U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    CRYBB2 crystallin beta B2 [ Bos taurus (cattle) ]

    Gene ID: 287011, updated on 5-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CRYBB2provided by VGNC
    Official Full Name
    crystallin beta B2provided by VGNC
    Primary source
    VGNC:VGNC:27737
    See related
    BGD:BT10539; Ensembl:ENSBTAG00000004088
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    chromosome: 17
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 17 NC_037344.1 (65304388..65318606)

    Chromosome 17 - NC_037344.1Genomic Context describing neighboring genes Neighboring gene KIAA1671 Neighboring gene uncharacterized LOC132342637 Neighboring gene crystallin beta B3 Neighboring gene uncharacterized LOC112442007 Neighboring gene uncharacterized LOC132342638

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_037344.1 Chromosome 17 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. 1H-NMR spectroscopy of beta B2-crystallin from bovine eye lens. Conformation of the N- and C-terminal extensions. Carver JA, et al. Eur J Biochem, 1993 Apr 1. PMID 8477703
    2. Primary structure of the bovine beta-crystallin Bp chain. Internal duplication and homology with gamma-crystallin. Driessen HP, et al. Eur J Biochem, 1981 Dec. PMID 7035168
    3. Nucleotide sequence for the cDNA of the bovine beta B2 crystallin and assignment of the orthologous human locus to chromosome 22. Hogg D, et al. Curr Eye Res, 1987 Nov. PMID 3427982
    4. X-ray analysis of beta B2-crystallin and evolution of oligomeric lens proteins. Bax B, et al. Nature, 1990 Oct 25. PMID 2234050
    5. Detection and structural features of the betaB2-B3-crystallin heterodimer by radical probe mass spectrometry (RP-MS). Diemer H, et al. J Mass Spectrom, 2009 May. PMID 19206113

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. detection & sructure of the betaB2-B3-crystallin heterodimer; results suggest the betaB2 subunit adopts a more compacted form than in its monomeric form in order for much of its structure to be enveloped by the betaB3 subunit within the heterodimer
      Title: Detection and structural features of the betaB2-B3-crystallin heterodimer by radical probe mass spectrometry (RP-MS).
    2. combined with previously reported observations of alpha-crystallin quaternary structure have led us to propose a structural model of how activated alpha-crystallin chaperones unfolded betaB2-crystallin
      Title: Association of partially folded lens betaB2-crystallins with the alpha-crystallin molecular chaperone.
    3. Mass spectrometry analysis and a database search identified carbamylated proteins originating from alphaA-crystallin, betaB2- and gammaS-(betaS)-crystallins.
      Title: Identification of the primary targets of carbamylation in bovine lens proteins by mass spectrometry.
    4. Results show that both betaB2- and betaA3-crystallin bind calcium with moderate affinity.
      Title: Calcium-binding to lens betaB2- and betaA3-crystallins suggests that all beta-crystallins are calcium-binding proteins.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables structural constituent of eye lens IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lens development in camera-type eye IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in visual perception IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    beta-crystallin B2
    Names
    beta-B2 crystallin
    beta-crystallin Bp

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174807.1 → NP_777232.1  beta-crystallin B2

      See identical proteins and their annotated locations for NP_777232.1

      Status: PROVISIONAL

      Source sequence(s)
      M22466
      UniProtKB/Swiss-Prot
      P02522
      Related
      ENSBTAP00000005341.2, ENSBTAT00000005341.4
      Conserved Domains (2) summary
      smart00247
      Location:18 → 100
      XTALbg; Beta/gamma crystallins
      pfam00030
      Location:108 → 190
      Crystall; Beta/Gamma crystallin

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037344.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      65304388..65318606
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024977034.1 → XP_024832802.1  beta-crystallin B2 isoform X1

      UniProtKB/Swiss-Prot
      P02522
      Conserved Domains (2) summary
      smart00247
      Location:18 → 100
      XTALbg; Beta/gamma crystallins
      pfam00030
      Location:108 → 190
      Crystall; Beta/Gamma crystallin
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P02522.3 GenPept UniProtKB/Swiss-Prot:P02522

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.