| No evidence that ACE2 or TMPRSS2 drive population disparity in COVID risks. | No evidence that ACE2 or TMPRSS2 drive population disparity in COVID risks.
Pearson NM, Novembre J., Free PMC Article | 08/30/2024 |
| Novel proteolytic activation of Ebolavirus glycoprotein GP by TMPRSS2 and cathepsin L at an uncharted position can compensate for furin cleavage. | Novel proteolytic activation of Ebolavirus glycoprotein GP by TMPRSS2 and cathepsin L at an uncharted position can compensate for furin cleavage.
Bestle D, Bittel L, Werner AD, Kämper L, Dolnik O, Krähling V, Steinmetzer T, Böttcher-Friebertshäuser E., Free PMC Article | 08/29/2024 |
| TMPRSS2 and glycan receptors synergistically facilitate coronavirus entry. | TMPRSS2 and glycan receptors synergistically facilitate coronavirus entry.
Wang H, Liu X, Zhang X, Zhao Z, Lu Y, Pu D, Zhang Z, Chen J, Wang Y, Li M, Dong X, Duan Y, He Y, Mao Q, Guo H, Sun H, Zhou Y, Yang Q, Gao Y, Yang X, Cao H, Guddat L, Sun L, Rao Z, Yang H. | 08/13/2024 |
| Association of specific ACE2 and TMPRSS2 variants with circulatory cytokines of COVID-19 Emirati patients. | Association of specific ACE2 and TMPRSS2 variants with circulatory cytokines of COVID-19 Emirati patients.
Elemam NM, Bouzid A, Alsafar H, Ahmed SB, Hafezi S, Venkatachalam T, Eldohaji L, Al Hamidi T, Gerges PH, Halabi N, Hadj-Kacem H, Talaat IM, Taneera J, Sulaiman N, Maghazachi AA, Hamid Q, Hamoudi R, Saber-Ayad M., Free PMC Article | 07/10/2024 |
| Association of ACE2 and TMPRSS2 genes variants with disease severity and most important biomarkers in COVID-19 patients in Bosnia and Herzegovina. | Association of ACE2 and TMPRSS2 genes variants with disease severity and most important biomarkers in COVID-19 patients in Bosnia and Herzegovina.
Meseldžić N, Prnjavorac B, Dujić T, Malenica M, Glamočlija U, Prnjavorac L, Bedak O, Imamović Kadrić S, Marjanović D, Bego T., Free PMC Article | 06/27/2024 |
| ACE2 acts as a novel regulator of TMPRSS2-catalyzed proteolytic activation of influenza A virus in airway cells. | ACE2 acts as a novel regulator of TMPRSS2-catalyzed proteolytic activation of influenza A virus in airway cells.
Heindl MR, Rupp A-L, Schwerdtner M, Bestle D, Harbig A, De Rocher A, Schmacke LC, Staker B, Steinmetzer T, Stein DA, Moulton HM, Böttcher-Friebertshäuser E., Free PMC Article | 05/3/2024 |
| Expression of the SARS-CoV-2 Receptor ACE2 and Protease TMPRSS2 in Ocular Hypertension Eyes of Nonhuman Primate and Human. | Expression of the SARS-CoV-2 Receptor ACE2 and Protease TMPRSS2 in Ocular Hypertension Eyes of Nonhuman Primate and Human.
Sun D, Zhan Z, Wang B, Liu T, Yu M, Lan Y, Li J. | 02/27/2024 |
| Host genetics and the profile of COVID-19 in indigenous people from the Brazilian Amazon: A pilot study with variants of the ACE1, ACE2 and TMPRSS2 genes. | Host genetics and the profile of COVID-19 in indigenous people from the Brazilian Amazon: A pilot study with variants of the ACE1, ACE2 and TMPRSS2 genes.
Putira Sacuena ER, Lima CNC, Abreu IN, da Silva LMC, Belleza LKG, Lemes RB, de Araújo GS, da Silva HP, Vallinoto ACR, Guerreiro JF. | 02/27/2024 |
| Increased ACE2 and TMPRSS2 expression in ulcerative colitis. | Increased ACE2 and TMPRSS2 expression in ulcerative colitis.
Hamamoto Y, Kawamura M, Uchida H, Hiramatsu K, Katori C, Asai H, Egawa S, Yoshida K. | 02/15/2024 |
| Evaluation of relationship between TMPRSS2 p.(Val197Met) variant and COVID-19 susceptibility and severity. | Evaluation of relationship between TMPRSS2 p.(Val197Met) variant and COVID-19 susceptibility and severity.
Bashar NAS, Gohar NMA, Tantawy AA, Kamel MHM., Free PMC Article | 02/12/2024 |
| The relationship between the clinical course of SARS-CoV-2 infections and ACE2 and TMPRSS2 expression and polymorphisms. | The relationship between the clinical course of SARS-CoV-2 infections and ACE2 and TMPRSS2 expression and polymorphisms.
Tug E, Fidan I, Bozdayi G, Yildirim F, Tunccan OG, Lale Z, Akdogan D. | 02/6/2024 |
| Genetic association of ACE2 and TMPRSS2 polymorphisms with COVID-19 severity; a single centre study from Egypt. | Genetic association of ACE2 and TMPRSS2 polymorphisms with COVID-19 severity; a single centre study from Egypt.
Elnagdy MH, Magdy A, Eldars W, Elgamal M, El-Nagdy AH, Salem O, Elmowafy MM, Elborsh OA, Elshafey AW, Kesba MM, Abdulgalil AE, Sobh A., Free PMC Article | 02/5/2024 |
| Genetic polymorphisms of ACE1, ACE2, IFTM3, TMPRSS2 and TNFalpha genes associated with susceptibility and severity of SARS-CoV-2 infection: a systematic review and meta-analysis. | Genetic polymorphisms of ACE1, ACE2, IFTM3, TMPRSS2 and TNFα genes associated with susceptibility and severity of SARS-CoV-2 infection: a systematic review and meta-analysis.
Pecoraro V, Cuccorese M, Trenti T., Free PMC Article | 12/1/2023 |
| Conformational response to ligand binding of TMPRSS2, a protease involved in SARS-CoV-2 infection: Insights through computational modeling. | Conformational response to ligand binding of TMPRSS2, a protease involved in SARS-CoV-2 infection: Insights through computational modeling.
Frumenzio G, Chandramouli B, Besker N, Grottesi A, Talarico C, Frigerio F, Emerson A, Musiani F. | 10/20/2023 |
| SARS-CoV-2 Omicron entry is type II transmembrane serine protease-mediated in human airway and intestinal organoid models. | SARS-CoV-2 Omicron entry is type II transmembrane serine protease-mediated in human airway and intestinal organoid models.
Mykytyn AZ, Breugem TI, Geurts MH, Beumer J, Schipper D, van Acker R, van den Doel PB, van Royen ME, Zhang J, Clevers H, Haagmans BL, Lamers MM., Free PMC Article | 09/6/2023 |
| Human TMPRSS2 non-catalytic ectodomain and SARS-CoV-2 S2' subunit interaction mediated SARS-CoV-2 endocytosis: a model proposal with virtual screening for potential drug molecules to inhibit this interaction. | Human TMPRSS2 non-catalytic ectodomain and SARS-CoV-2 S2' subunit interaction mediated SARS-CoV-2 endocytosis: a model proposal with virtual screening for potential drug molecules to inhibit this interaction.
Konduru GV, Nagarajaram HA. | 07/19/2023 |
| Spike substitution T813S increases Sarbecovirus fusogenicity by enhancing the usage of TMPRSS2. | Spike substitution T813S increases Sarbecovirus fusogenicity by enhancing the usage of TMPRSS2.
Ma Y, Li P, Hu Y, Qiu T, Wang L, Lu H, Lv K, Xu M, Zhuang J, Liu X, He S, He B, Liu S, Liu L, Wang Y, Yue X, Zhai Y, Luo W, Mai H, Kuang Y, Chen S, Ye F, Zhou N, Zhao W, Chen J, Chen S, Xiong X, Shi M, Pan JA, Chen YQ., Free PMC Article | 06/3/2023 |
| Expression of TMPRSS2 is up-regulated by bacterial flagellin, LPS, and Pam3Cys in human airway cells. | Expression of TMPRSS2 is up-regulated by bacterial flagellin, LPS, and Pam3Cys in human airway cells.
