osm-3 Osmotic avoidance abnormal protein 3 [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: osm-3
Gene description: Osmotic avoidance abnormal protein 3
Primary source: WormBase:WBGene00003884
Locus tag: CELE_M02B7.3
See related: AllianceGenome:WB:WBGene00003884
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables plus-end-directed microtubule motor activity. Involved in several processes, including cilium organization; dauer entry; and regulation of non-motile cilium assembly. Located in several cellular components, including ciliary basal body; neuronal cell body; and perinuclear region of cytoplasm. Part of kinesin complex. Is expressed in ciliated neurons. Orthologous to human KIF17 (kinesin family member 17). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: IV

Exon count:: 10

Sequence:: Chromosome: IV; NC_003282.8 (3796300..3800461, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The physiological cargo adaptor of kinesin-2 functions as an evolutionary conserved lockpick.
Title: The physiological cargo adaptor of kinesin-2 functions as an evolutionary conserved lockpick.
Structural snapshots of the kinesin-2 OSM-3 along its nucleotide cycle: implications for the ATP hydrolysis mechanism.
Title: Structural snapshots of the kinesin-2 OSM-3 along its nucleotide cycle: implications for the ATP hydrolysis mechanism.
OSM-3 mutations cause NPHP-4 dependent and independent phenotypes.
Title: A Screen for Modifiers of Cilia Phenotypes Reveals Novel MKS Alleles and Uncovers a Specific Genetic Interaction between osm-3 and nphp-4.
Data show that kinesin-II and OSM-3 facilitate ciliary import and long-range transport.
Title: Functional differentiation of cooperating kinesin-2 motors orchestrates cargo import and transport in C. elegans cilia.
Dauer pheromone and gpa-3 signaling modulate the coordination of intraflagellar transport of kinesin-II and OSM-3.
Title: Dauer pheromone and G-protein signaling modulate the coordination of intraflagellar transport kinesin motor proteins in C. elegans.
Wild-type worms are induced to display an L1 (first larval stage) surface epitope at later larval stages when grown on an extract of spent culture medium; this was abolished in chemotaxis-defective osm-3 mutants.
Title: Chemosensory control of surface antigen switching in the nematode Caenorhabditis elegans.
OSM-3 is an accessory intraflagellar transport (IFT) kinesin motor; subtle changes in its deployment or actions can contribute to differences in cilia morphology, cilia function, and sensory perception.
Title: Functional modulation of IFT kinesins extends the sensory repertoire of ciliated neurons in Caenorhabditis elegans.
In this study, using a single-molecule fluorescence assay, the investigators show that bacterially expressed OSM-3 in solution does not move processively and displays low microtubule-stimulated adenosine triphosphatase (ATPase) activity.
Title: Autoinhibition regulates the motility of the C. elegans intraflagellar transport motor OSM-3.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

M02B7.3 (e-PCR)
- UniSTS:311965

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule motor activity	IDA Inferred from Direct Assay more info	PubMed
enables microtubule motor activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables plus-end-directed microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables plus-end-directed microtubule motor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in anterograde dendritic transport of neurotransmitter receptor complex	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell projection organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in cilium assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dauer entry	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intraciliary anterograde transport	IDA Inferred from Direct Assay more info	PubMed
involved_in intraciliary anterograde transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intraciliary anterograde transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intraciliary transport	IDA Inferred from Direct Assay more info	PubMed
involved_in microtubule-based movement	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of non-motile cilium assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in non-motile cilium assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of dauer larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of non-motile cilium assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of non-motile cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of insulin receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in ciliary basal body	IDA Inferred from Direct Assay more info	PubMed
is_active_in cilium	IBA Inferred from Biological aspect of Ancestor more info
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite cytoplasm	IEA Inferred from Electronic Annotation more info
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of kinesin complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
is_active_in microtubule organizing center	IBA Inferred from Biological aspect of Ancestor more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in non-motile cilium	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Osmotic avoidance abnormal protein 3

NP_001367795.1

Confirmed by transcript evidence

NP_001367796.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

3796300..3800461 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001380164.2 → NP_001367795.1 Osmotic avoidance abnormal protein 3 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q9GV93

Conserved Domains (2) summary

TIGR02168
Location:314 → 531

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cl22853
Location:1 → 299

Motor_domain; Myosin and Kinesin motor domain
NM_001380163.1 → NP_001367796.1 Osmotic avoidance abnormal protein 3 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

P46873, Q8MPT7, Q8MPT8

UniProtKB/TrEMBL

Q9GV93

Conserved Domains (2) summary

TIGR02168
Location:342 → 559

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cl22853
Location:3 → 327

Motor_domain; Myosin and Kinesin motor domain