| The innovative checkpoint inhibitors of lung adenocarcinoma, cg09897064 methylation and ZBP1 expression reduction, have implications for macrophage polarization and tumor growth in lung cancer. | The innovative checkpoint inhibitors of lung adenocarcinoma, cg09897064 methylation and ZBP1 expression reduction, have implications for macrophage polarization and tumor growth in lung cancer.
Wang A, Zheng WS, Luo Z, Bai L, Zhang S., Free PMC Article | 03/21/2024 |
| Bile acid-induced IRF3 phosphorylation mediates cell death, inflammatory responses, and fibrosis in cholestasis-induced liver and kidney injury via regulation of ZBP1. | Bile acid-induced IRF3 phosphorylation mediates cell death, inflammatory responses, and fibrosis in cholestasis-induced liver and kidney injury via regulation of ZBP1.
Zhuang Y, Ortega-Ribera M, Thevkar Nagesh P, Joshi R, Huang H, Wang Y, Zivny A, Mehta J, Parikh SM, Szabo G., | 03/20/2024 |
| Heartbreakers: innate sensors ZBP1 and cGAS linked to cardiotoxicity. | Heartbreakers: innate sensors ZBP1 and cGAS linked to cardiotoxicity.
Chen W, Kanneganti TD., | 12/22/2023 |
| PANoptosome signaling and therapeutic implications in infection: central role for ZBP1 to activate the inflammasome and PANoptosis. | PANoptosome signaling and therapeutic implications in infection: central role for ZBP1 to activate the inflammasome and PANoptosis.
Karki R, Kanneganti TD., | 08/10/2023 |
| Z-form nucleic acid-binding protein 1 (ZBP1) as a sensor of viral and cellular Z-RNAs: walking the razor's edge. | Z-form nucleic acid-binding protein 1 (ZBP1) as a sensor of viral and cellular Z-RNAs: walking the razor's edge.
DeAntoneo C, Herbert A, Balachandran S., | 08/9/2023 |
| ADAR1 and ZBP1 in innate immunity, cell death, and disease. | ADAR1 and ZBP1 in innate immunity, cell death, and disease.
Karki R, Kanneganti TD., Free PMC Article | 03/2/2023 |
| Telomere-to-mitochondria signalling by ZBP1 mediates replicative crisis. | Telomere-to-mitochondria signalling by ZBP1 mediates replicative crisis.
Nassour J, Aguiar LG, Correia A, Schmidt TT, Mainz L, Przetocka S, Haggblom C, Tadepalle N, Williams A, Shokhirev MN, Akincilar SC, Tergaonkar V, Shadel GS, Karlseder J., Free PMC Article | 02/25/2023 |
| ZBP1-Mediated Necroptosis: Mechanisms and Therapeutic Implications. | ZBP1-Mediated Necroptosis: Mechanisms and Therapeutic Implications.
Chen XY, Dai YH, Wan XX, Hu XM, Zhao WJ, Ban XX, Wan H, Huang K, Zhang Q, Xiong K., Free PMC Article | 02/11/2023 |
| Fusobacterium nucleatum triggers proinflammatory cell death via Z-DNA binding protein 1 in apical periodontitis. | Fusobacterium nucleatum triggers proinflammatory cell death via Z-DNA binding protein 1 in apical periodontitis.
Liu H, Liu Y, Fan W, Fan B., Free PMC Article | 12/31/2022 |
| Human ZBP1 induces cell death-independent inflammatory signaling via RIPK3 and RIPK1. | Human ZBP1 induces cell death-independent inflammatory signaling via RIPK3 and RIPK1.
Peng R, Wang CK, Wang-Kan X, Idorn M, Kjaer M, Zhou FY, Fiil BK, Timmermann F, Orozco SL, McCarthy J, Leung CS, Lu X, Bagola K, Rehwinkel J, Oberst A, Maelfait J, Paludan SR, Gyrd-Hansen M., Free PMC Article | 12/24/2022 |
| Z-DNA/RNA Binding Protein 1 Senses Mitochondrial DNA to Induce Receptor-Interacting Protein Kinase-3/Mixed Lineage Kinase Domain-Like-Driven Necroptosis in Developmental Sevoflurane Neurotoxicity. | Z-DNA/RNA Binding Protein 1 Senses Mitochondrial DNA to Induce Receptor-Interacting Protein Kinase-3/Mixed Lineage Kinase Domain-Like-Driven Necroptosis in Developmental Sevoflurane Neurotoxicity.
Wang WY, Yi WQ, Liu YS, Hu QY, Qian SJ, Liu JT, Mao H, Cai F, Yang HL. | 12/24/2022 |
| ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation. | ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation.
de Reuver R, Verdonck S, Dierick E, Nemegeer J, Hessmann E, Ahmad S, Jans M, Blancke G, Van Nieuwerburgh F, Botzki A, Vereecke L, van Loo G, Declercq W, Hur S, Vandenabeele P, Maelfait J. | 08/6/2022 |
| ADAR1 masks the cancer immunotherapeutic promise of ZBP1-driven necroptosis. | ADAR1 masks the cancer immunotherapeutic promise of ZBP1-driven necroptosis.
Zhang T, Yin C, Fedorov A, Qiao L, Bao H, Beknazarov N, Wang S, Gautam A, Williams RM, Crawford JC, Peri S, Studitsky V, Beg AA, Thomas PG, Walkley C, Xu Y, Poptsova M, Herbert A, Balachandran S., Free PMC Article | 07/2/2022 |
| Oxidative stress induces Z-DNA-binding protein 1-dependent activation of microglia via mtDNA released from retinal pigment epithelial cells. | Oxidative stress induces Z-DNA-binding protein 1-dependent activation of microglia via mtDNA released from retinal pigment epithelial cells.
Saada J, McAuley RJ, Marcatti M, Tang TZ, Motamedi M, Szczesny B., Free PMC Article | 05/21/2022 |
| Z-DNA binding protein 1 promotes heatstroke-induced cell death. | Z-DNA binding protein 1 promotes heatstroke-induced cell death.
Yuan F, Cai J, Wu J, Tang Y, Zhao K, Liang F, Li F, Yang X, He Z, Billiar TR, Wang H, Su L, Lu B. | 05/14/2022 |
| TRIM34 modulates influenza virus-activated programmed cell death by targeting Z-DNA-binding protein 1 for K63-linked polyubiquitination. | TRIM34 modulates influenza virus-activated programmed cell death by targeting Z-DNA-binding protein 1 for K63-linked polyubiquitination.
Wang X, Xiong J, Zhou D, Zhang S, Wang L, Tian Q, Li C, Liu J, Wu Y, Li J, Wang J., Free PMC Article | 04/30/2022 |
| The innate sensor ZBP1-IRF3 axis regulates cell proliferation in multiple myeloma. | The innate sensor ZBP1-IRF3 axis regulates cell proliferation in multiple myeloma.
Ponnusamy K, Tzioni MM, Begum M, Robinson ME, Caputo VS, Katsarou A, Trasanidis N, Xiao X, Kostopoulos IV, Iskander D, Roberts I, Trivedi P, Auner HW, Naresh K, Chaidos A, Karadimitris A., Free PMC Article | 04/16/2022 |
| Viral Z-RNA triggers ZBP1-dependent cell death. | Viral Z-RNA triggers ZBP1-dependent cell death.
Balachandran S, Mocarski ES., Free PMC Article | 02/5/2022 |
| Vaccinia virus E3 prevents sensing of Z-RNA to block ZBP1-dependent necroptosis. | Vaccinia virus E3 prevents sensing of Z-RNA to block ZBP1-dependent necroptosis.
Koehler H, Cotsmire S, Zhang T, Balachandran S, Upton JW, Langland J, Kalman D, Jacobs BL, Mocarski ES., Free PMC Article | 12/11/2021 |
| AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence. | AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence.
Lee S, Karki R, Wang Y, Nguyen LN, Kalathur RC, Kanneganti TD., Free PMC Article | 09/25/2021 |
| Enrichment of Zalpha domains at cytoplasmic stress granules is due to their innate ability to bind to nucleic acids. | Enrichment of Zα domains at cytoplasmic stress granules is due to their innate ability to bind to nucleic acids.
Gabriel L, Srinivasan B, Kuś K, Mata JF, João Amorim M, Jansen LET, Athanasiadis A. | 09/4/2021 |
| ZBP1 not RIPK1 mediates tumor necroptosis in breast cancer. | ZBP1 not RIPK1 mediates tumor necroptosis in breast cancer.
Baik JY, Liu Z, Jiao D, Kwon HJ, Yan J, Kadigamuwa C, Choe M, Lake R, Kruhlak M, Tandon M, Cai Z, Choksi S, Liu ZG., Free PMC Article | 06/5/2021 |
| ZBP1 promotes fungi-induced inflammasome activation and pyroptosis, apoptosis, and necroptosis (PANoptosis). | ZBP1 promotes fungi-induced inflammasome activation and pyroptosis, apoptosis, and necroptosis (PANoptosis).
Banoth B, Tuladhar S, Karki R, Sharma BR, Briard B, Kesavardhana S, Burton A, Kanneganti TD., Free PMC Article | 03/28/2021 |
| this paper reviews the history and emergence of ZBP1 as a pathogen sensor and a central regulator of cell death and inflammatory responses | ZBP1: Innate Sensor Regulating Cell Death and Inflammation.
Kuriakose T, Kanneganti TD., Free PMC Article | 11/10/2018 |
| PUMA promotes the cytosolic release of mitochondrial DNA and activation of the DNA sensors DAI/Zbp1 and STING, leading to enhanced RIP3 and MLKL phosphorylation in a positive feedback loop. | PUMA amplifies necroptosis signaling by activating cytosolic DNA sensors.
Chen D, Tong J, Yang L, Wei L, Stolz DB, Yu J, Zhang J, Zhang L., Free PMC Article | 10/13/2018 |