Schwerdtner M, Skalik A, Limburg H, Bierwagen J, Jung AL, Dorna J, Kaufmann A, Bauer S, Schmeck B, Böttcher-Friebertshäuser E., Free PMC Article | 05/30/2023 |
| SARS-CoV-2 Infection of Human Neurons Is TMPRSS2 Independent, Requires Endosomal Cell Entry, and Can Be Blocked by Inhibitors of Host Phosphoinositol-5 Kinase. | SARS-CoV-2 Infection of Human Neurons Is TMPRSS2 Independent, Requires Endosomal Cell Entry, and Can Be Blocked by Inhibitors of Host Phosphoinositol-5 Kinase.
Kettunen P, Lesnikova A, Räsänen N, Ojha R, Palmunen L, Laakso M, Lehtonen Š, Kuusisto J, Pietiläinen O, Saber SH, Joensuu M, Vapalahti OP, Koistinaho J, Rolova T, Balistreri G., Free PMC Article | 05/19/2023 |
| Association between tissue stress reaction and ACE2/TMPRSS2 expression in endometria of reproductive aged women before and during Covid-19 pandemic. | Association between tissue stress reaction and ACE2/TMPRSS2 expression in endometria of reproductive aged women before and during Covid-19 pandemic.
Ogawa K, Khan KN, Koshiba A, Fujishita A, Horiguchi G, Teramukai S, Itoh K, Guo SW, Mori T., Free PMC Article | 05/11/2023 |
| Impact of ACE2 and TMPRSS2 Expression in Patients With Preeclampsia. | Impact of ACE2 and TMPRSS2 Expression in Patients With Preeclampsia.
Park JE, Song DH, Kim YM, Jo HC, Baek JC, Kim H, Yang J, An HJ., Free PMC Article | 03/14/2023 |
| TMPRSS2 polymorphism (rs12329760) and the severity of the COVID-19 in Iranian population. | TMPRSS2 polymorphism (rs12329760) and the severity of the COVID-19 in Iranian population.
Yaghoobi A, Lord JS, Rezaiezadeh JS, Yekaninejad MS, Amini M, Izadi P., Free PMC Article | 02/22/2023 |
| Polymorphism of tmprss2 (rs12329760) but not ace2 (rs4240157), tmprss11a (rs353163) and cd147 (rs8259) is associated with the severity of COVID-19 in the Ukrainian population. | Polymorphism of tmprss2 (rs12329760) but not ace2 (rs4240157), tmprss11a (rs353163) and cd147 (rs8259) is associated with the severity of COVID-19 in the Ukrainian population.
Kaidashev I, Izmailova O, Shlykova O, Kabaliei A, Vatsenko A, Ivashchenko D, Dudchenko M, Volianskyi A, Zelinskyy G, Koval T, Dittmer U., Free PMC Article | 02/16/2023 |
| Polymorphisms in ACE1, TMPRSS2, IFIH1, IFNAR2, and TYK2 Genes Are Associated with Worse Clinical Outcomes in COVID-19. | Polymorphisms in ACE1, TMPRSS2, IFIH1, IFNAR2, and TYK2 Genes Are Associated with Worse Clinical Outcomes in COVID-19.
Dieter C, de Almeida Brondani L, Lemos NE, Schaeffer AF, Zanotto C, Ramos DT, Girardi E, Pellenz FM, Camargo JL, Moresco KS, da Silva LL, Aubin MR, de Oliveira MS, Rech TH, Canani LH, Gerchman F, Leitão CB, Crispim D., Free PMC Article | 02/11/2023 |
| Native and activated antithrombin inhibits TMPRSS2 activity and SARS-CoV-2 infection. | Native and activated antithrombin inhibits TMPRSS2 activity and SARS-CoV-2 infection.
Wettstein L, Immenschuh P, Weil T, Conzelmann C, Almeida-Hernández Y, Hoffmann M, Kempf A, Nehlmeier I, Lotke R, Petersen M, Stenger S, Kirchhoff F, Sauter D, Pöhlmann S, Sanchez-Garcia E, Münch J., Free PMC Article | 01/28/2023 |