U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    gst-5 GST C-terminal domain-containing protein;putative glutathione S-transferase 5 [ Caenorhabditis elegans ]

    Gene ID: 187537, updated on 25-Apr-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    gst-5
    Gene description
    GST C-terminal domain-containing protein;putative glutathione S-transferase 5
    Primary source
    WormBase:WBGene00001753
    Locus tag
    CELE_R03D7.6
    See related
    AllianceGenome:WB:WBGene00001753
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable glutathione transferase activity. Involved in innate immune response. Is expressed in intestine; nerve ring; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung disease (multiple). Orthologous to several human genes including HPGDS (hematopoietic prostaglandin D synthase). [provided by Alliance of Genome Resources, Apr 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    chromosome: II
    Exon count:
    2
    Sequence:
    Chromosome: II; NC_003280.10 (10950352..10951603)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Phage protein Neighboring gene Transcription elongation factor B polypeptide 3 Neighboring gene Protein kinase domain-containing protein;Putative serine/threonine-protein kinase R03D7.5 Neighboring gene Nanos-type domain-containing protein Neighboring gene Serine/threonine specific protein phosphatases domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Structural and functional analysis of a glutathione S-transferase from Ascaris suum. Liebau E, et al. Biochem J, 1997 Jun 1. PMID 9182731, Free PMC Article
    2. Heme transport and detoxification in nematodes: subproteomics evidence of differential role of glutathione transferases. Perally S, et al. J Proteome Res, 2008 Oct. PMID 18720983
    3. Tris(1,3-dichloro-2-propyl) phosphate accelerated the aging process induced by the 4-hydroxynon-2-enal response to reactive oxidative species in Caenorhabditis elegans. Wang C, et al. Environ Pollut, 2019 Mar. PMID 31159140
    4. A proteomics approach to quantify protein levels following RNA interference: case study with glutathione transferase superfamily from the model metazoan Caenorhabditis elegans. Lacourse EJ, et al. J Proteome Res, 2008 Aug. PMID 18582093
    5. Insecticidal activity and mechanism of cinnamaldehyde in C. elegans. Lu L, et al. Fitoterapia, 2020 Oct. PMID 32681860

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response HEP PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    GST C-terminal domain-containing protein;putative glutathione S-transferase 5
    NP_001254267.1
    • Confirmed by transcript evidence
    NP_001254269.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      10950352..10951603
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001267338.3 → NP_001254267.1  putative glutathione S-transferase 5 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254267.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09596
      Conserved Domains (2) summary
      cd03192
      Location:85 → 189
      GST_C_Sigma_like; C-terminal, alpha helical domain of Class Sigma-like Glutathione S-transferases
      cd03039
      Location:4 → 75
      GST_N_Sigma_like; GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of ...

    2. NM_001267340.3 → NP_001254269.1  GST C-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254269.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G3MTX8
      Conserved Domains (1) summary
      pfam14497
      Location:3 → 91
      GST_C_3; Glutathione S-transferase, C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    1ZL9_A.1
    1ZL9_B.1
    Q09596.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous