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    sma-5 Mitogen-activated protein kinase sma-5;Protein kinase domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 181373, updated on 25-Apr-2024

    Summary

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    Gene symbol
    sma-5
    Gene description
    Mitogen-activated protein kinase sma-5;Protein kinase domain-containing protein
    Primary source
    WormBase:WBGene00004859
    Locus tag
    CELE_W06B3.2
    See related
    AllianceGenome:WB:WBGene00004859
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable MAP kinase activity. Involved in several processes, including determination of adult lifespan; parturition; and positive regulation of cell size. Predicted to be active in cytoplasm and nucleus. Is expressed in excretory cell; hypodermis; intestine; and pharynx. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: X
    Exon count:
    10
    Sequence:
    Chromosome: X; NC_003284.9 (11997524..12005004, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene tRNA-His Neighboring gene Acyl carrier protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel function for the MAP kinase SMA-5 in intestinal tube stability. Geisler F, et al. Mol Biol Cell, 2016 Dec 1. PMID 27733627, Free PMC Article
    2. Control of body size by SMA-5, a homolog of MAP kinase BMK1/ERK5, in C. elegans. Watanabe N, et al. Development, 2005 Jul. PMID 15944183
    3. Mutants carrying two sma mutations are super small in the nematode C. elegans. Watanabe N, et al. Genes Cells, 2007 May. PMID 17535251
    4. lon-1 regulates Caenorhabditis elegans body size downstream of the dbl-1 TGF beta signaling pathway. Maduzia LL, et al. Dev Biol, 2002 Jun 15. PMID 12051826
    5. Intestinal intermediate filament polypeptides in C. elegans: Common and isotype-specific contributions to intestinal ultrastructure and function. Geisler F, et al. Sci Rep, 2020 Feb 21. PMID 32081918, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dauer larval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in determination of adult lifespan IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in organelle localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in parturition IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in parturition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell size IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of multicellular organism growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in post-embryonic development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Mitogen-activated protein kinase sma-5;Protein kinase domain-containing protein
    NP_001041297.1
    • Confirmed by transcript evidence
    NP_001366649.1
    • Confirmed by transcript evidence
    NP_001379447.1
    • Confirmed by transcript evidence
    NP_001391190.1
    • Confirmed by transcript evidence
    NP_001407511.1
    • Confirmed by transcript evidence
    NP_741908.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      11997524..12005004 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392855.1 → NP_001379447.1  Mitogen-activated protein kinase sma-5 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      cd07855
      Location:30 → 374
      STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5

    2. NM_171782.6 → NP_741908.1  Mitogen-activated protein kinase sma-5 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741908.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EBT1
      Conserved Domains (2) summary
      smart00220
      Location:82 → 388
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07855
      Location:79 → 423
      STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5

    3. NM_001420578.1 → NP_001407511.1  Protein kinase domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A8S4QDG2

    4. NM_001381114.3 → NP_001366649.1  Mitogen-activated protein kinase sma-5 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      cd07855
      Location:79 → 423
      STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5

    5. NM_001047832.3 → NP_001041297.1  Mitogen-activated protein kinase sma-5 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001041297.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EBE9, G5EBM8, G5EBT1, G5EDH5
      Conserved Domains (2) summary
      smart00220
      Location:105 → 411
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd07855
      Location:102 → 446
      STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5

    6. NM_001404211.1 → NP_001391190.1  Protein kinase domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A8S4QBG0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EBT1.1

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