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    SPDYE17 speedy/RINGO cell cycle regulator family member E17 [ Homo sapiens (human) ]

    Gene ID: 102723849, updated on 23-Nov-2023

    Summary

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    Official Symbol
    SPDYE17provided by HGNC
    Official Full Name
    speedy/RINGO cell cycle regulator family member E17provided by HGNC
    Primary source
    HGNC:HGNC:51513
    See related
    Ensembl:ENSG00000186645 AllianceGenome:HGNC:51513
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Broad expression in testis (RPKM 9.5), skin (RPKM 2.8) and 23 other tissues See more
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    Genomic context

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    Location:
    7q11.23
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (77022306..77032361, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (76566553..76576615)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (76651623..76661678, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene DTX2P1-UPK3BP1-PMS2P11 readthrough, transcribed pseudogene Neighboring gene DTX2 pseudogene 1 Neighboring gene farnesyl diphosphate synthase pseudogene 7 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:76612883-76613456 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26202 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:76628288-76629118 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:76629119-76629947 Neighboring gene Sharpr-MPRA regulatory region 3059 Neighboring gene uroplakin 3B pseudogene 1 Neighboring gene PMS1 homolog 2, mismatch repair system component pseudogene 11 Neighboring gene PMS1 homolog 2, mismatch repair system component pseudogene 9 Neighboring gene speedy/RINGO cell cycle regulator family member E18 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:76693975-76694649 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Established and novel Cdk/cyclin complexes regulating the cell cycle and development. Gopinathan L, et al. Results Probl Cell Differ, 2011. PMID 21630153
    2. CDK activation by non-cyclin proteins. Nebreda AR. Curr Opin Cell Biol, 2006 Apr. PMID 16488127
    3. Evolution of the Cdk-activator Speedy/RINGO in vertebrates. Chauhan S, et al. Cell Mol Life Sci, 2012 Nov. PMID 22763696
    4. Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins. Cheng A, et al. Cell Cycle, 2005 Jan. PMID 15611625
    5. Characterization of a new family of cyclin-dependent kinase activators. Dinarina A, et al. Biochem J, 2005 Mar 1. PMID 15574121, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative speedy protein E17

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001351351.3 → NP_001338280.1  putative speedy protein E17

      Status: VALIDATED

      Source sequence(s)
      AC007000, AC114737
      Consensus CDS
      CCDS94130.1
      UniProtKB/Swiss-Prot
      A0A494C191, P0DTA3, P0DUD1, P0DUD2, P0DUX0
      Related
      ENSP00000501236.1, ENST00000671986.3
      Conserved Domains (1) summary
      pfam11357
      Location:107 → 261
      Spy1; Cell cycle regulatory protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      77022306..77032361 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047419719.1 → XP_047275675.1  putative speedy protein E17 isoform X1

      UniProtKB/Swiss-Prot
      A0A494C191, P0DTA3, P0DUD1, P0DUD2, P0DUX0

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      76566553..76576615
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0DUD2.1 GenPept UniProtKB/Swiss-Prot:P0DUD2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases