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    unc-7 Innexin;Innexin unc-7 [ Caenorhabditis elegans ]

    Gene ID: 181608, updated on 25-Apr-2024

    Summary

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    Gene symbol
    unc-7
    Gene description
    Innexin;Innexin unc-7
    Primary source
    WormBase:WBGene00006747
    Locus tag
    CELE_R07D5.1
    See related
    AllianceGenome:WB:WBGene00006747
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables gap junction channel activity. Involved in several processes, including oviposition; response to anesthetic; and spicule insertion. Located in gap junction and neuron projection membrane. Is expressed in several structures, including OL socket cell; g1AR; muscle cell; neurons; and pharyngeal gland cell. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: X
    Exon count:
    15
    Sequence:
    Chromosome: X; NC_003284.9 (15120846..15147740, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Arg Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A co-operative regulation of neuronal excitability by UNC-7 innexin and NCA/NALCN leak channel. Bouhours M, et al. Mol Brain, 2011 Apr 13. PMID 21489288, Free PMC Article
    2. Molecular basis of junctional current rectification at an electrical synapse. Shui Y, et al. Sci Adv, 2020 Jul. PMID 32923588, Free PMC Article
    3. Distinct roles for innexin gap junctions and hemichannels in mechanosensation. Walker DS, et al. Elife, 2020 Jan 29. PMID 31995033, Free PMC Article
    4. Descending pathway facilitates undulatory wave propagation in Caenorhabditis elegans through gap junctions. Xu T, et al. Proc Natl Acad Sci U S A, 2018 May 8. PMID 29686107, Free PMC Article
    5. An imbalancing act: gap junctions reduce the backward motor circuit activity to bias C. elegans for forward locomotion. Kawano T, et al. Neuron, 2011 Nov 17. PMID 22099460

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study showed that isoform, which perturbs DOP-2 signaling in the PCB neuron and its electrical partner, hook neurons.
      Title: DOP-2 D2-Like Receptor Regulates UNC-7 Innexins to Attenuate Recurrent Sensory Motor Neurons during C. elegans Copulation.
    2. UNC-7S and UNC-9 are widely expressed and contribute to a large number of the gap junctions identified in the locomotory.nervous system.
      Title: Interactions between innexins UNC-7 and UNC-9 mediate electrical synapse specificity in the Caenorhabditis elegans locomotory nervous system.
    3. UNC-7 is localized perisynaptically throughout development and is required in presynaptic neurons to regulate active zone differentiation.
      Title: Caenorhabditis elegans innexins regulate active zone differentiation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables gap junction channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables gap junction channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables gap junction channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables gap junction hemi-channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to dopamine IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in egg-laying behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gap junction assembly TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of locomotion involved in locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of male mating behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of nematode pharyngeal pumping IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of nematode pharyngeal pumping IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of neuronal signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to anesthetic IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in spicule insertion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in gap junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in gap junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in gap junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in neuron projection membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Innexin;Innexin unc-7
    NP_001257255.1
    • Confirmed by transcript evidence
    NP_001257256.1
    • Partially confirmed by transcript evidence
    NP_001337312.1
    • Partially confirmed by transcript evidence
    NP_001337313.1
    • Partially confirmed by transcript evidence
    NP_001337316.1
    • Partially confirmed by transcript evidence
    NP_001337317.1
    • Partially confirmed by transcript evidence
    NP_001337318.1
    • Confirmed by transcript evidence
    NP_001337319.1
    • Confirmed by transcript evidence
    NP_001337320.1
    • Confirmed by transcript evidence
    NP_001379507.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      15120846..15147740 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001350356.3 → NP_001337319.1  Innexin [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1T5HUM7
      Conserved Domains (1) summary
      pfam00876
      Location:93 → 453
      Innexin

    2. NM_001270326.3 → NP_001257255.1  Innexin unc-7 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001257255.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q03412
      Conserved Domains (1) summary
      pfam00876
      Location:139 → 501
      Innexin; Innexin

    3. NM_001350352.4 → NP_001337313.1  Innexin [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1T5HUM1
      Conserved Domains (1) summary
      pfam00876
      Location:163 → 523
      Innexin

    4. NM_001350354.3 → NP_001337317.1  Innexin [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1T5HUM6
      Conserved Domains (1) summary
      pfam00876
      Location:80 → 440
      Innexin

    5. NM_001392896.1 → NP_001379507.1  Innexin [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      C8JQR8
      Conserved Domains (1) summary
      pfam00876
      Location:20 → 380
      Innexin

    6. NM_001350353.4 → NP_001337312.1  Innexin [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1T5HUM5
      Conserved Domains (1) summary
      pfam00876
      Location:163 → 525
      Innexin

    7. NM_001350355.3 → NP_001337316.1  Innexin [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1T5HUM3
      Conserved Domains (1) summary
      pfam00876
      Location:80 → 442
      Innexin

    8. NM_001350357.3 → NP_001337318.1  Innexin [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1T5HUM9
      Conserved Domains (1) summary
      pfam00876
      Location:93 → 455
      Innexin

    9. NM_001350358.3 → NP_001337320.1  Innexin [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1T5HUN4
      Conserved Domains (1) summary
      pfam00876
      Location:139 → 499
      Innexin

    10. NM_001270327.3 → NP_001257256.1  Innexin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001257256.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C8JQR7
      Conserved Domains (1) summary
      pfam00876
      Location:71 → 433
      Innexin; Innexin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03412.1

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