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    sma-1 Spectrin beta chain [ Caenorhabditis elegans ]

    Gene ID: 179629, updated on 25-Apr-2024

    Summary

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    Gene symbol
    sma-1
    Gene description
    Spectrin beta chain
    Primary source
    WormBase:WBGene00004855
    Locus tag
    CELE_R31.1
    See related
    AllianceGenome:WB:WBGene00004855
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable actin binding activity; guanyl-nucleotide exchange factor activity; and phospholipid binding activity. Involved in several processes, including pharyngeal gland morphogenesis; pharynx development; and positive regulation of cell size. Located in apical plasma membrane; cytoplasm; and nucleus. Is expressed in several structures, including excretory cell; hermaphrodite gonad; intestine; neurons; and pharynx. Orthologous to human SPTBN5 (spectrin beta, non-erythrocytic 5). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: V
    Exon count:
    18
    Sequence:
    Chromosome: V; NC_003283.11 (11899449..11916623)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ANK_REP_REGION domain-containing protein;Ubiquitin-like domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. sma-1 encodes a betaH-spectrin homolog required for Caenorhabditis elegans morphogenesis. McKeown C, et al. Development, 1998 Jun. PMID 9570773
    2. SMA-1 spectrin has essential roles in epithelial cell sheet morphogenesis in C. elegans. Praitis V, et al. Dev Biol, 2005 Jul 1. PMID 15890334
    3. Spectrin regulates cell contractility through production and maintenance of actin bundles in the Caenorhabditis elegans spermatheca. Wirshing ACE, et al. Mol Biol Cell, 2018 Oct 1. PMID 30091661, Free PMC Article
    4. A neuronal MAP kinase constrains growth of a Caenorhabditis elegans sensory dendrite throughout the life of the organism. McLachlan IG, et al. PLoS Genet, 2018 Jun. PMID 29879119, Free PMC Article
    5. The role of the ELAV homologue EXC-7 in the development of the Caenorhabditis elegans excretory canals. Fujita M, et al. Dev Biol, 2003 Apr 15. PMID 12679103

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament capping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in body morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryonic body morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in epithelial cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nematode larval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nematode pharyngeal gland morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nematode pharynx development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell size IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of organ growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of locomotion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of tube size IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cell projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cortical actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Spectrin beta chain
    NP_001129903.1
    • Confirmed by transcript evidence
    NP_001256382.1
    • Confirmed by transcript evidence
    NP_001256383.1
    • Confirmed by transcript evidence
    NP_001360523.1
    • Confirmed by transcript evidence
    NP_001380250.1
    • Confirmed by transcript evidence
    NP_741632.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      11899449..11916623
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171544.7 → NP_741632.2  Spectrin beta chain [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741632.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFW3
      Conserved Domains (7) summary
      pfam05483
      Location:1967 → 2724
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      smart00150
      Location:1453 → 1553
      SPEC; Spectrin repeats
      smart00326
      Location:928 → 979
      SH3; Src homology 3 domains
      cd00014
      Location:276 → 379
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:1770 → 1980
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd10571
      Location:3780 → 3883
      PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:3780 → 3881
      PH; PH domain

    2. NM_001373124.2 → NP_001360523.1  Spectrin beta chain [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A486WUT8
      Conserved Domains (5) summary
      smart00150
      Location:1453 → 1553
      SPEC; Spectrin repeats
      smart00326
      Location:928 → 979
      SH3; Src homology 3 domains
      COG5069
      Location:155 → 642
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:1770 → 1980
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd10571
      Location:3780 → 3883
      PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain

    3. NM_001269454.3 → NP_001256383.1  Spectrin beta chain [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256383.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EBH3
      Conserved Domains (6) summary
      smart00150
      Location:1350 → 1450
      SPEC; Spectrin repeats
      smart00326
      Location:825 → 876
      SH3; Src homology 3 domains
      cd00014
      Location:173 → 276
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:1667 → 1877
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd10571
      Location:3677 → 3780
      PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:3677 → 3778
      PH; PH domain

    4. NM_001136431.4 → NP_001129903.1  Spectrin beta chain [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001129903.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EC35
      Conserved Domains (7) summary
      pfam05483
      Location:1864 → 2621
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      smart00150
      Location:1350 → 1450
      SPEC; Spectrin repeats
      smart00326
      Location:825 → 876
      SH3; Src homology 3 domains
      cd00014
      Location:173 → 276
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:1667 → 1877
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd10571
      Location:3677 → 3780
      PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:3677 → 3778
      PH; PH domain

    5. NM_001269453.3 → NP_001256382.1  Spectrin beta chain [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001256382.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EG97
      Conserved Domains (7) summary
      pfam05483
      Location:1781 → 2538
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      smart00150
      Location:1267 → 1367
      SPEC; Spectrin repeats
      smart00326
      Location:742 → 793
      SH3; Src homology 3 domains
      cd00014
      Location:90 → 193
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      cd00176
      Location:1584 → 1794
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd10571
      Location:3594 → 3697
      PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:3594 → 3695
      PH; PH domain

    6. NM_001392621.1 → NP_001380250.1  Spectrin beta chain [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A486WVF0
      Conserved Domains (6) summary
      smart00150
      Location:1267 → 1367
      SPEC; Spectrin repeats
      smart00326
      Location:742 → 793
      SH3; Src homology 3 domains
      COG5069
      Location:2 → 456
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:1584 → 1794
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd10571
      Location:3594 → 3697
      PH_beta_spectrin; Beta-spectrin pleckstrin homology (PH) domain
      cd21194
      Location:88 → 192
      CH_beta_spectrin_rpt2; second calponin homology (CH) domain found in the beta spectrin family
    Nucleotide Protein
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