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    Zfp136 zinc finger protein 136 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291802, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Zfp136provided by RGD
    Official Full Name
    zinc finger protein 136provided by RGD
    Primary source
    RGD:1565635
    See related
    AllianceGenome:RGD:1565635
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565635
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 59.3), Brain (RPKM 47.8) and 9 other tissues See more
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    Genomic context

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    Location:
    18p13
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (882417..891029)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (609472..618190)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (746647..755267)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 665-like Neighboring gene zinc finger protein 501-like Neighboring gene cyclin B2, pseudogene 1 Neighboring gene WW domain binding protein 1-like, pseudogene 2 Neighboring gene centrin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 136
    Names
    zinc finger protein 709

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001408853.1 → NP_001395782.1  zinc finger protein 136

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      882417..891029
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006254395.5 → XP_006254457.1  zinc finger protein 136 isoform X1

      See identical proteins and their annotated locations for XP_006254457.1

      Conserved Domains (3) summary
      COG5048
      Location:135 → 502
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:250 → 269
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:485 → 510
      zf-H2C2_2; Zinc-finger double domain

    2. XM_063277275.1 → XP_063133345.1  zinc finger protein 136 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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