetraspanin superfamily in insects. Todres E, et al. Insect Mol Biol, 2000 Dec. PMID 11122467

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 21346079-21346291 mobile_element_type = transposon:INE-1{}2236
    • Loc: 21346329-21347214 mobile_element_type = transposon:INE-1{}4114
    • Loc: 21347605-21355019 mobile_element_type = transposon:blood{}488

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tetraspanin 39D
    Names
    CG8666-PB
    Tsp39D-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      21344607..21358271
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078888.4 → NP_523612.3  tetraspanin 39D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523612.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NR56, Q9VID1
      Conserved Domains (2) summary
      cd03127
      Location:104 → 200
      tetraspanin_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the ...
      pfam00335
      Location:8 → 227
      Tetraspannin; Tetraspanin family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VID1 Q9VID1

    Gene LinkOut

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