| DERL2 (derlin 2) stabilizes BAG6 (BAG cochaperone 6) in chemotherapy resistance of cholangiocarcinoma. | DERL2 (derlin 2) stabilizes BAG6 (BAG cochaperone 6) in chemotherapy resistance of cholangiocarcinoma.
Liu L, Wu J, Yan Y, Cheng S, Yu S, Wang Y., Free PMC Article | 02/13/2024 |
| Endoplasmic Reticulum-Associated Degradation Controls Virus Protein Homeostasis, Which Is Required for Flavivirus Propagation. | Endoplasmic Reticulum-Associated Degradation Controls Virus Protein Homeostasis, Which Is Required for Flavivirus Propagation.
Tabata K, Arakawa M, Ishida K, Kobayashi M, Nara A, Sugimoto T, Okada T, Mori K, Morita E., Free PMC Article | 08/28/2021 |
| Derlin-2 is part of a protein quality control mechanism that can rescue glomerular injury attributable to impaired protein folding pathways in the endoplasmic reticulum. | Podocytes exhibit a specialized protein quality control employing derlin-2 in kidney disease.
Ren G, Tardi NJ, Matsuda F, Koh KH, Ruiz P, Wei C, Altintas MM, Ploegh H, Reiser J. | 05/4/2019 |
| specific silencing of Derlin-2, p97 and HRD1 by shRNAs increases steady state levels of proinsulin. these ERAD constituents are critically involved in proinsulin degradation and may therefore also play a role in subsequent antigen generation. | Proteasomal Degradation of Proinsulin Requires Derlin-2, HRD1 and p97.
Hoelen H, Zaldumbide A, van Leeuwen WF, Torfs EC, Engelse MA, Hassan C, Lebbink RJ, de Koning EJ, Resssing ME, de Ru AH, van Veelen PA, Hoeben RC, Roep BO, Wiertz EJ., Free PMC Article | 04/2/2016 |
| derlin2 functions with HRD1 in ERAD of certain substrates independent of their glycosylation status. | Derlin2 protein facilitates HRD1-mediated retro-translocation of sonic hedgehog at the endoplasmic reticulum.
Huang CH, Hsiao HT, Chu YR, Ye Y, Chen X., Free PMC Article | 12/14/2013 |
| Required for Polyoma virus infection. | Murine polyomavirus requires the endoplasmic reticulum protein Derlin-2 to initiate infection.
Lilley BN, Gilbert JM, Ploegh HL, Benjamin TL., Free PMC Article | 01/21/2010 |
| Findings indicate that Derlin-2 provides the missing link between EDEM and p97 in the process of degrading misfolded glycoproteins. | Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation.
Oda Y, Okada T, Yoshida H, Kaufman RJ, Nagata K, Mori K., Free PMC Article | 01/21/2010 |
| Derlin-2 forms a robust multiprotein complex with the p97 AAA ATPase as well as the mammalian orthologs of the yeast Hrd1p/Hrd3p ubiquitin-ligase complex, and participates in the degradation of proteins from the ER. | Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane.
Lilley BN, Ploegh HL., Free PMC Article | 01/21/2010 |