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    acdh-12 Very long-chain specific acyl-CoA dehydrogenase, mitochondrial [ Caenorhabditis elegans ]

    Gene ID: 174180, updated on 5-May-2024

    Summary

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    Gene symbol
    acdh-12
    Gene description
    Very long-chain specific acyl-CoA dehydrogenase, mitochondrial
    Primary source
    WormBase:WBGene00017125
    Locus tag
    CELE_E04F6.5
    See related
    AllianceGenome:WB:WBGene00017125
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable fatty-acyl-CoA binding activity and very-long-chain-acyl-CoA dehydrogenase activity. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in very long chain acyl-CoA dehydrogenase deficiency. Orthologous to human ACADVL (acyl-CoA dehydrogenase very long chain). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: II
    Exon count:
    8
    Sequence:
    Chromosome: II; NC_003280.10 (7192434..7194770, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Phosphodiesterase delta-like protein Neighboring gene G_PROTEIN_RECEP_F1_2 domain-containing protein Neighboring gene PLD phosphodiesterase domain-containing protein Neighboring gene ncRNA Neighboring gene MaoC-like domain-containing protein Neighboring gene Secreted protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Purification, crystallization and preliminary crystallographic analysis of very-long-chain acyl-CoA dehydrogenase from Caenorhabditis elegans. Li Z, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2010 Apr 1. PMID 20383014, Free PMC Article
    2. Identification of a novel mitochondrial complex I assembly factor ACDH-12 in Caenorhabditis elegans. Chuaijit S, et al. Mitochondrion, 2019 May. PMID 29540318
    3. A Caenorhabditis elegans nutrient response system partially dependent on nuclear receptor NHR-49. Van Gilst MR, et al. Proc Natl Acad Sci U S A, 2005 Sep 20. PMID 16157872, Free PMC Article
    4. Identification and characterization of novel nicotinic receptor-associated proteins in Caenorhabditis elegans. Gottschalk A, et al. EMBO J, 2005 Jul 20. PMID 15990870, Free PMC Article
    5. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The authors demonstrate for the first time that a deficiency of ACDH-12 affects the formation and function of complex I. They suggest that in Caenorhabditis elegans, ACDH-12 is required for the assembly of the respiratory complex I, but may not be crucial to fatty acid oxidation.
      Title: Identification of a novel mitochondrial complex I assembly factor ACDH-12 in Caenorhabditis elegans.
    2. Purified very-long-chain acyl-CoA dehydrogenase (12 mg ml(-1)) was successfully crystallized by the hanging-drop vapour-diffusion method under conditions containing 100 mM Tris-HCl pH 8.0, 150 mM sodium chloride, 200 mM magnesium formate and 13% PEG 3350.
      Title: Purification, crystallization and preliminary crystallographic analysis of very-long-chain acyl-CoA dehydrogenase from Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables fatty-acyl-CoA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-CH group of donors IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables very-long-chain fatty acyl-CoA dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Very long-chain specific acyl-CoA dehydrogenase, mitochondrial
    NP_001022062.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      7192434..7194770 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001026891.7 → NP_001022062.1  Very long-chain specific acyl-CoA dehydrogenase, mitochondrial [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022062.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19057
      Conserved Domains (2) summary
      cd01161
      Location:41 → 449
      VLCAD; Very long chain acyl-CoA dehydrogenase
      COG1960
      Location:61 → 441
      CaiA; Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and metabolism]

    RNA

    1. NR_151558.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version

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