| Let-7b-5p is involved in the response of endoplasmic reticulum stress in acute pulmonary embolism through upregulating the expression of stress-associated endoplasmic reticulum protein 1. | Let-7b-5p is involved in the response of endoplasmic reticulum stress in acute pulmonary embolism through upregulating the expression of stress-associated endoplasmic reticulum protein 1.
Liu TW, Liu F, Kang J. | 11/27/2021 |
| Sec61beta may stabilize protein translocation by linking translocon complex to microtubule and provide insight into the physiological function of ER-microtubule interaction | Sec61β facilitates the maintenance of endoplasmic reticulum homeostasis by associating microtubules.
Zhu Y, Zhang G, Lin S, Shi J, Zhang H, Hu J., Free PMC Article | 06/8/2019 |
| used whole exome sequencing in a discovery cohort of 102 unrelated patients who were excluded for mutations in the 2 most common polycystic liver disease genes, PRKCSH and SEC63, to identify heterozygous loss-of-function mutations in 3 additional genes, ALG8, GANAB, and SEC61B. Similarly to PRKCSH and SEC63, these genes encode proteins that are integral to the protein biogenesis pathway in the endoplasmic reticulum. | Isolated polycystic liver disease genes define effectors of polycystin-1 function.
Besse W, Dong K, Choi J, Punia S, Fedeles SV, Choi M, Gallagher AR, Huang EB, Gulati A, Knight J, Mane S, Tahvanainen E, Tahvanainen P, Sanna-Cherchi S, Lifton RP, Watnick T, Pei YP, Torres VE, Somlo S., Free PMC Article | 09/16/2017 |
| These data confirm that the exocyst is preferentially involved in basolateral protein translation and translocation, and may well act through the phosphorylation of Sec61beta. | Exocyst Sec10 is involved in basolateral protein translation and translocation in the endoplasmic reticulum.
Choi SY, Fogelgren B, Zuo X, Huang L, McKenna S, Lingappa VR, Lipschutz JH., Free PMC Article | 06/20/2015 |
| Sec61beta overexpression increased tight junction modulation rates, in conjunction with enhanced delivery of claudin-4 from and to plasma membranes. | Sec61β regulates barrier functions of tight junction through expression of claudin-4 in Madin-Darby canine kidney cells.
Washiyama M, Koizumi N, Fujii M, Watanabe Y. | 01/24/2015 |
| Sec61beta-KD cells also exhibited altered ATP7A cellular distribution. | Sec61β controls sensitivity to platinum-containing chemotherapeutic agents through modulation of the copper-transporting ATPase ATP7A.
Abada PB, Larson CA, Manorek G, Adams P, Howell SB., Free PMC Article | 01/26/2013 |
| SEC61beta and its autoantibody as biomarkers for colorectal cancer | Identification of SEC61β and its autoantibody as biomarkers for colorectal cancer.
Fan CW, Chan CC, Chen KT, Twu J, Huang YS, Han CL, Chen YJ, Yu JS, Chang YS, Kuo YB, Chan EC. | 08/11/2012 |
| Sec61beta function provides an alternative pathway for nuclear transport that can be utilized by membrane-embedded proteins such as full-length EGFR. | The translocon Sec61beta localized in the inner nuclear membrane transports membrane-embedded EGF receptor to the nucleus.
Wang YN, Yamaguchi H, Huo L, Du Y, Lee HJ, Lee HH, Wang H, Hsu JM, Hung MC., Free PMC Article | 01/1/2011 |
| This indicates that EGF receptors are trafficked from the endoplasmic reticulum to the nucleus by a novel pathway that involves the Sec61 translocon. | Role of the Sec61 translocon in EGF receptor trafficking to the nucleus and gene expression.
Liao HJ, Carpenter G., Free PMC Article | 01/21/2010 |